Characteristics of the Porous Structure Developed Through Additive Manufacturing using Polyamide for Tissue Engineering Applications

• Autorzy: Sikora Szymon , Bednarczyk Ewa , Grygoruk Roman , Fabijański Mariusz , Aniszewicz Andrzej

Identyfikatory

DOI

10.12913/22998624/190128

• Języki publikacji: EN

Abstrakty

EN

Additive manufacturing methods give the opportunity to produce interesting, new structures with a more complicated topology than would be possible using traditional methods. Methods: Using the selective laser sintering method, a disk with a high roughness and porous structure was produced. Studies of material surface were performed on microscopic devices. An in vitro experiment was performed on the manufactured disk using mice fibroblastic cells. Results: The designed shape enabled the growth of the cell culture in the disc pores and ensured impermeability of the disc base. Based on average viability 79%, which is close to reference well (80%), preliminary results confirmed that the manufactured structures create sufficiently comfortable conditions for the cell cultures without the need to design its internal topography. Conclusions: Controlling the production parameters of SLS printing allows to obtain structures characterized by spatial and surface porosity without designing inner geometry of the structure. Polyamide 2200 (PA2200) powder with a laser beam, offers new possibilities for producing surfaces used in the tissue engineering, bioreactors, and microfluidics devices.

Słowa kluczowe

EN

cell culture; 3D printing; SLS method; biomechanical engineering

• Wydawca: Lublin University of Technology ; Polish Society of Ecological Engineering (PTIE), Branch of PTIE in Lublin
• Czasopismo: Advances in Science and Technology. Research Journal
• Rocznik: 2024
• Tom: Vol. 18, no 5
• Strony: 90--100
• Opis fizyczny: Bibliogr. 44 poz., fig., tab.

Twórcy

autor

Sikora Szymon

• Faculty of Mechanical and Industrial Engineering, Department of Machine Construction and Biomedical Engineering, Warsaw University of Technology, ul. Narbutta 85, 02-524, Warsaw, Poland

• https://orcid.org/0000-0002-7412-5717

autor

Bednarczyk Ewa

• Faculty of Mechanical and Industrial Engineering, Department of Machine Construction and Biomedical Engineering, Warsaw University of Technology, ul. Narbutta 85, 02-524, Warsaw, Poland

• https://orcid.org/0000-0002-3401-7543

autor

Grygoruk Roman

• Faculty of Mechanical and Industrial Engineering, Department of Machine Construction and Biomedical Engineering, Warsaw University of Technology, ul. Narbutta 85, 02-524, Warsaw, Poland

• https://orcid.org/0000-0003-4357-7873

autor

Fabijański Mariusz

• Faculty of Mechanical and Industrial Engineering, Plastics Processing Department, Warsaw University of Technology, Narbutta 85, 02-524, Warsaw, Poland

• https://orcid.org/0000-0001-6606-3416

autor

Aniszewicz Andrzej

• Railway Institute, Metrology Laboratory, ul. Chłopickiego Józefa 50, Warsaw, Poland

• https://orcid.org/0000-0001-7023-6180

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Uwagi

Opracowanie rekordu ze środków MNiSW, umowa nr SONP/SP/546092/2022 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2024).