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The effect of hydroxyapatite coating with silver nanoparticles on osseointegration of titanium implants

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
During the implantation surgery, an infection associated with the biofilm formation may occur. Both the type of the introduced material as well as the implant osseointegration largely determine the effectiveness of bone defect treatment. The materials research is increasingly focusing on improving the osseointegration process. A bacterial biofilm can form on any surface of the artificial organ that has been introduced into the body or surrounding tissues. A bacterial infection is one of the most serious complications of implantology surgery leading to serious physiological damage. As proved in the literature, a solution that can prevent bacterial infections is to modify the implant surface by applying an antibacterial coating, while maintaining the material biocompatibility. The article presents the tests results of prototype implants with hydroxyapatite coatings obtained via plasma spraying on titanium surfaces. The resulting coatings were enriched with silver nanoparticles, the content of which was about 2%. The animal model are New Zealand rabbits. The implants were placed in the femur of the animal. The amount of released ions and the force of pulling the implants from the bone were determined. The binding strength between the joint surface and the implant was determined by the mechanical blocking and biological binding of growing bone tissue. In addition, the surface structure of the obtained implants was evaluated. It has been shown that the surface modification of the implants affected the obtained stabilization value, as compared to the implants surface coated only with hydroxyapatite.
Słowa kluczowe
Rocznik
Strony
9--15
Opis fizyczny
Bibliogr. 16 poz., rys., tab., wykr., zdj.
Twórcy
  • Lukasiewicz Research Network - Metal Forming Institute, 14 Jana Pawla II St., 61-139 Poznan, Poland
  • Wiktor Degi Orthopedic and Rehabilitation Clinical Hospital, Karol Marcinkowski Medical University, Department of General Orthopedics, Oncology and Traumatology, 135-147 28 Czerwca 1956 r. St., 61-545 Poznan, Polan
  • Lukasiewicz Research Network - Metal Forming Institute, 14 Jana Pawla II St., 61-139 Poznan, Poland
Bibliografia
  • [1] Gierzyńska-Dolna M., Lijewski M.: Badania tribologicznych właściwości biomateriałów i implantów. Obróbka Plastyczna Metali XXIII Nr 3 (2012).
  • [2] Borkowski L., Pawłowska M., Polkowska I., Karpiński M., Słowik T., Piersisk T., Matuszewski Ł., Ślósarczyk A., Ginalska G.: Histological and radiological analysis of rabbit bones after implan-tation of CHAP-glucan composite. Engineering of Biomaterials 114 (2012) 28-33.
  • [3] Karlsson J., Jimbo R., Fathali H.M, Schwartz-Filho H.O., Hayashi M., Halvarsson M., Wennerberg A., Andersson M.: In vivo biomechani-cal stability of osseointegrating mesoporous TiO2 implants. Acta Biomaterialia 8 (2012) 4438-4446.
  • [4] Dan-Jae L., Chien-Ping J., Shu-Huei H., Yin-Chun T., Hsiang-Shu Y., Wen-Cheng Ch., Jiin-Huey Ch.L.: Mechanical testing and osteointegration of titanium implant with calcium phosphate bone cement and autograft alternatives. Journal of the mechanical be-havior of biomedical materials 4 (2011) 1186-1195.
  • [5] Makuch K., Koczorowski R.: Biokompatybilność tytanu oraz jego stopów wykorzystywanych w stomatologii. Dent. Med. Probl. 47(1) (2010) 81-88.
  • [6] Chung C.J., Su R.T., Chu H.J., Chen H.T., Tsou H.K., He J.L.: Plasma electrolytic oxidation of titanium and improvement in os-seointegration. Journal of Biomedical Materials Research Part B: Applied Biomaterials 101(6) (2013) 1023-1030.
  • [7] Zhang X., Chaimayo W., Yang C., Yao J., Miller B.L., Yates M.Z.: Silver-hydroxyapatite composite coatings with enhanced antimicro-bial activities through heat treatment, Surface & Coatings Technol-ogy 325 (2017) 39-45.
  • [8] Agarwal R., García A.J.: Biomaterial strategies for engineering implants for enhanced osseointegration and bone repair: Advanced Drug Delivery Reviews 94 (2015) 53-62.
  • [9] Speruda M., Kędziora A., Bugla-Płoskońska G.: Antybakteryjne działanie nanocząstek srebra syntetyzowanych metodą zielonej chemii. Medycyna Doświadczalna i Mikrobiologia 69 (2017) 281-288.
  • [10] Song L., Xiao Y.F., Gan L., Wu Y., Wu F., Gu Z.W.: The effectof antibacterial ingredients and coating microstructure on the an-tibacterial properties of plasma sprayed hydroxyapatite coatings. Surface and Coatings Technology 206(11-12) (2012) 2986-2990.
  • [11] Guzman M., Dille J., Godet S.: Synthesis and antibacterial activity of silver nanoparticles against gram-positive and gram-negative bacteria. Nanomedicine: Nanotechnology, Biology, and Medicine 8 (2012) 37-45.
  • [12] Salem W.M., Haridy M., Sayed W.F., Hassan N.H.: Antibacte-rial activity of silver nanoparticles synthesized from latex and leaf extract of Ficus sycomorus. Industrial Crops and Products 62 (2014) 228-234.
  • [13] Ziąbka M., Merta A., Król W., Bobrowski A., Chłopek J.: High Density Polyethylene Containing Antibacterial Silver Nanopar-ticles for medical Applications. Macromolecular Symposia 315 (2012) 218-225.
  • [14] Dubnika A., Loca D., Rudovica V., Bharat Parekh M., Berzina-Cimdina L.: Functionalized silver doped hydroxyapatite scaffolds for controlled simultaneous silver ion and drug delivery. Ceramics International 43(4) (2017) 3698-3705.
  • [15] Li J., Jansen J.A., Walboomers X.F., van den Beucken J.J.: Mechanical aspects of dental implants and osseointegration: A narrative review. Journal of the mechanical behavior of biomedical materials 103 (2020) 103574.
  • [16] Yang Y.Ch., Yang Ch.Y.: Mechanical and histological evaluation of a plasma sprayed hydroxyapatite coating on a titanium bond coat. Ceramics International 39 (2013) 6509-6516.d
Uwagi
Opracowanie rekordu ze środków MNiSW, umowa Nr 461252 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2020).
Typ dokumentu
Bibliografia
Identyfikator YADDA
bwmeta1.element.baztech-35eb3b54-73ee-45d4-b7f5-8126b83954cb
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