Fabrication of PLGA/HAp and PLGA/PHB/HAp Fibrous Nanocomposite Materials for Osseous Tissue Regeneration

• Autorzy: Krucińska I. , Chrzanowska O. , Boguń M. , Kowalczuk M. , Dobrzyński P.

Identyfikatory

DOI

10.2478/aut-2014-0006

• Języki publikacji: EN

Abstrakty

EN

The study presents the manufacturing of nanofibrous structures as osteoconductive, osteoinductive materials for osseous tissue regeneration. The fibrous structures were obtained by electrospinning of poly(l-lactide-coglicolide) (PLGA) with addition of hydroxyapatite (HAp) and of a blend of PLGA with polyhydroxybutyrate with HAp added. The polymers used in the experiment were synthesised by an innovative method with a zirconium catalyst. First, the optimal electrospinning process parameters were selected. For the characterisation of the obtained osseous tissue reconstruction materials, the physical, macroscopic, functional, mechanical and thermal properties as well as crystallinity index were studied. The study of the radiation sterilisation influence on average molar mass, thermal and mechanical properties was made in order to analyse the degradation effect.

Słowa kluczowe

EN

electrospinning; resorbable material; implant; osseous tissue regeneration; hydroxyapatite

PL

elektroprzędzenie; materiał resorbowalny; implant; regeneracja tkanki kostnej; hydroksyapatyt

• Wydawca: Lodz University of Technology, Faculty of Material Technologies and Textile Design
• Czasopismo: Autex Research Journal
• Rocznik: 2014
• Tom: Vol. 14, no. 2
• Strony: 95--110
• Opis fizyczny: Bibliogr. 47 poz.

Twórcy

autor

Krucińska I.

• Lodz University of Technology, Faculty of Material Technologies and Textile Design, Department of Material and Commodity Sciences and Textile Metrology, Center of Advanced Technologies of Human Friendly Textiles PRO HUMANO TEX, Lodz, Poland

autor

Chrzanowska O.

• Lodz University of Technology, Faculty of Material Technologies and Textile Design, Department of Material and Commodity Sciences and Textile Metrology, Center of Advanced Technologies of Human Friendly Textiles PRO HUMANO TEX, Lodz, Poland

autor

Boguń M.

• Lodz University of Technology, Faculty of Material Technologies and Textile Design, Department of Material and Commodity Sciences and Textile Metrology, Center of Advanced Technologies of Human Friendly Textiles PRO HUMANO TEX, Lodz, Poland

autor

Kowalczuk M.

• Centre of Polymer and Carbon Materials, Polish Academy of Sciences, Zabrze, Poland

autor

Dobrzyński P.

• Centre of Polymer and Carbon Materials, Polish Academy of Sciences, Zabrze, Poland

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