Validation and quantification of a UPLC-MS/MS method for the simultaneous determination of quinocetone and its main metabolites (3-methylquinoxaline-2-carboxylic acid and dedioxoquinenone) in aquatic products

• Autorzy: Tian Xiuhui , Han Dianfeng , Cui Yanmei , Ren Lihua , Jiang Fang , Huang Hui , Gong Xianghong , Xue Jinglin , Li Jiawei , Liu Huihui , Xu Yingjiang , Luo Xiaojun , Liu Xiaojing , Zhang Xiuzhen

Identyfikatory

DOI

10.1556/1326.2022.01001

• Języki publikacji: EN

Abstrakty

EN

A sensitive and validated method for determining quinocetone and its main metabolites (3-methylquinoxaline-2-carboxylic acid and dedioxoquinenone) was established in aquatic products using ultra-high-performance liquid chromatography-tandem spectrometry (UHPLC-MS/MS). Samples were extracted with 2.0 mol L⁻¹ hydrochloric acid, then purified on MAX columns. After extraction and purification, the supernatant was evaporated to dry nearly under a gentle stream of nitrogen at 40 °C. Formic acid-acetonitrile-water (0.1/30/70, v/v/v) was adjusted to 1.00 mL final volume. An aliquot (10 μL) was injected into the C₁₈ column for separation with the mobile phase of acetonitrile and 0.5% formic acid in water at 0.25 mL min⁻¹. Calibration curves were linear ranged from 10.00 ng mL⁻¹ to 200.0 ng mL⁻¹ for quinocetone and 3-methylquinoxaline-2-carboxylic acid, and 20.00 ng mL⁻¹ to 400.0 ng mL⁻¹ for dedioxoquinenone. Mean recoveries were 70%–89%, 73%–83% and 72%–84%, respectively. The limit of detection (LOD) was 1.00 μg kg⁻¹, 1.00 μg kg⁻¹ and 2.00 μg kg⁻¹, and quantification (LOQ) were 2.00 μg kg⁻¹, 2.00 μg kg⁻¹ and 4.00 μg kg⁻¹ for quinocetone, 3-methylquinoxaline-2-carboxylic acid, and dedioxoquinenone. Based on the method above, the analytes were determined in Apostichopus japonicus, three fishes (including Ctenopharyngodon idellus, Crucian carp and Oreochromis mossambicus), Penaeus vannamei, Penaeus chinensis, and Chlamys farreri. The method shows good sensitivity, linearity, precision, and accuracy. In short, the proposed method was reliable for the determination of quinocetone, 3-methylquinoxaline-2-carboxylic acid, and dedioxoquinenone in aquatic products.

Słowa kluczowe

EN

quinocetone; metabolite; UHPLC-MS/MS; aquatic product; Apostichopus japonicus

• Wydawca: University of Silesia in Katowice ; Akademiai Kiado
• Czasopismo: Acta Chromatographica
• Rocznik: 2022
• Tom: Vol. 34, no. 4
• Strony: 444--452
• Opis fizyczny: Bibliogr. 29 poz., tab., rys., wykr.

Twórcy

autor

Tian Xiuhui

• Shandong Marine Resource and Environment Research Institute, Shandong Key Laboratory of Marine Ecological Restoration, Yantai, 264006, China

autor

Han Dianfeng

• Shandong Marine Resource and Environment Research Institute, Shandong Key Laboratory of Marine Ecological Restoration, Yantai, 264006, China

autor

Cui Yanmei

• Shandong Marine Resource and Environment Research Institute, Shandong Key Laboratory of Marine Ecological Restoration, Yantai, 264006, China

autor

Ren Lihua

• Shandong Marine Resource and Environment Research Institute, Shandong Key Laboratory of Marine Ecological Restoration, Yantai, 264006, China

autor

Jiang Fang

• Shandong Marine Resource and Environment Research Institute, Shandong Key Laboratory of Marine Ecological Restoration, Yantai, 264006, China

autor

Huang Hui

• Shandong Marine Resource and Environment Research Institute, Shandong Key Laboratory of Marine Ecological Restoration, Yantai, 264006, China

autor

Gong Xianghong

• Shandong Marine Resource and Environment Research Institute, Shandong Key Laboratory of Marine Ecological Restoration, Yantai, 264006, China

autor

Xue Jinglin

• Shandong Marine Resource and Environment Research Institute, Shandong Key Laboratory of Marine Ecological Restoration, Yantai, 264006, China

autor

Li Jiawei

• Shandong Marine Resource and Environment Research Institute, Shandong Key Laboratory of Marine Ecological Restoration, Yantai, 264006, China

autor

Liu Huihui

• Shandong Marine Resource and Environment Research Institute, Shandong Key Laboratory of Marine Ecological Restoration, Yantai, 264006, China

autor

Xu Yingjiang

• Shandong Marine Resource and Environment Research Institute, Shandong Key Laboratory of Marine Ecological Restoration, Yantai, 264006, China

autor

Luo Xiaojun

• Guangdong Provincial Key Laboratory of Environmental Protection and Resources Utilization, Guangzhou Institute of Geochemistry, Chinese Academy of Science, Guangzhou, 510640, China

autor

Liu Xiaojing

• Shandong Marine Resource and Environment Research Institute, Shandong Key Laboratory of Marine Ecological Restoration, Yantai, 264006, China

• https://orcid.org/0000-0002-5522-244X

autor

Zhang Xiuzhen

• Shandong Marine Resource and Environment Research Institute, Shandong Key Laboratory of Marine Ecological Restoration, Yantai, 264006, China

• https://orcid.org/0000-0003-3972-8077

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Uwagi

Opracowanie rekordu ze środków MEiN, umowa nr SONP/SP/546092/2022 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2022-2023).