A numerical study on the effect of conductivity change in cell kill distribution in irreversible electroporation

• Autorzy: Khorasani Amir

Identyfikatory

DOI

10.2478/pjmpe-2020-0008

• Języki publikacji: EN

Abstrakty

EN

Introduction: irreversible electroporation (IRE) is a tissue ablation technique and physical process used to kill the undesirable cells. In the IRE process by mathematical modelling we can calculate the cell kill probability and distribution inside the tissue. The purpose of the study is to determine the influence of electric conductivity change in the IRE process into the cell kill probability and distribution. Methods: cell death probability and electric conductivity were calculated with COMSOL Multiphysics software package. 8 pulses with a frequency of 1 Hz, pulse width of 100 μs and electric field intensity from 1000 to 3000 V/Cm with steps of 500 V/Cm used as electric pulses. Results: significantly, the electrical conductivity of tissue will increase during the time of pulse delivery. According to our results, electrical conductivity increased with an electric field intensity of pulses. By considering the effect of conductivity change on cell kill probability, the cell kill probability and distribution will change. Conclusion: we believe that considering the impact of electric conductivity change on the cell kill probability will improve the accuracy of treatment outcome in the clinic for treatment with IRE.

Słowa kluczowe

EN

electroporation; finite element analysis; electric conductivity; Peleg-Fermi; pulsed electric field

• Wydawca: Polskie Towarzystwo Fizyki Medycznej ; De Gruyter
• Czasopismo: Polish Journal of Medical Physics and Engineering
• Rocznik: 2020
• Tom: Vol. 26, Iss. 2
• Strony: 69--76
• Opis fizyczny: Bibliogr. 36 poz., rys., tab.

Twórcy

autor

Khorasani Amir

• Department of Medical Physics, School of Medical Sciences, Isfahan University of Medical Science, Isfahan, Iran

Bibliografia

• [1] Weaver JC. Electroporation: a general phenomenon for manipulating cells and tissues. Journal of Cellular Biochemistry. 1993;51(4):426-435.
• [2] Weaver JC, Chizmadzhev YA. Theory of electroporation: a review. Bioelectrochemistry and Bioenergetics. 1996;41(2):135-160.
• [3] Kotnik T, Kramar P, Pucihar G, et al. Cell membrane electroporation-Part 1: The phenomenon. IEEE Electrical Insulation Magazine. 2012;28(5):14-23.
• [4] Weaver JC. Electroporation of cells and tissues. IEEE Transactions on Plasma Science. 2000;28(1):24-33.
• [5] Edhemovic I, Brecelj E, Gasljevic G, et al. Intraoperative electrochemotherapy of colorectal liver metastases. Journal of Surgical Oncology. 2014;110(3):320-327.
• [6] Appelbaum L, Ben-David E, Sosna J, et al. US findings after irreversible electroporation ablation: radiologic-pathologic correlation. Radiology. 2012;262(1):117-125.
• [7] Ben-David E, Appelbaum L, Sosna J, et al. Characterization of irreversible electroporation ablation in in vivo porcine liver. American Journal of Roentgenology. 2012;198(1):W62-W68.
• [8] Rubinsky B. Irreversible electroporation in medicine. Technology in Cancer Research & Treatment. 2007;6:255-259.
• [9] Lu DS, Kee ST, Lee W. Irreversible electroporation: ready for prime time? Techniques in Vascular and Interventional Radiology. 2013;16(4):277-286.
• [10] Rubinsky B, Onik G, Mikus P. Irreversible electroporation: a new ablation modality—clinical implications. Technology in Cancer Research & Treatment. 2007;6:37-48.
• [11] Onik G, Mikus P, Rubinsky B. Irreversible electroporation: implications for prostate ablation. Technology in Cancer Research & Treatment. 2007;6:295-300.
• [12] Chu KF, Dupuy DE. Thermal ablation of tumours: biological mechanisms and advances in therapy. Nature Reviews Cancer. 2014;14(3):199-208.
• [13] Ahmed M, Brace CL, Lee Jr FT, Goldberg SN. Principles of and advances in percutaneous ablation. Radiology. 2011;258(2):351-369.
• [14] Garcia PA, Rossmeisl JH, Neal RE, et al. A parametric study delineating irreversible electroporation from thermal damage based on a minimally invasive intracranial procedure. Biomedical Engineering Online. 2011;10;34.
• [15] Huang K, Tian H, Gai L, Wang J. A review of kinetic models for inactivating microorganisms and enzymes by pulsed electric field processing. Journal of Food Engineering. 2012;111(2):191-207.
• [16] Peleg. Advanced quantitative microbiology for foods and biosystems: models for predicting growth and inactivation: CRC Press, 2006.
• [17] Golberg A, Rubinsky B. A statistical model for multidimensional irreversible electroporation cell death in tissue. Biomedical Engineering Online. 2010;9:13.
• [18] Dermol J, Miklavcic D. Predicting electroporation of cells in an inhomogeneous electric field based on mathematical modeling and experimental CHO-cell permeabilization to propidium iodide determination. Bioelectrochemistry. 2014;100:52-61.
• [19] Garcia PA, Davalos RV, Miklavcic C. A numerical investigation of the electric and thermal cell kill distributions in electroporationbased therapies in tissue. PLoS One. 2014;9:e103083.
• [20] Miklavcic D, Corovic S, Pucihar G, Pavselj N. Importance of tumour coverage by sufficiently high local electric field for effective electrochemotherapy. European Journal of Cancer Supplements. 2006;4(11):45-51.
• [21] Adeyanju OO, Al-Angari HM, Sahakian AV. The optimization of needle electrode number and placement for irreversible electroporation of hepatocellular carcinoma. Radiol Oncol. 2012;46(2):126-35.
• [22] Dunki-Jacobs EM, Philips P, Martin 2nd RC. Evaluation of resistance as a measure of successful tumor ablation during irreversible electroporation of the pancreas. J Am Coll Surg. 2014;218(2):179-87.
• [23] Moisescu MG, Radu M, Kovacs E, et al. Changes of cell electrical parameters induced by electroporation. A dielectrophoresis study. Biochim Biophys Acta. 2013;1828:365-72.
• [24] Kranjc M, Bajd F, Sersa I, Miklavcic D. Magnetic resonance electrical impedance tomography for measuring electrical conductivity during electroporation. Physiol Meas. 2014;35(6):985-96.
• [25] Sano MB, Neal RE, Garcia PA, et al. Towards the creation of decellularized organ constructs using irreversible electroporation and active mechanical perfusion. Biomedical Engineering Online. 2010;9:83.
• [26] Garcia PA, Rossmeisl JH, Neal RE, et al. Intracranial nonthermal irreversible electroporation: in vivo analysis. The Journal of Membrane Biology. 2010;236(1):127-136.
• [27] Zupanic A, Kos B, Miklavcic D. Treatment planning of electroporation-based medical interventions: electrochemotherapy, gene electrotransfer and irreversible electroporation. Phys Med Biol. 2012;57(17):5425-40.
• [28] Groselj A, Kos B, Cemazar M, et al. Coupling treatment planning with navigation system: a new technological approach in treatment of head and neck tumors by electrochemotherapy. Biomed Eng Online. 2015;14 Suppl 3:S2.
• [29] Kos B, Voigt P, Miklavcic D, Moche M. Careful treatment planning enables safe ablation of liver tumors adjacent to major blood vessels by percutaneous irreversible electroporation (IRE). Radiol Oncol. 2015;49(3):234-41.
• [30] Edhemovic I, Gadzijev EM, Brecelj E, et al. Electrochemotherapy: a new technological approach in treatment of metastases in the liver. Technol Cancer Res Treat. 2011;10(5):475-85.
• [31] Khorasani, Firoozabadi SM, Shankayi Z. Finite Element Analysis of Tissue Conductivity during High-frequency and Low-voltage Irreversible Electroporation. Iranian Journal of Medical Physics. 2017;14(3):135-140.
• [32] Zhao Y, Bhonsle S, Dong S, et al. Characterization of conductivity changes during high-frequency irreversible electroporation for treatment planning. IEEE Transactions on Biomedical Engineering. 2018;65(8):1810-1819.
• [33] Khorasani A, Firoozabadi SM, Shankayi Z. Conductivity Changes of Liver Tissue during Irreversible Electroporation and Calculation of the Electric Field Distribution. Modares Journal of Biotechnology. 2018;9(2):227-232.
• [34] Miklavčič D, Šemrov D, Mekid H, Mir LM. A validated model of in vivo electric field distribution in tissues for electrochemotherapy and for DNA electrotransfer for gene therapy. Biochimica et Biophysica Acta. 2000;1523(1):73-83.
• [35] Garcia PA, Kos B, Rossmeisl Jr JH, et al. Predictive therapeutic planning for irreversible electroporation treatment of spontaneous malignant glioma. Medical Physics. 2017;44(9):4968-4980.
• [36] Wagstaff PG, de Bruin DM, van den Bos W, et al. Irreversible electroporation of the porcine kidney: temperature development and distribution. Urologic Oncology. 2015;33(4):168.e1-168.e7.

Uwagi

Opracowanie rekordu ze środków MNiSW, umowa Nr 461252 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2021).