Systemy uwalniania leków oparte na nanowłóknach

Nakielski, P.

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Tytuł artykułu

Systemy uwalniania leków oparte na nanowłóknach

Autorzy

Nakielski P.

Treść / Zawartość

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IPPT_Reports_2015_1_P_Nakielski_online_5_March_2015.pdf

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Warianty tytułu

Drug delivery systems based on nanofibers

Języki publikacji

Abstrakty

W pracy podjęto się zadania stworzenia systemu uwalniania leków opartego na zastosowaniu biodegradowalnych materiałów polimerowych wytworzonych z nanowłókien otrzymywanych metodą elektroprzędzenia. Bezpośrednim celem tej pracy było stworzenie aktywnego opatrunku wspomagającego operacje neurochirurgiczne. Praca zawiera eksperymentalną i numeryczną analizę procesu uwalniania i transportu leku do typowego płynu buforowego oraz analogu tkanki mającą na celu znalezienie optymalnych warunków kontrolowania w czasie i przestrzeni rozkładu stężenia leku. Uwalnianie leku w zaproponowanym modelu matematycznym opisano za pomocą równań adsorpcji-desorpcji, zaś transport w porowatym materiale z wykorzystaniem równania dyfuzji. Przedstawiona analiza parametrów materiałów z nanowłókien mających wpływ na szybkość uwalniania leków, opis matematyczny procesu lokalnego uwalniania leków z materiałów polimerowych, jak również transportu substancji aktywnych w organizmie w szczególności w tkance mózgowej, pozwoliły na zbudowanie modelu numerycznego umożliwiającego parametryczną ocenę wpływu czynników geometrycznych, struktury materiału, metody enkapsulacji leku we włóknach, jak i własności nanowłókien na profile uwalniania leków. W rezultacie przeprowadzonych badań stworzono materiały do operacji chirurgicznych oparte na trzech lekach neuroprotektycznych: lipofilowego alfa-tokoferolu, oraz hydrofilowych czynników wzrostu NGF (Nerve Growth Factor) i BDNF (Brain Derived Neurotrophic Factor). Jako nośników leków użyto biodegradowalnych i biokompatybilnych polimerów poli(L-laktydu-co-kaprolaktonu) PLC, poli(L-laktydu) PLLA, poli(DL-laktydu-co-glikolidu) PDLG. Przeprowadzone we współpracy z Instytutem Medycyny Doświadczalnej i Klinicznej PAN operacje neurochirurgiczne wykonane na modelu zwierzęcym potwierdziły pozytywny wpływ wytworzonych z nanowłókien materiałów na proces regeneracji tkanki nerwowej, zapobiegając jednocześnie szkodliwemu dla tego procesu bliznowaceniu tkanki.

In this work the task of preparation of drug release system based on the biodegradable polymeric materials made from nanofibers obtained by electrospinning is presented. The main goal of this work was to create an active dressing for the use in neurosurgery. The work includes experimental and numerical analysis of the release process and transport of the drug to the typical buffer fluid and tissue simulator aimed at finding the optimal conditions to control in time and space the drug concentration distribution. The drug release in proposed mathematical model was described by the adsorption-desorption equation while transport in the porous material by the diffusion equation. Presented analysis of nanofibrous material parameters affecting drug release rate, the mathematical description of the process of local drug release from polymeric materials as well as the transport of active substances in the body, in particular in brain tissue, enabled the construction of a numerical model allowing a parametric evaluation of geometric factors, structure of the material, the drug encapsulation in the fibers, as well as the properties of nanofibers on the drug release profiles. In order to calibrate and validate the numerical model, the experimental system have been proposed to assess transport of the drug analog (rhodamine B and the protein BSA) from the material located in a tissue simulating medium. As a result materials for surgical operations based on three neuroprotective drugs: lipophilic alpha-tocopherol and hydrophilic growth factors NGF (Nerve Growth Factor) and BDNF (Brain Derived Neurotrophic Factor) were developed. As a drug carriers biocompatible biodegradable polymers poly(L-lactideco-caprolactone) PLCL, poly(L-lactide) PLLA, poly(DL-lactide-co-glycolide) PDLG were used. Conducted in collaboration with the Mossakowski Medical Research Centre PAS neurosurgeries performed on an animal model confirmed positive impact of nanofibrous materials on the process of regeneration of nerve tissue, preventing at the same time improper process of tissue scarring.

Słowa kluczowe

nanowłókna uwalnianie leku opatrunek analiza numeryczna

nanofiber biodegradable polymeric material numerical analysis

Wydawca

Instytut Podstawowych Problemów Techniki PAN

Czasopismo

IPPT Reports on Fundamental Technological Research

Rocznik

2015

Tom

nr 1

Strony

2--215

Opis fizyczny

Bibliogr. 161 poz., rys., tab.

Twórcy

autor

Nakielski P.

Instytut Podstawowych Problemów Techniki Polskiej Akademii Nauk

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