Novel s-Triazinyl Schiff Base/Chalcone Congeners: Rational, Synthesis, Antimicrobial and Anti-TB Evaluation

• Autorzy: Lakum H. P. , Shah D. R. , Chikhalia K. H.
• Języki publikacji: EN

Abstrakty

EN

The occurrence of Multi Drug Resistant (MDR) infectious microbial strains has been increased upto alarming level which affects the public health worldwide. To cure this problem, a library of s-triazinyl derivatives comprising schiff base or chalcone motif have been rationalized, synthesized and screened for their in vitro antibacterial activity against five bacterial strains (Staphylococcus aureus MTCC 96, Bacillus subtilis MTCC 441, Escherichia coli MTCC 739, Pseudomonas aeruginosa MTCC 741 and Klebsiella pneumoniae MTCC 109) and four fungal strains (Aspergillus niger MTCC 282, Aspergillus fumigates MTCC 343, Aspergillus clavatus MTCC 1323, Candida albicans MTCC 183) using broth dilution technique. All the newly synthesized scaffolds were further evaluated for their in vitro anti-TB efficacy against the tubercular strain (Mycobacterium tuberculosis H37Rv) using Lowenstein-Jensen MIC method. All the derivatives were well characterized by IR, ¹H NMR, ¹³C NMR, elemental analysis as well as mass spectroscopy.

Słowa kluczowe

EN

antimicrobial; Anti-TB; s-Triazine; Schiff base; Chalcone

• Wydawca: Przedsiębiorstwo Wydawnictw Naukowych "DARWIN"
• Czasopismo: International Letters of Chemistry, Physics and Astronomy
• Rocznik: 2014
• Tom: Vol. 19, iss. 1
• Strony: 56--73
• Opis fizyczny: ibliogr. 20 poz., rys., tab., wz.

Twórcy

autor

Lakum H. P.

• Department of Chemistry, School of Sciences, Gujarat University, Ahmedabed - 380009, Gujarat, India

autor

Shah D. R.

• Department of Chemistry, School of Sciences, Gujarat University, Ahmedabed - 380009, Gujarat, India

autor

Chikhalia K. H.

• Department of Chemistry, School of Sciences, Gujarat University, Ahmedabed - 380009, Gujarat, India

Bibliografia

• [1] World Health Organization. http://www.who.int/mediacentre/factsheets/fs194/en/ (accessed July 17, 2014).
• [2] Centers for Disease Control and Prevention (CDC); Fact Sheet. http://www.cdc.gov/tb/publications/factsheets/drtb/mdrtb.htm (accessed July 17, 2014).
• [3] World Health Organization; Fact sheet N°104. http://www.who.int/mediacentre/factsheets/fs104/en/ (accessed July 17, 2014).
• [4] D. R. Shah, H. P. Lakum, K. H. Chikhalia, International Letters of Chemistry, Physics and Astronomy 17(2) (2014) 207-219.
• [5] H. P. Lakum, D. V. Desai, K. H. Chikhalia, Heterocyclic Communications 19 (2013) 351-355.
• [6] R. V. Patel, P. Kumari, D. P. Rajani, K. H. Chikhalia, European journal of medicinal chemistry 46 (2011) 4354-4365.
• [7] R. Menicagli, S. Samaritani, G. Signore, F. Vaglini, L. Dalla Via, Journal of Medicinal Chemistry 47 (2004) 4649-4652.
• [8] K. Arya, A. Dandia, Bioorganic & medicinal chemistry letters 17 (2007) 3298-3304.
• [9] A. Kumar, K. Srivastava, S. Raja Kumar, S. K. Puri, P. M. Chauhan, Bioorganic & medicinal chemistry letters 19 (2009) 6996-6999.
• [10] X. Chen, P. Zhan, C. Pannecouque, J. Balzarini, E. De Clercq, X. Liu, European journal of medicinal chemistry 51 (2012) 60-66.
• [11] K. Srinivas, U. Srinivas, V. J. Rao, K. Bhanuprakash, K. H. Kishore, U. S. N. Murty, Bioorganic & medicinal chemistry letters 15 (2005) 1121-1123.
• [12] U. P. Singh, R. K. Singh, H. R. Bhat, Y. P. Subhashchandra, V. Kumar, M. K. Kumawat, P. Gahtori, Medicinal Chemistry Research 20 (2011) 1603-1610.
• [13] S. H. Abdel-Hafez, Phosphorus, Sulfur and Silicon 178 (2003) 2563-2579.
• [14] V. R. Avupati, R. P. Yejella, V. R. Parala, K. N. Killari, V. M. R. Papasani, P. Cheepurupalli, V. R. Gavalapu, B. Boddeda, Bioorganic & medicinal chemistry letters 23 (2013) 5968-5970.
• [15] A. Solankee, R. Patel, K. Patel, Chim. Sin 3 (2011) 317-324.
• [16] S. John Joseph, R. Arulkumaran, D. Kamalakkannan, S. P. Sakthinathan, R. Sundararajan, R. Suresh, S. Vijayakumar, K. Ranganathan, N. Kalyanasundaram, G. Vanangamudi, G. Thirunarayanan, International Letters of Chemistry, Physics and Astronomy 4 (2014) 48-65.
• [17] S. John Joseph, R. Arulkumaran, D. Kamalakkannan, S. P. Sakthinathan, R. Sundararajan, R. Suresh, S. Vijayakumar, K. Ranganathan, N. Kalyanasundaram, G. Vanangamudi, G. Thirunarayanan, International Letters of Chemistry, Physics and Astronomy 4 (2014) 48-65.
• [18] S. John Joseph, D. Kamalakkannan, R. Arulkumaran, S. P. Sakthinathan, R. Suresh, R. Sundararajan, S. Vijayakumar, K. Ranganathan, G. Vanangamudi, G. Thirunarayanan, International Letters of Chemistry, Physics and Astronomy 5 (2014) 99-123.
• [19] Nirali S. Mewada, Dhruvin R. Shah, Kishor H. Chikhalia, International Letters of Chemistry, Physics and Astronomy 17(3) (2014) 281-294.
• [20] S. Vijayakumar, R. Arulkumaran, R. Sundararajan, S. P. Sakthinathan, R. Suresh, D. Kamalakkannan, K. Ranganathan, K. Sathiyamoorthy, V. Mala, G. Vanangamudi, G. Thirunarayanan, International Letters of Chemistry, Physics and Astronomy 9(1) (2013) 68-86.