Establishment and validation of quantitative analysis of multi-components by single-marker for quality assessment of compound danshen preparations

• Autorzy: Xiong W. , Yan R. Q. , Liu Y. N. , Peng S. W. , Jiang Z. Z. , Chai X. , Qi A. D. , Wang Y. F.
• Języki publikacji: EN

Abstrakty

EN

Compound danshen preparations (CDPs) are used clinically for the treatment of cardiovascular and cerebrovascular diseases. By using the quantitative analysis of multi-components by single-marker (QAMS) method, sixteen compounds (danshensu, protocatechuic acid, protocatechuicaldehyde, caffeic acid, rosmarinic acid, lithospermic acid, notoginsenoside R1, salvianolic acid B, ginsenoside Rg1, ginsenoside Re, salvianolic acid A, salvianolic acid C, ginsenoside Rb1, ginsenoside Rd, cryptotanshinone, and tanshinone IIA were quantified on an ACQUITY ultraperformance liquid chromatography (UPLC) HSS T3 column (2.1 × 100 mm, 1.8 μm) with the mobile phase consisting of 0.1% formic acid aqueous solution (A) and acetonitrile (B) using a gradient elution at the flow rate of 0.30 mL/min in 30 min at 30°C, which was also validated by UPLC-diode array detection (DAD) and UPLC-electrospray ionization multistage/mass spectrometry (ESI-MS/MS) for assuring the feasibility and accuracy. Tested by robustness experiment under slightly changeable conditions, the stability of relative correction factor (RCF) proved to be stable, with RSDs below 5.69%, except for notoginsenoside R1 with relative standard deviation (RSD) 7.83%. This reliable and convenient QAMS method resolved the problem of standard substance insufficiency and improved the quality assessment of preparations consisting of complex compounds with different chemical structures, such as CDPs.

Słowa kluczowe

EN

compound danshen preparation; QAMS; robustness; quantification

• Wydawca: University of Silesia in Katowice ; Akademiai Kiado
• Czasopismo: Acta Chromatographica
• Rocznik: 2014
• Tom: Vol. 26, no. 4
• Strony: 695--710
• Opis fizyczny: Bibliogr. 26 poz., rys., tab.

Twórcy

autor

Xiong W.

• Tianjin University of Traditional Chinese Medicine Tianjin State Key Laboratory of Modern Chinese Medicine 300193 Tianjin PR China
• Tianjin University of Traditional Chinese Medicine Tianjin Key Laboratory of TCM Chemistry and Analysis 300193 Tianjin PR China

autor

Yan R. Q.

• Tianjin University of Traditional Chinese Medicine Tianjin State Key Laboratory of Modern Chinese Medicine 300193 Tianjin PR China
• Tianjin University of Traditional Chinese Medicine Tianjin Key Laboratory of TCM Chemistry and Analysis 300193 Tianjin PR China

autor

Liu Y. N.

• Tianjin University of Traditional Chinese Medicine Tianjin State Key Laboratory of Modern Chinese Medicine 300193 Tianjin PR China
• Tianjin University of Traditional Chinese Medicine Tianjin Key Laboratory of TCM Chemistry and Analysis 300193 Tianjin PR China

autor

Peng S. W.

• Tianjin University of Traditional Chinese Medicine Tianjin State Key Laboratory of Modern Chinese Medicine 300193 Tianjin PR China
• Tianjin University of Traditional Chinese Medicine Tianjin Key Laboratory of TCM Chemistry and Analysis 300193 Tianjin PR China

autor

Jiang Z. Z.

• Tianjin University of Traditional Chinese Medicine Tianjin State Key Laboratory of Modern Chinese Medicine 300193 Tianjin PR China
• Tianjin University of Traditional Chinese Medicine Tianjin Key Laboratory of TCM Chemistry and Analysis 300193 Tianjin PR China

autor

Chai X.

• Tianjin University of Traditional Chinese Medicine Tianjin State Key Laboratory of Modern Chinese Medicine 300193 Tianjin PR China
• Tianjin University of Traditional Chinese Medicine Tianjin Key Laboratory of TCM Chemistry and Analysis 300193 Tianjin PR China

autor

Qi A. D.

• Tianjin University of Traditional Chinese Medicine Tianjin State Key Laboratory of Modern Chinese Medicine 300193 Tianjin PR China
• Tianjin University of Traditional Chinese Medicine Tianjin Key Laboratory of TCM Chemistry and Analysis 300193 Tianjin PR China

autor

Wang Y. F.

• Tianjin University of Traditional Chinese Medicine Tianjin State Key Laboratory of Modern Chinese Medicine 300193 Tianjin PR China
• Tianjin University of Traditional Chinese Medicine Tianjin Key Laboratory of TCM Chemistry and Analysis 300193 Tianjin PR China

Bibliografia

• [1] N. Ding, Chin. Trad. Herb. Drugs, 33, 1147 (2002)
• [2] L. Liu and L. Lu, HeilongJiang Med. J., 18, 59 (2005)
• [3] J. Li and Q. Wang, Shanxi J. TCM., 17, 56 (2001)
• [4] J. Wang, L.L. Zhang and G. Wu, Zhongguo Zhong Xi Yi Jie He Za Zhi., 27, 800 (2007)
• [5] D. Liu, J.Y. Tang and L. Yan, Zhongguo Zhong Xi Yi Jie He Za Zhi., 30, 1265 (2010)
• [6] Q.S. Yin, X.D. Wei and Y.P. Song, Zhonghua Xue Ye Xue Za Zhi., 32, 134 (2011)
• [7] National Commission of Chinese Pharmacopoeia, ChP., 1: 904, 906 (2010)
• [8] Y.J. Wei, L.W. Qi, P. Li, H.W. Luo, L. Yi and L.H. Sheng, J. Pharm. Biomed. Anal., 45, 775 (2007)
• [9] L.M. Zhou, M. Chow and Z. Zuo, J. Pharm. Biomed. Anal., 41, 744 (2006)
• [10] Y.J. Wei, S.L. Li and P. Li, Biomed. Chromatogr., 21, 1 (2007)
• [11] A.J. Chen, J.Y. Zhang, C.H. Li, X.F. Chen, Z.D. Hu and X.G. Chen, J. Sep. Sci., 27, 569 (2004)
• [12] A.H. Liu, H. Guo, M. Ye, Y.H. Lin, J.H. Sun and M. Xu et al., J. Chromatogr. A., 1161, 170 (2007)
• [13] M. Liu, Y.G. Li, F. Zhang, L. Yang, G.X. Chou and Z.T. Wang et al., J. Sep. Sci., 30, 2256 (2007)
• [14] Y.J. Wei, P. Li, B. Shu, H.J. Li, Y.R. Peng and Y. Song et al., Biomed. Chromatogr., 21, 797 (2007)
• [15] H.J. Zhang and Y.Y. Cheng, J. Pharm. Biomed. Anal., 40, 429 (2006)
• [16] X. Li, H.L. Liu, P. Li, J.L. Zhou, L.W. Qi and L. Yi et al., J. Sep. Sci., 31, 3156 (2008)
• [17] Z.Y. Zhu, H. Zhang, L. Zhao, X. Dong, X. Li and Y.F. Chai et al., Rapid. Commun. Mass. Spectrom., 21, 1855 (2007)
• [18] J. Cao, L.W. Qi, J. Chen, L. Yi, P. Li and M.T. Ren et al., Biomed. Chromatogr., 23, 397 (2009)
• [19] H.M. Gao, Z.M. Wang, Y.J. Li and Z.Z. Qian, Front. Med., 5, 195 (2011)
• [20] F. Yang, Z.M. Wang, Q.W. Zhang and W.H. Feng, Chin J. Chin Mater Med., 36, 2372 (2011)
• [21] Q. Li, W. Liu, Z.L. Luo and M.H. Yang, Chin J. Chin Mater Med., 37, 824 (2012)
• [22] J.J. Zhu, Z.M. Wang, Y.H. Kuang, Q.W. Zhang, Q.P. Gao and N. MA, Acta Pharmaceutica Sinica., 43, 1211 (2008)
• [23] A.P. Li, X. Yang, Y.H. Ding and J.B. Zhao, Chin J Pharm Anal., 32, 1534 (2012)
• [24] D. Wu, Z.L. Zang, D.Q. Wang and C.Y. Li, Chin Pharm J., 47, 1509 (2012)
• [25] J.J. Hou, W.Y. Wu, J. Da, S. Yao, H.L. Long and Z. Yang et al., J. Chromatogr. A., 1218, 5618 (2011)
• [26] X.Y. Gao, Y. Jiang, J.Q. Lu and P.F. Tu, J. Chromatogr. A., 1216, 2118 (2009)