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Properties of bilayer gelatin/polycaprolactone scaffolds

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Języki publikacji
EN
Abstrakty
EN
In this study, nanofibrous composite scaffolds have been fabricated in order to mimic the physical architecture of native extracellular matrix. Gelatin is a good candidate to mimic the chemical composition of natural collagen. It has many integrin-binding sites for cell adhesion and differentiation, which are found in collagen. However, electrospun scaffold made of gelatin had very poor mechanical properties. Therefore, in this study, bilayer nanofibrous scaffolds made of gelatin and poly(caprolactone) were produced by sequential electrospinning. The microscopic morphology, mechanical properties and porosity of electrospun bilayer gelatin/polycaprolactone scaffold were investigated.
Słowa kluczowe
Rocznik
Strony
2--4
Opis fizyczny
Bibliogr. 15 poz., tab., wykr., zdj.
Twórcy
autor
  • ATH, University of Bielsko-Biała, Faculty of Materials and Environmental Sciences, Institute of Textile Engineering and Polymer Materials, Department of Polymer Materials, Willowa 2, 43-309 Bielsko-Biała, Poland
Bibliografia
  • [1] Meng Z.X., Wang Y.S., Ma C., Zheng W., Li L., Zheng Y.F.. Electrospinning of PLGA/gelatin randomly-oriented and aligned nanofibers as potential scaffold in tissue engineering. Materials Science and Engineering C 30 (2010) 1204-1210.
  • [2] Huang Z.M., Zhang Y.Z., Ramakrishna S., Lim C.T. Electrospinning and mechanical characterization of gelatin nanofibers. Polymer 45 (2004) 5361-5368.
  • [3] Ghasemi-Mobarakeh L., Prabhakaran M.P., Morshed M., Nasr-Esfahani M.H., Ramakrishna S.. Electrospun poly(ε-caprolac-tone)/gelatine nanofibrous scaffold for nerve tissue engineering. Biomaterials 29 (2008) 4532-4539.
  • [4] Liu X., Ma P.X.: Phase separation, pore structure and properties of nanofibrous gelatin scaffolds. Biomaterials 30 (2009) 4094-4103.
  • [5] Kejing A., Haiying L., Shidong G., Kumar D.N.T., Qingqing W.: Preparation of fish gelatin/poly(L-lactide) nanofibers by electro-spinning. International Journal of Biological Macromolecules 47 (2010) 380-388.
  • [6] Sell S.A., MacClure M.J., Garg K., Wolfe P.S., Bowlin G.L.: Electrospinning of collagen/biopolymers for regenerative medicine and cardiovascular tissue engineering. Advanced Drug Delivery Reviews 61 (2009) 1007-1019.
  • [7] Chen J.P., Su C.H.: Surface modification of electrospun PLLA nanofibers by plasma treatment and cationized gelatin immobilization for cartilage tissue engineering. Acta Biomaterialia 7 (2011) 234-243.
  • [8] Lee J., Tae G., Kim Y.H., Park I.S., Kim S.H., Kim S.H.: The effect of gelatin incorporation into electrospun poly(L-lactide-co-ε-caprolactone) fibers on mechanical properties and cytocom-patibility. Biomaterials 29 (2008) 1872-1879.
  • [9] Panzavolta S., Gioffre M., Focarete M.L., Gualandi C., Foroni L., Bigi A.: Electrospun gelatin nanofibers: optimization of genipin crosslinking to preserve fiber morphology after exposure to water. Acta Biomaterialia 7 (2010) 1702-1709.
  • [10] Shor L., Guceri S., Chang R., Gordon J., Kang Q., Hartsock L., An Y., Sun W.: Precision extruding deposition (PED) fabrication of polycaprolactone (PCL) scaffolds for bone tissue engineering. Biofabrication 1 (2009) 1-9.
  • [11] Fabbri P., Bondioli F., Messori M., Bartoli C., Dinucci D., Chiellini F.: Porous scaffolds of polycaprolactone reinforced with in situ generated hydroxyapatite for bone tissue engineering. Journal of Materials Science: Materials in Medicine 21 (2010) 343-351.
  • [12] Liu X., Smith L.A., Hu J., Ma P.X.: Biomimetic nanofibrous gelatin/apatite composite scaffolds for bone tissue engineering. Biomaterials 30 (2009) 2252-2258.
  • [13] Bhardwaj N., Kundu S.C.: Electrospinning: A fascinating fibre fabrication technique. Biotechnology Advances 28 (2010) 325-347.
  • [14] Agarwal S., Wendorff J.H., Greiner A.: Use of electrospinning technique for biomedical applications. Polymer 49 (2008) 5603-5621.
  • [15] Rajzer I., Chrzanowski W., Binias W., Sarna E., Janicki J.: Biomimetic fibrous composite membranes for bone tissue engineering. Engineering of Biomaterials 93 (2010) 2-5.
Typ dokumentu
Bibliografia
Identyfikator YADDA
bwmeta1.element.baztech-2cded162-adaa-45d0-bdcf-27c5d775709f
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