Neurotransmitters detection using a fluorescence-based sensor with graphene quantum dots

• Autorzy: Baluta S. , Cabaj J. , Malecha K.

Identyfikatory

DOI

10.5277/oa170205

• Języki publikacji: EN

Abstrakty

EN

In the paper, the development and performance of an optical sensor for detection of neurotransmitters (dopamine) is presented. The concentration of dopamine is measured basing on fluorescence quenching of graphene quantum dots. In the sensor, the dopamine molecules coat the graphene quantum dots surface – in result, the quenching of fluorescence occurs due to the Förster resonance energy transfer. The changes in fluorescence correspond to specific concentrations of the neurotransmitter in tested samples, so it is possible to accurately determine the concentration of dopamine in the sample.

Słowa kluczowe

EN

sensor; dopamine; fluorescence; Förster resonance energy transfer; quantum dots

• Wydawca: Oficyna Wydawnicza Politechniki Wrocławskiej
• Czasopismo: Optica Applicata
• Rocznik: 2017
• Tom: Vol. 47, nr 2
• Strony: 225--231
• Opis fizyczny: Bibliogr. 10 poz., rys.

Twórcy

autor

Baluta S.

• Wrocław University of Science and Technology, Faculty of Chemistry, Wybrzeże Wyspiańskiego 27, 50-370 Wrocław, Poland

autor

Cabaj J.

• Wrocław University of Science and Technology, Faculty of Chemistry, Wybrzeże Wyspiańskiego 27, 50-370 Wrocław, Poland

autor

Malecha K.

• Wrocław University of Science and Technology, Faculty of Microsystem Electronics and Photonics, Wybrzeże Wyspiańskiego 27, 50-370 Wrocław, Poland

Bibliografia

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• [2] YAN LI, YUE HU, YANG ZHAO, GAOQUAN SHI, LIER DENG, YANBING HOU, LIANGTI QU, An electrochemical avenue to green-luminescent graphene quantum dots as potential electron-acceptors for photovoltaics, Advanced Materials 23(6), 2011, pp. 776–780.
• [3] CHONG WANG, CONGYU WU, XUEJIAO ZHOU, TING HAN, XIAOZHEN XIN, JIAYING WU, JINGYAN ZHANG, SHOUWU GUO, Enhancing cell nucleus accumulation and DNA cleavage activity of anti-cancer drug via graphene quantum dots, Scientific Reports 3, 2013, pp. 2852–2860.
• [4] VENTON J.B., WIGHTMAN M.R., Psychoanalytical electrochemistry: dopamine and behavior. Correlating neurochemical changes in the brain with behavior marks the beginning of an exciting new interdisciplinary field, psychoanalytical chemistry, Analytical Chemistry 75(19), 2003, pp. 414A–421A.
• [5] SHAOHUANG WENG, DONG LIANG, HUAZHANG QIU, ZONGEN LIU, ZHEN LIN, ZONGFU ZHENG, AILIN LIU, WEI CHEN, XINHUA LIN, A unique turn-off fluorescent strategy for sensing dopamine based on formed polydopamine (pDA) using graphene quantum dots (GQDs) as fluorescent probe, Sensors and Actuators B: Chemical 221, 2015, pp. 7–14.
• [6] HELMS V., Principles of Computational Cell Biology, Wiley-VCH, 2008.
• [7] VASUDEV A., KAUSHIK A., JONES K., BHANSALI S., Prospects of low temperature co-fired ceramic (LTCC) based microfluidic systems for point-of-care biosensing and environmental sensing, Microfluidics and Nanofluidics 14(3–4), 2013, pp. 683–702.
• [8] COUCERIO P., GÓMEZ-DE PEDRO S., ALONSO-CHAMARRO J., All-ceramic analytical microsystems with monolithically integrated optical detection microflow cells, Microfluidics and Nanofluidics 18(4), 2015, pp. 649–656.
• [9] CZOK M.J., BEMBNOWICZ P.I., GOLONKA L.J., Low-temperature co-fired ceramics system for light absorbance measurement, International Journal of Applied Ceramic Technology 10(3), 2013, pp. 443–448.
• [10] MALECHA K., The implementation of fluorescence-based detection in LTCC (low-temperature-co-fired -ceramics) microfluidic modules, International Journal of Applied Ceramic Technology 13(1), 2016, pp. 69–77.

Uwagi

Opracowanie ze środków MNiSW w ramach umowy 812/P-DUN/2016 na działalność upowszechniającą naukę (zadania 2017).