Selenium is a toxicant or antitoxicant

• Autorzy: Bejanidze Irina , Jakeli Eteri , Davitadze Nazi , Nakashidze Nunu , Didmanidze Nato

Identyfikatory

DOI

10.12912/27197050/199459

• Języki publikacji: EN

Abstrakty

EN

The article deals with the issues of selenium content in plants, soil and human body, toxic and antitoxic properties of selenium. The studies were carried out on dried raw materials harvested in 2019 and 2021: stems, flowers and leaves of blueberries, chamomile, linden and oregano. The content of Se and other elements (Al, Fe, Mn, Ti. B, Pb, K, Mg, Ca, Zn, As and Cu) were determined both in plant material and in the soils of eastern Georgia (Abastumani) and western (Khulo), as well as in the hair of people living in this territory. The dependence of the selenium content on the type of plant and the time of its collection, the type of soil and distribution area was established, and an analysis was made of the Se coupling in these territories inhabitants hair. The influence of selenium on the accumulation of heavy metals in the objects of study was determined. It has been established that the largest amount of selenium is contained in the linden leaf, and the smallest – in the oregano leaf; selenium content increases in the order: leaf>flower>stem; the content of selenium in the soil of eastern Georgia (Abastumani) is 13 times higher than that in the soil of western Georgia (Khulo): Abastumani (0.051 μg/l)≫Khulo (0.039 μg/l). It has been established that selenium accumulates in the hair: the amount of selenium in the hair of a young girl (0.152 μg/l) is 70% higher than in the hair of a 60-year-old woman (0.055 μg/l). A high selenium to iodine ratio indicates gout and diabetes. It was found that an 18-year-old girl developed hypothyroidism due to an excess of selenium. It has been established that the amount of calcium and potassium is 2–5 times higher than the amount of magnesium. A relationship has been established between the content of selenium and lead: with an increase in the amount of lead, the amount of selenium sometimes decreases almost to a trace amount. In the objects of study, the amount of lead is 100-200 times higher than the amount of selenium. The largest amount of aluminum is found in the leaf, flowers of linden and oregano, the smallest – in the leaf of chamomile, iron in the flowers, and manganese in the leaves of the lind. The relationship between the content of selenium and arsenic, iron, phosphorus, zinc and manganese has been proven. An increase in phosphorus, zinc and manganese content reduces iron absorption and an increase in arsenic content causes a decrease in selenium content.

Słowa kluczowe

EN

heavy metals; selenism; elemental analysis; plants; toxicity

• Wydawca: Lubelski Oddział Polskiego Towarzystwo Inżynierii Ekologicznej ; Lublin University of Technology ; WNGB Wydawnictwo Naukowe
• Czasopismo: Ecological Engineering & Environmental Technology
• Rocznik: 2025
• Tom: Vol. 26, iss. 2
• Strony: 392--406
• Opis fizyczny: Bibliogr. 46 poz., rys.

Twórcy

autor

Bejanidze Irina

• Department of Chemistry, Batumi Shota Rustaveli State University, 35/32 Ninoshvili/Rustaveli Str., Batumi, GE 6010, Georgia

• https://orcid.org/0000-0002-8952-9861

autor

Jakeli Eteri

• Department of Internal Medicine, Batumi Shota Rustaveli State University, 35/32 Ninoshvili/Rustaveli Str., Batumi, GE 6010, Georgia

autor

Davitadze Nazi

• LTD Batumi Water, 19 Tabukashvili Str., Batumi, GE 6000, Georgia

autor

Nakashidze Nunu

• Department of Agroecology and Forestry, Batumi Shota Rustaveli State University, 35/32 Ninoshvili/Rustaveli Str., Batumi, GE 6010, Georgia

autor

Didmanidze Nato

• Department of Chemistry, Batumi Shota Rustaveli State University, 35/32 Ninoshvili/Rustaveli Str., Batumi, GE 6010, Georgia

Bibliografia

• 1. Batyrova, G.A., Umarova, G.A., Umarov, Ye.A., Kudabayeva, Kh.I., Tlegenova, Zh.Sh., Kononets, V.I., Aitmaganbet, P.Zh. 2021. Association of boron content in hair with morbidity rates in the boron geochemical province: cross-sectional study. Population Health and Habitat, 6(339), 41-47.
• 2. Bhattacharjee, A., Basu, A., Biswas, J., Sen, T., Bhattacharya, S. 2017. Chemoprotective and che- mosensitizing properties of selenium nanoparticle (Nano-Se) during adjuvant therapy with cyclophosphamide in tumor-bearing mice. Molecular and Cellular Biochemistry, 424(1-2), 13-33
• 4. Biryukova, E.V. 2017. Modern view on the role of selenium in the physiology and pathology of the thyroid gland. Effective Pharmacotherapy, 8, 34-41.
• 5. Blaurock-Busch, E., Amin, O.R., Dessoki, H.H., Rabah, T. 2012. Toxic metals and essential elements in hair and severity of symptoms among children with autism. Maedica, 7(1), 38-48.
• 6. Boulis, M., Boulis, M., Clauw, D. 2021. Magnesium and fibromyalgia; a literature review. J Prim Care Comm Health, 12:21501327211038433.
• 7. Cui, D., Liang, T., Sun, L., Meng, L., Yang, C., Wang, L., Liang, T., Li, Q. 2018. Green synthesis of selenium nanoparticles with extract of hawthorn fruit induced HepG2 cells apoptosis. Pharmaceutical Biology, 56(1), 528-534.
• 8. Duntas, L.H., Benvenga, S. 2015. Selenium: An element for life. Endocrine, 48(3), 756-775.
• 9. Deepa, K., Lingappa, Y. 2014. Spectrophotometric determination of selenium in industrial and environmental samples using vanillin-2-aminonicotinicacid (VANA). Der Pharma Chemica, 6(1), 52-60.
• 10. Favorito, J., Grossl, P., Davis, T., et al. 2021. Soilplant-animal relationships and geochemistry of selenium in the Western phosphate resource area (United States): a review. Chemosphere, 266:128959.
• 11. Gao, F., Yuan, Q., Gao, L., Cai, P., Zhu, H., Liu, R., Wang, Y., Wei, Y., Huang, G., Liang, J., Gao, X. 2014. Cytotoxicity and therapeutic effect of irinotecan combined with selenium nanoparticles. Biomaterials, 35(31), 8854-8866.
• 12. Guan, B., Yan, R., Li, R., Zhang, X. 2018. Selenium as a pleiotropic agent for medical discovery and drug delivery. International Journal of Nano-medicine, 13, 7473-7490.
• 13. Hanafi, K., Pedrero, Z., Ouerdane, L.,et .al. 2022. First time identification of selenoneine in seabirds and its potential role in mercury detoxification. Environ Sci Technol, 56(5), 3288-3298.
• 14. Hassan, M., Raza, M., Khan, I., et al. 2020. Selenium and salt interactions in black gram (Vigna mungoL): ion uptake, antioxidant defense system, and photochemistry efficiency. Plants (Basel), 9(4):467.
• 15. Huang, Y., He, L., Liu, W., Fan, C., Zheng, W., Wong, Y.S., Chen, T. 2013. Selective cellular uptake and induction of apoptosis of cancer-targeted selenium nanoparticles. Biomaterials, 34(29), 7106-7116.
• 16. Karnaukhova, I.V., Shiryaeva, O.Yu. 2018. Study of copper content and activity of copper-dependent superoxide dismutase in the human body. Scientific Review. Biological Sciences, 2, 10-14.
• 17. Khurana, A., Tekula, S., Saifi, M.A., Venkatesh, P., Godugu, C. 2019. Therapeutic applications of selenium nanoparticles. Biomedicine & Pharmacotherapy, 111, 802-812
• 18. Khan, S., Ullah, M.W., Siddique, R., Liu, Y., Ullah, I., Xue, M., Yang, G., Hou, H. 2019. Catechins-modified selenium-doped hydroxyapatite nanomaterials for improved osteosarcoma therapy through generation of reactive oxygen species.Frontiers In Oncology, 9, 499
• 19. Kieliszek, M., Błażejak, S. 2016. Current knowledge on the importance of selenium in food for living organisms: A review. Molecules (Basel, Switzerland), 21(5), 609.
• 20. Kumar, A., Prasad, K. 2021. Role of nano-selenium in health and environment. J Biotechnol10(325), 152-163.
• 21. Kumar, G.S., Kulkarni, A., Khurana, A., Kaur, J., Tikoo, K. 2014. Selenium nanoparticles involve HSP-70 and SIRT1 in preventing the progression of type 1 diabetic nephropathy. Chemico-Biological Interactions, 223, 125-133.
• 22. Li, M., Yun, H., Huang, J., et al. 2021. Hair selenium content in middle-aged and elderly Chinese population. Biol Trace Elem Res, 119(10), 3571-3578.
• 23. Li, M., Zhao, Z., Zhou, J., et al. 2018. Effects of afoliar spray of selenite or selenite at different growth stages on selenium distribution and quality of blueberries. J Sci Food Agric, 98(12), 4700-4706.
• 24. Liao, G., Ma, H., Li, Y., et al. 2021. Selenium nanoparticles inhibit tumor metastasis in prostatę cancer through upregulated miR-155-5p-related pathway. Biosci Biotechnol Biochem, 82(2), 287-296.
• 25. Loeschner, K., Hadrup, N., Hansen, M., Pereira, S.A., Gammelgaard, B., Møller, L.H., Mortensen, A., Lam, H.R., Larsen, E.H. 2014. Absorption, distribution, metabolism and excretion of selenium following oral administration of elemental selenium nanoparticles or selenite in rats. Metallomics, 6(2), 330-337.
• 26. Mary, T.A., Shanthi, K., Vimala, K., Soundarapandian, K. 2016. PEG functionalized selenium nanoparticles as a carrier of crocin to achieve anticancer synergism. RSC Advances, 6(27), 22936-22949.
• 27. Mehanna, E., Khalaf, S., Mesbah, N., et al. 2022. Antioxidant, anti-apoptotic, and mitochondrial regulatory effects of selenium nanoparticles against vancomycin induced nephrotoxicity in experimental rats. Life Sci, 1(288):120098.
• 28. Mojadadi, A., Au, A., Salah, W., et al. 2021. Role of selenium in metabolic homeostasis and human reproduction. Nutrients, 13(9), 3256.
• 29. Mutonhodza, B., Joy, E., Bailey, E., et al. 2022. Linkages between soil, crop, livestock, and human selenium status in Sub-Saharan Africa: a scoping review. Int J Food Sci Technol, 57(10), 6336-6349.
• 30. Namkoong, S., Hong, S.P., Kim, M.H., Park, B.C. 2013. Reliability on intra-laboratory and interlaboratory data of hair mineral analysis comparing with blood analysis. Annals of Dermatology, 25(1), 67-72.
• 31. Nasrolahi Shirazi, A., Tiwari, R.K., Oh, D., Sullivan, B., Kumar, A., Beni, Y.A., Parang, K. 2014. Cyclic peptide-selenium nanoparticles as drug transporters. Molecular Pharmaceutics, 11(10), 3631-3641.
• 32. Pandey, G., Singh, A., Deshmukh, L., et al. 2020. Amicellar mediated novel method for the determination of selenium in environmental samples using a chromogenic reagent. Anal Methods, 12(35), 4327-4333.
• 33. Pi, J., Jin, H., Liu, R., Song, B., Wu, Q., Liu, L., Jiang, J., Yang, F., Cai, H., Cai, J. 2013. Pathway of cytotoxicity induced by folic acid modified selenium nanoparticles in MCF-7 cells. Applied Microbiology and Biotechnology, 97(3), 1051-1062.
• 34. Prilepsky, A.Yu., Drozdov, A.S., Bogatyrev, V.A., Staroverov, S.A. 2019. Methods of working with cell cultures and determining the toxicity of nanomaterials. St. Petersburg: ITMO University.
• 35. Ranjbariuan, A., Haghigat, S., Yazdi, M., et al. 2022. Synthetic selenium nanoparticles as co-adjuvant improved responses against methicillin-resistant Staphylococcus aureus. World J Microbiol Biotechnol, 39(1):16.
• 36. Semenova, M.V., Polishchuk, N.P., Chizhikova, D.G. 2019. Dangers associated with excess and deficiency of copper. Young Scientist, 4 (242), 201-202.
• 37. Shahmiri, S., Eghbali, F., Ismaeil, A. ,et al. 2022. Selenium deficiency after bariatric surgey, incidence and symptoms: a systematic review and meta-analysis. Obes Surg, 32(5), 1719-1725.
• 38. Skalny, A., Korobeinikova, T., Zabroda, N., et al. 2023. Interactive effects of obesity and hypertension on patterns of hair essential trace element and mineral content in adult women. Biol Trace Elem Res, 201(10), 4677-4687.
• 39. Skalny, A., Burtseva, T., Salnikova, E., et al. 2019. Geographic variation of environmental, food, and human hair selenium content in an industrial region of Russia. Environ Res, 171, 293-301.
• 40. Skorinova, K.D., Kuzmenko, V.V., Vasilenko, I.A. 2020. The prospect of creating medicines based on selenium nanoparticles (review). Drug Development & Registration, 2, 33-44.
• 41. Wang, Y., Wang, J., Hao, H., Cai, M., Wang, S., Ma, J., Li, Y., Mao, C., Zhang, S. 2016. In vitro and in vivo mechanism of bone tumor inhibition by selenium-doped bone mineral nanoparticles. ACS Nano, 10(11), 9927-9937.
• 42. Xia, Y., You, P., Xu, F., Liu, J., Xing, F. 2015. Novel functionalized selenium nanoparticles for enhanced anti-hepatocarcinoma activity in vitro. Nanoscale Research Letters, 10(1), 1051.
• 43. Xiao, X., Deng, H., Lin, X., et al. 2023. Selenium nanoparticles: properties, preparation methods, and therapeutic applications. Chem Biol Interact, 1(378):110483..
• 44. Xuan, G., Zhang, M., Chen, Y., et al. 2020. Design and characterization of a cancer-targeted drug co-delivery system composed of liposomes and selenium nanoparticles. J Nanosci Nanotechnol, 20(9), 5295-5304.
• 45. Yazdi, M.H., Mahdavi, M., Faghfuri, E., Faramarzi, M.A., Sepehrizadeh, Z., Hassan, Z.M., Gholami, M., Shahverdi, A.R. 2015. The immune response induction by biogenic selenium nanoparticles in mice with breast cancer: Preliminary vaccine model. Iranian Journal of Biotechnology, 13(2), 1-9.
• 46. Yildiz, A., Kaya, Y., Tanriverdi, O. 2019. Effect of the interaction between selenium and zinc on DNA repair in association with cancer prevention. J Cancer Prev, 24(3), 146-154