Repair of knee cartilage defects with modified carbon fibre implants – preliminary study

• Autorzy: Menaszek E. , Orzelski M. , Silmanowicz P. , Rajzer I. , Błażewicz M.
• Języki publikacji: EN

Abstrakty

EN

The paper presents promising results of our pilot study. The objective of this study was to investigate the effect of modified carbon fibres on cartilage regeneration. Fullthick knee articular cartilage defects in rabbits were filled with equal portions of pure carbon fibres of carbon fibres enriched with hydroxyapatite, hyaluronan or calcium alginate. Historical specimens containing implanted carbon fibres after 4, 8, 16 and 24 weeks from the surgery were prepared. Carbon fibres modified with hydroxyapatite generated bone growth, while those without modification and modified with hyaluronan supported cartilage regeneration.

Słowa kluczowe

EN

knee cartilage; implants; defects

• Wydawca: Polish Society for Biomaterials in Cracow
• Czasopismo: Engineering of Biomaterials
• Rocznik: 2009
• Tom: Vol. 12, no. 88
• Strony: 11--15
• Opis fizyczny: Bibliogr. 15 poz., zdj.

Twórcy

autor

Menaszek E.

• Jagiellonian University, Collegium Medicum, Department of Cytobiology and Histochemistry, 9 Medyczna St, 30-688 Cracow, Poland
• AGH University of Science and Technology, Faculty of Materials Science and Ceramics, Department of Biomaterials, 30 Mickiewicza Ave., 30-059 Cracow

autor

Orzelski M.

• Agricultural University, Faculty of Veterinary Medicine, Department and Clinic of Animal Surgery, 30 Głęboka St., 20-612 Lublin, Poland

autor

Silmanowicz P.

• Agricultural University, Faculty of Veterinary Medicine, Department and Clinic of Animal Surgery, 30 Głęboka St., 20-612 Lublin, Poland

autor

Rajzer I.

• ATH University of Bielsko-Biała, Faculty of Materials and Environmental Sciences, Institute of Textile Engineering and Polymer Science, Department of Polymer Materials, 2 Willowa St., 43-309 Bielsko-Biała, Poland

autor

Błażewicz M.

• AGH University of Science and Technology, Faculty of Materials Science and Ceramics, Department of Biomaterials, 30 Mickiewicza Ave., 30-059 Cracow

Bibliografia

• [1] Salgado AJ, Oliveira JT, Pedro AJ, Reis RL. Adult stem cells in bone and cartilage tissue engineering. Curr Stem Cell res Ther. 2006; 1(3): 345-64.
• [2] Uematsu K, Hattori K, Ishimoto Y, Yamauchi J, Habata T, Takakura Y, Ohgushi H, Fukuchi T, Sato M. Cartilage regeneration using mesenchymal stem cells and a three-dimensional poly-lactic-glycolic acid (PLGA) scaffold. Biomaterials 2005; 26(20): 4273-9.
• [3] Cancedda R, Dozin B, Giannoni P, Quarto R. Tissue engineering and cell therapy and cartilage bone. Matrix Biol. 2003; 22(1): 81-91.
• [4] Hennig A, Abate J. Osteochondral allografts in the treatment of articular cartilage injuries of the knee. Sports Med Anthrosc. 2007; 15(3): 126-32.
• [5] Kamarul T, Selvaratnam L, Masjuddin T, Ab-Rahim S, Ng C, Chan KY, Ahmad TS. Autologous chondrocyte transplantation in the repair of full-thickness focal cartilage damage in rabbits. J Orthop Surg. 2008; 16(2): 230-6.
• [6] Niemeyer P, Pestka JM, Kreuz PC, Erggelet C, Schmal H, Suedkamp NP, Steinwachs M, Characteristic complications after autologous chondrocyte implantation for cartilage defects of the knee joint. Am J Sports Med. 2008; 36(11): 2091-9.
• [7] Malinin TI, Mnaymneh W, Lo HK, Hinkle DK. Cryopreservation of articular cartilage. Ultrastructural observations and long-term results of experimental distal femoral transplantation. Clin Orthop Relat Res. 1994; (303): 18-32.
• [8] Brittberg M, Faxen E, Peterson L. Carbon fibre scaffolds in the treatment of early knee osteoarthritis. Clin Orthop. 1994; 307: 155-64.
• [9] Benke G, Strzelczyk P, Kowalski M, Swiader P. The use of carbon fibers to restore cartilage defects in the knee. Ortop Traumatol Rehabil. 2001 Apr 30; 3(2): 227-9.
• [10] Redman SN, Oldfield SF, Archer CW. Current strategies for articular cartilage repair. Eur Cells and Mat. 2005; 9: 23-32.
• [11] Rajzer I, Frączek A, Błażewicz M. Modyfikowane implanty włókniste do leczenia ubytków tkanek – Modified fibrous implants for tissue regeneration. Eng Biomat. 2006; 58-60: 115-117.
• [12] Kiernan JA. Historical and Histochemical Methods: Theory and practise. Ed. Pergamon Press 1992.
• [13] Carranza-Bencano A, Armas-Padron J, Gili-Miner M, Lozano M. Carbon fiber omplants in osteochondral defects of the rabbit patella. Biomaterials 2000; 21: 2171-6.
• [14] Desai VV, Newman JH. The histology of regenerated tissue after failed carbon fibre matrix implants. The Knee 1999; 6: 229-233.
• [15] Bercovy M, Goutallier D, Voisin MC, Geiger D, Blanquaert D, Gaudichet A, Patte D. Carbon-PLGA prostheses for ligament reconstruction. Clin Orthop. 1985; 196: 159-68.