The relationship between expression of VIMENTIN and CD146 genes in breast cancer

• Autorzy: Kocemba-Pilarczyk Kinga A. , Dudzik Paulina , Leśkiewicz Katarzyna

Identyfikatory

DOI

10.1515/bams-2020-0058

• Języki publikacji: EN

Abstrakty

EN

Objectives: CD146 is an adhesive molecule that was originally reported on malignant melanoma cells as a protein crucial for cell adhesion. It is now known that high expression of the CD146 protein is not only characteristic of melanoma, but it occurs on a number of cancers, contributing to worse prognosis and increased aggressiveness. Independent in vitro studies in breast cancer have shown that CD146 protein alone can induce a change in epithelial to mesenchymal transcriptional profile, which is the basis of the tumor aggressiveness and metastasis. Methods: In the following work, the correlation coefficients were analyzed between the genes of the mesenchymal profile and the CD146 gene in 10 independent transcriptomic data of breast cancer patients. Results: The analysis confirmed the relationship between CD146 expression and mesenchymal profile genes, pointing VIMENTIN as the gene which expression is most strongly correlated with the CD146, suggesting that both genes, CD146 and VIM may be directly controlled by the same mechanism or regulate one another. Conclusions: The analysis points a potential route for research on the CD146 gene expression, which may lead to understanding of its regulation in breast cancer, contributing to the development of new therapeutic strategies targeting highly metastatic breast cancer cells.

Słowa kluczowe

EN

CD146; MCAM; MUC-18; EMT; vimentin

• Wydawca: Uniwersytet Jagielloński - Collegium Medicum ; Index Copernicus Sp. z o.o.
• Czasopismo: Bio-Algorithms and Med-Systems
• Rocznik: 2021
• Tom: Vol. 17, no. 1
• Strony: 1--7
• Opis fizyczny: Bibliogr. 14 poz., rys., tab.

Twórcy

autor

Kocemba-Pilarczyk Kinga A.

• Chair of Medical Biochemistry, Faculty of Medicine, Jagiellonian University - Medical College, Krakow, Poland, Phone: [phone]

• https://orcid.org/0000-0002-7119-2412

autor

Dudzik Paulina

• Chair of Medical Biochemistry, Faculty of Medicine, Jagiellonian University - Medical College, Krakow, Poland

autor

Leśkiewicz Katarzyna

• Office of Institutional Analysis, Jagiellonian University, Krakow, Poland

Bibliografia

• 1. Zeng P, Li H, Lu PH, Zhou LN, Tang M, Liu CY, et al. Prognostic value of CD146 in solid tumor: a systematic review and meta-analysis. Sci Rep 2017;7:4223.
• 2. Zabouo G, Imbert AM, Jacquemier J, Finetti P, Moreau T, Esterni B, et al. CD146 expression is associated with a poor prognosis in human breast tumors and with enhanced motility in breast cancer cell lines. Breast Cancer Res 2009;11:R1.
• 3. Zeng Q, Li W, Lu D, Wu Z, Duan H, Luo Y, et al. CD146, an epithelial-mesenchymal transition inducer, is associated with triple-negative breast cancer. Proc Natl Acad Sci U S A 2012;109: 1127-32.
• 4. Felipe Lima J, Nofech-Mozes S, Bayani J, Bartlett JM. EMT in breast carcinoma - A review. J Clin Med 2016;5. https://doi.org/10.3390/ jcm5070065.
• 5. Brabletz T, Kalluri R, Nieto MA, Weinberg RA. EMT in cancer. Nat Rev Canc 2018;18:128-34.
• 6. Wang Z, Yan X. CD146, a multi-functional molecule beyond adhesion. Canc Lett 2013;330:150-62.
• 7. Kocemba KA, Dudzik P, Ostrowska B, Laidler P. Incorrect analysis of MCAM gene promoter methylation in prostate cancer. Prostate 2016;76:1464-5.
• 8. Dudzik P, Trojan SE, Ostrowska B, Lasota M, Dulińska-Litewka J, Laidler P, et al. Aberrant promoter methylation may be responsible for the control of CD146 (MCAM) gene expression during breast cancer progression. Acta Biochim Pol 2019;66:619-25.
• 9. Dudzik P, Trojan SE, Ostrowska B, Zemanek G, Dulinska-Litewka J, Laidler P, et al. The epigenetic modifier 5-Aza-2-deoxycytidine triggers the expression of CD146 gene in prostate cancer cells. Anticancer Res 2019;39:2395-403.
• 10. Kennecke H, Yerushalmi R, Woods R, Cheang MC, Voduc D, Speers CH, et al. Metastatic behavior of breast cancer subtypes. J Clin Oncol 2010;28:3271-7.
• 11. Zeng Q, Zhang P, Wu Z, Xue P, Lu D, Ye Z, et al. Quantitative proteomics reveals ER-α involvement in CD146-induced epithelial-mesenchymal transition in breast cancer cells. J Proteomics 2014;103:153-69.
• 12. Ingthorsson S, Andersen K, Hilmarsdottir B, Maelandsmo GM, Magnusson MK, Gudjonsson T. HER2 induced EMT and tumorigenicity in breast epithelial progenitor cells is inhibited by coexpression of EGFR. Oncogene 2016;35:4244-55.
• 13. Ma Y, Zhang H, Xiong C, Liu Z, Xu Q, Feng J, et al. CD146 mediates an E-cadherin-to-N-cadherin switch during TGF-β signaling-induced epithelial-mesenchymal transition. Canc Lett 2018;430:201-14.
• 14. Liu CY, Lin HH, Tang MJ, Wang YK. Vimentin contributes to epithelialmesenchymal transition cancer cell mechanics by mediating cytoskeletal organization and focal adhesion maturation. Oncotarget 2015;6:15966-83.

Uwagi

Opracowanie rekordu ze środków MNiSW, umowa Nr 461252 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2021).