The effect of cigarette smoking on endothelial damage and atherosclerosis development – modeled and analyzed using Petri nets

• Autorzy: Chmielewska K. , Formanowicz D. , Formanowicz P.

Identyfikatory

DOI

10.1515/acsc-2017-0013

• Języki publikacji: EN

Abstrakty

EN

Atherosclerosis as one of the crucial causes of cardiovascular diseases (CVD) is the leading reason of death worldwide. One of the contributing factors to this phenomenon is endothelial dysfunction, which is associated with the impact of various agents and their interactions. Tobacco smoke is one of the well known factors here. For better understanding of its significance a model of its impact on atherosclerotic plaque formation has been proposed. The model contains selected aspects of the influence of tobacco smoke, dual function of nitric oxide (NO) (influence of various mechanisms on NO bioavailability), oxidative stress which promotes low density lipoproteins oxidation, macrophages significance and other mechanisms leading to an aggravation of the endothelial disturbances. The model has been built using Petri nets theory and the analysis has been based on t-invariants. This approach allowed to confirm the important role of inflammation and oxidative stress in atherosclerosis development and moreover it has shown the considerable influence of the cigarette smoke.

Słowa kluczowe

EN

atherosclerosis; endothelial dysfunction; cigarette smoking; modeling; Petri nets; t-invariants

• Wydawca: Polish Academy of Sciences, Committee of Automatic Control and Robotics
• Czasopismo: Archives of Control Sciences
• Rocznik: 2017
• Tom: Vol. 27, no. 2
• Strony: 211--228
• Opis fizyczny: Bibliogr. 30 poz., rys., schem., tab.

Twórcy

autor

Chmielewska K.

• Institute of Computing Science, Poznan University of Technology, Piotrowo 2, 60-965 Poznan, Poland

autor

Formanowicz D.

• Department of Clinical Biochemistry and Laboratory Medicine, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780 Poznan, Poland

autor

Formanowicz P.

• Institute of Computing Science, Poznan University of Technology, Piotrowo str. 2, 60-965 Poznan and Institute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego str. 12/14, 61-704 Poznan, Poland

Bibliografia

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Uwagi

PL

Opracowanie ze środków MNiSW w ramach umowy 812/P-DUN/2016 na działalność upowszechniającą naukę (zadania 2017).