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Design of the neutron generator for the development of boron neutron capture therapy

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Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
In this article, we present the modern state of development of boron neutron capture therapy (BNCT) for cancer treatment using compact neutron generators. In the introduction we consider the main advantages and problems of the BNCT method, the main approaches and directions for building neutron sources, the development of chemical materials - boron-containing delivery agents and the control of irradiation of malignant tumours and healthy tissues. In the main part of the article we consider the main structures of neutron generators that can be effective for applying in BNCT. The development and building of a prototype of a compact neutron generator is also described.
Rocznik
Strony
124--131
Opis fizyczny
Bibliogr. 16 poz., rys., tab.
Twórcy
  • Nuclear Physics Department, Faculty of Physics, Taras Shevchenko National University of Kyiv, Kyiv, Ukraine
  • Nuclear Physics Department, Faculty of Physics, Taras Shevchenko National University of Kyiv, Kyiv, Ukraine
Bibliografia
  • 1. Ferlay J, Ervik M, Lam F, Colombet M, Mery L, Piñeros M, et al. [Internet] Global Cancer Observatory: Cancer Today. Lyon: International Agency for Research on Cancer, 2020 [cited 2023 Dec 04]. Available from: https://gco.iarc.fr/today.
  • 2. INTERNATIONAL ATOMIC ENERGY AGENCY, Advances in Boron Neutron Capture Therapy, Non-serial Publications, IAEA, Vienna, 2023.
  • 3. INTERNATIONAL ATOMIC ENERGY AGENCY, Current Status of Neutron Capture Therapy, TECDOC 1223, IAEA, Vienna, 2001.
  • 4. Nedunchezhian K, Aswath N, Thiruppathy M, Thirugnanamurthy S. Boron Neutron Capture Therapy - A Literature Review. J Clin Diagn Res. 2016 Dec;10(12): ZE01-ZE04.
  • 5. TAE Life Sciences [Internet] Developing targeted drugs for boron neutron capture therapy to treat refractory cancers, 2021 [cited 2023 Dec 04]. Available from: www.nature.com/biopharmdeal, www.taelifesciences.com.
  • 6. Wang S, Zhang Z, Miao L, Li Y. Boron Neutron Capture Therapy: Current Status and Challenges. Front Oncol. 2022;12:788770. doi: 10.3389/fonc.2022.788770.
  • 7. Malouff TD, Seneviratne DS, Ebner DK, Stross WC, Waddle MR, Trifiletti DM, et al. Boron Neutron Capture Therapy: A Review of Clinical Applications. Front Oncol. 2021;11: 601820. doi: 10.3389/fonc.2021.601820.
  • 8. Jin WH, Seldon C, Butkus M, Sauerwein W, Giap HB. A Review of Boron Neutron Capture Therapy: Its History and Current Challenges. Int J Part Ther. 2022;9(1):71-82. doi: 10.14338/IJPT-22-00002.1.
  • 9. Coghi P, Li J, Hosmane NS, Zhu Y. Next generation of boron neutron capture therapy (BNCT) agents for cancer treatment. Med Res Rev. 2023;43(5):1809-30.
  • 10. Zhang X, Lin Y, Hosmane NS, Zhu Y. Nanostructured boron agents for boron neutron capture therapy: a review of recent patents. Med Rev. 2023; 3(5). doi: 10.1515/mr-2023-0013.
  • 11. Wittig A, Sauerwein WA, Coderre JA. Mechanisms of transport of p-borono-phenylalanine through the cell membrane in vitro. Radiat Res. 2000;153:173-80.
  • 12. Vandenberghe S, Moskal P, Karp J.S. State of the art in total body PET. EJNMMI Phys. 2020;7:35.
  • 13. Alavi A, Werner TJ, Stępień EŁ, Moskal P. Unparalleled and revolutionary impact of PET imaging on research and day to day practice of medicine. Bio-Algorithms and Med-Systems. 2021;17(4):203-12.
  • 14. Moskal SP, Stępień EŁ. Prospects and clinical perspectives of total-body PET imaging using plastic scintillators. PET Clin. 2020;15:439-52.
  • 15. Song ZF, Chen JB, Liu ZJ, Zhan XY, Tang Q. The calibration of DD neutron indium activation diagnostic for Shenguang-III facility, arXiv:1405.2520 [physics.ins-det], e-print 2014.
  • 16. Rasouli FS, Masoudi SF. Design and optimization of a beam shaping assembly for BNCT based on D-T neutron generator and dose evaluation using a simulated head phantom. Appl Radiat Isot. 2012;70:2755.
Uwagi
Opracowanie rekordu ze środków MEiN, umowa nr SONP/SP/546092/2022 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2022-2023).
Typ dokumentu
Bibliografia
Identyfikator YADDA
bwmeta1.element.baztech-3815ad61-79fd-4066-8ee4-6bd81ebfc254
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