Ftalan bis(2-etyloheksylu). Dokumentacja proponowanych dopuszczalnych wielkości narażenia zawodowego

Stragierowicz, Joanna; Klimczak, Michał; Bruchajzer, Elżbieta

doi:10.54215/PiMOSP/2.110.2021

Artykuł - szczegóły

Tytuł artykułu

Ftalan bis(2-etyloheksylu). Dokumentacja proponowanych dopuszczalnych wielkości narażenia zawodowego

Autorzy

Stragierowicz Joanna , Klimczak Michał , Bruchajzer Elżbieta

Treść / Zawartość

Pełne teksty:

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Identyfikatory

DOI

10.54215/PiMOSP/2.110.2021

Warianty tytułu

Bis(2-ethylhexyl) phthalate. Documentation of proposed values of occupational exposure limits (OELs)

Języki publikacji

Abstrakty

Ftalan bis(2-etyloheksylu) (DEHP) był powszechnie stosowany w przeszłości, głównie jako plastyfikator. Narażenie zawodowe na DEHP występuje w czasie jego produkcji oraz stosowania, zaś narażenie środowiskowe jest związane z produktami zawierającymi ten związek oraz ze spożywaniem zanieczyszczonej żywności lub wody. Unia Europejska wprowadziła zakaz obrotu produktów zawierających DEHP w stężeniu ≥0,1%. Wchłanianie tego flatalanu może zachodzić drogą pokarmową i inhalacyjną, przechodzi on również przez barierę łożyskową oraz do mleka matki. Dane epidemiologiczne wskazują na związek między narażeniem na DEHP (zarówno zawodowym, jak i środowiskowym) a funkcjonowaniem męskiego układu rozrodczego. Nie wykazano bezpośredniej zależności między narażeniem na DEHP a bezpłodnością. W badaniach na zwierzętach za najczulszy skutek toksyczności przewlekłej tego związku uznano zaburzenia spermatogenezy u szczurów. Jako podstawę do zaproponowania wartości NDS dla ftalanu bis(2-etyloheksylu) przyjęto toksyczne działanie na męski układ rozrodczy obserwowane u szczura (NOAEL = 5,8 mg/kg mc./dzień). Proponuje się przyjęcie wartości NDS dla ftalanu bis(2-etyloheksylu) na poziomie 0,8 mg/m³ Brak jest podstaw do ustalenia wartości NDSCh oraz DSB. Proponuje się notację „Ft” – substancja działająca szkodliwie na rozrodczość. Z powodu niewielkiego wchłaniania DEHP drogą dermalną brak jest podstaw do przyjęcia notacji „skóra”. Zakres tematyczny artykułu obejmuje zagadnienia zdrowia oraz bezpieczeństwa i higieny środowiska pracy będące przedmiotem badań z zakresu nauk o zdrowiu i inżynierii środowiska

Bis(2-ethylhexyl) phthalate (DEHP) has been widely used in the past mainly as a plasticizer. Occupational exposure to DEHP occurs during its production and use, and environmental exposure is related to products containing DEHP and contaminated food/water. The European Union has banned products containing DEHP in concentrations ≥0.1%. Absorption of DEHP may occur via the oral and inhalation routes. DEHP crosses the placental barrier and passes into breast milk. Epidemiological data indicate an association between DEHP occupational and environmental exposures and male reproductive function. However, no direct relationship between DEHP exposure and infertility can be identified. In animal studies, impaired spermatogenesis in rats has been considered as the most sensitive effect of chronic toxicity of DEHP. The proposed MAC value for bis(2-ethylhexyl) phthalate (0.8 mg/m³) is based on toxic effects on the male reproductive system demonstrated in a chronic study on rats (NOAEL = 5.8 mg/kg bw/day). There is no basis for setting the STEL value (no local irritation) and BEI value. Due to the low dermal absorption of DEHP there is no basis for a “skin” notation, but “R” notation is required (toxic to reproduction). This article discusses the problems of occupational safety and health, which are covered by health sciences and environmental engineering.

Słowa kluczowe

ftalan bis(2-etyloheksylu) DEHP toksyczność narażenie zawodowe NDS nauki o zdrowiu inżynieria środowiska

bis(2-ethylhexyl) phthalate DEHP toxicity occupational exposure MAC health sciences environmental engineering

Wydawca

Centralny Instytut Ochrony Pracy - Państwowy Instytut Badawczy

Czasopismo

Podstawy i Metody Oceny Środowiska Pracy

Rocznik

2021

Tom

Nr 4 (110)

Strony

33--130

Opis fizyczny

Bibliogr. 338 poz., rys., tab.

Twórcy

autor

Stragierowicz Joanna

Uniwersytet Medyczny w Łodzi Zakład Toksykologii 90-151 Łódź, ul. J. Muszyńskiego 1 POLAND

https://orcid.org/0000-0002-9196-0669

autor

Klimczak Michał

Uniwersytet Medyczny w Łodzi Medical University of Lodz, Poland

https://orcid.org/0000-0003-4779-9019

autor

Bruchajzer Elżbieta

Uniwersytet Medyczny w Łodzi Medical University of Lodz, Poland

https://orcid.org/0000-0002-4494-5722

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Opracowanie rekordu ze środków MEiN, umowa nr SONP/SP/546092/2022 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2022-2023).

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