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Abstrakty
The author has synthesized azomethines in which carbonyl group is replaced by amine of acid hydrazides. The intermediates were prepared by using 2-mercapto benzimidazole with N-(4-Acetyl-phenyl)-2-chloro-acetamide in the presence of K2CO3. The Resulted product was further treated with different substituted of acid hydrazide in ethanol to yield the titled compounds using a catalytic amount of acetic acid. New products were examined for their antibacterial effects against Gram-positive and Gram-negative strains and antifungal were highly potent with lowest MIC Values. The structural assignments of the new products were done on the basis of FT-IR, NMR, Mass spectroscopy and elemental analysis.
Słowa kluczowe
Rocznik
Tom
Strony
25--33
Opis fizyczny
Bibliogr. 15 poz., tab., wz.
Twórcy
autor
- Department of Chemistry, Sheth M. N. Science College, NGES Campus, Patan - 384265, India
autor
- Department of Chemistry, Sheth M. N. Science College, NGES Campus, Patan - 384265, India
autor
- Department of Chemistry, Sheth M. N. Science College, NGES Campus, Patan - 384265, India
Bibliografia
- [1] Camacho J., Barazarte A., Gamboa N., Rodrigues J., Rojas R., Vaisberg A., Gilman R.,Charris J., Bioorg. & Med. Chem. 19 (2011) 2023-2029.
- [2] Porcari A.R., Devivar R.V., Kucera L.S., Drach J.C., Townsend L.B., J Med Chem 41(1998) 1252-1262.
- [3] Victor F., Brown T.J., Campanale K., Heinz B.A., Shirpley L.A., Su S.K., Tang J.,Vance L.M., Spitzer W., J Med Chem 40 (1997) 1511-1518.
- [4] Ansari K.F., Lal C., Eur. J. Med. Chem. 44 (2009) 4028-4033.
- [5] Hosamani K.S., Shingalapur R.V., Rangappa S., Hugar M.H., Eur J Med Chem 45(2010) 1753-1759.
- [6] Patil A., Ganguly S., Surana S., Rasayan J Chem. 1 (2008) 447-460.
- [7] Deep Joshi, Kalpesh Parikh, Med. Chem. Res. 22 (2012) 3688-3697.
- [8] Kalpesh S. Parikh and Sandip P. Vyas, Archives of Applied Science Res. 4 (2012) 1578-1580.
- [9] Grocer, H., Kus, C., Boykin, D.W., Yildiz, S., Altanlar, N. Synthesis and Anti-fungal Properties of Some Benzimidazole Derivatives. Bioorg. Med. Chem.10 (2002) 2589-2596.
- [10] Nicholson R.M., Murphy J.R., Dearden J.R., Journal of Pharmacy and Pharmacology 34 (1982) 106-111.
- [11] Fang B., Zhou C.H., Rao X.C., Eur. J. Med. Chem. 45 (2010) 4388-4398.
- [12] E. F. Magomedova, V. V. Pinyaskin, A. Sh. Aminova, Pharma. Chem. J. 41 (2007) 474-475.
- [13] Yadav S., Kumar P., Clercq E.D., Balzarini J., Pannecouque C., Dewan S.K.,Narasimhan B., Eur. J. Med. Chem. 45 (2010) 5985-5997.
- [14] John Maria Xavier, M. Arockia Raj, J. Margaret Marie, Journal of Chemical and Pharmaceutical Research 4 (2012) 669-672.
- [15] P.C. Hannan, Vet. Res. 31 (2000) 373-395.
Typ dokumentu
Bibliografia
Identyfikator YADDA
bwmeta1.element.baztech-35bf30af-fb42-46ef-8593-86b59623c17e