Determination of some psychotropic drugs in human plasma by HPTLC

• Autorzy: Wróblewski K. , Petruczynik A. , Waksmundzka-Hajnos M.
• Języki publikacji: EN

Abstrakty

EN

Psychotropic drugs: desipramine, olanzapine and mitrazapine were chromatographed on cyanopropyl-silica and Diol-silica thin layers using various nonaqueous and aqueous eluents.The best results were obtained with addition of ammonia to nonaqueous eluent on both adsorbents. On the basis of the optimization, systems for extraction from human plasma and quantitative determination of investigated drugs were selected.RP18 encaped SPE columns conditioned and pre-eluted with acetonitrile:water:ammonium buffer at pH 8.6 (5:5:2) and eluted with methanol:water (9:1) containing 2% acetic acid were used for sample preparation with high recoveries of all investigated drugs. Diol and CN plates with mixture of 15% methanol in diisopropyl ether + 1% ammonia were used for quantitative analysis by a calibration curve method.

Słowa kluczowe

EN

HPTLC; psychotropic drugs; quantitative analysis; CN; Diol

• Wydawca: University of Silesia in Katowice ; Akademiai Kiado
• Czasopismo: Acta Chromatographica
• Rocznik: 2014
• Tom: Vol. 26, no. 2
• Strony: 297--307
• Opis fizyczny: Bibliogr. 24 poz., rys., tab.

Twórcy

autor

Wróblewski K.

• Medical University of Lublin Department of Inorganic Chemistry 4a Chodźki Str. 20-093 Lublin Poland

autor

Petruczynik A.

• Medical University of Lublin Department of Inorganic Chemistry 4a Chodźki Str. 20-093 Lublin Poland

autor

Waksmundzka-Hajnos M.

• Medical University of Lublin Department of Inorganic Chemistry 4a Chodźki Str. 20-093 Lublin Poland

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