Preliminary investigations of polylactide-based nanocomposites as potential materials for bone cells proliferation

• Autorzy: Frączek-Szczypta A. , Stodolak E. , Wiecheć A. , Błażewicz M.
• Języki publikacji: EN

Abstrakty

EN

Nanocomposite materials can be used in many application. In this study polymer–based nanocomposites modified with carbon nanotubes (CNTs) and ceramic silica nanoparticles (nSiO2) were used. Size and shape of nanoparticles were observed using transmission electron microscope (TEM). It was shown that, this parameter changes during mixing of nanoparticles with solvent or polymer solution. Dispersion of nanoparticles depends on their chemical composition. The CNTs are more compatible with polymer (PLDL) than nSiO2. Nanoparticles influence rheological parameters of the polymer solution (increase of viscosity). Distribution of nanoparticles within the polymer matrix was determined using DLS method. Nanocomposites in the form of thin foils were used for mechanical tests which show that small amount of nanoparticles increases tensile strength (Rm) and Young’s modulus (E) of the material. The biological properties of the polymer-based nanocomposite materials like viability and proliferation were measured using osteoblast-like human cells MG63. Results of these investigations show that both types of the nanocomposites are suitable for promoting bone tissue for faster regeneration process.

Słowa kluczowe

EN

polymer-based nanocomposite; carbon nanotube; nanosilica

• Wydawca: Polish Society for Biomaterials in Cracow
• Czasopismo: Engineering of Biomaterials
• Rocznik: 2010
• Tom: Vol. 13, no. 96-98
• Strony: 1--3
• Opis fizyczny: Bibliogr. 7 poz., rys., wykr., tab.

Twórcy

autor

Frączek-Szczypta A.

• AGH - University of Science and Technology, Faculty of Materials Science and Ceramics, Department of Biomaterials, 30 Mickiewicza Ave., 30-059 Cracow, Poland

autor

Stodolak E.

• AGH - University of Science and Technology, Faculty of Materials Science and Ceramics, Department of Biomaterials, 30 Mickiewicza Ave., 30-059 Cracow, Poland

autor

Wiecheć A.

• Polish Academy of Sciences, Institute of Nuclear Physics 152 Radzikowskiego Str., 31-342 Cracow, Poland

autor

Błażewicz M.

• AGH - University of Science and Technology, Faculty of Materials Science and Ceramics, Department of Biomaterials, 30 Mickiewicza Ave., 30-059 Cracow, Poland

Bibliografia

• [1] Zhang P, Hong Z, Yu T, Chen X, Jing X. In vivo mineralization and osteogenesis of nanocomposite scaffold of poly (lactide-coglycolide) and hydroxyapatite surface-grafted with poly(L-lactide). Biomaterials 30 (2009) 58–70.
• [2] Lei L, Li L, Zhang L, Chen D, Tian W. Structure and performance of nano-hydroxyapatite filled biodegradable poly((1,2-propanediolsebacate)- citrate) elastomers. Polymer Degradation and Stability 94 (2009) 1494–1502.
• [3] Feng J, Sui J, Cai W, Wan J, Chakoli AN, Gao Z. Preparation and characterization of magnetic multi-walled carbon nanotubes– poly(l-lactide) composite. Materials Science and Engineering B 150 (2008) 208–212.
• [4] Feng J, Yan W, Gou Z, Weng W, Yang D. Stimulating effect of silica-containing nanospheres on proliferation of osteoblast-like cells. J Mater Sci: Mater Med 18 (2007) 2167–2172.
• [5] Vallés-Lluch A, Gallego Ferrer G, Monleón Pradas M. Effect of the silica content on the physico-chemical and relaxation properties of hybrid polymer/silica nanocomposites of P(EMA-co-HEA). European Polymer Journal 46 (2010) 910–917.
• [6] Sahithi K, Swetha M, Ramasamy K, Srinivasan N, Selvamurugan N. Polymeric composites containing carbon nanotubes for bone tissue engineering. International Journal of Biological Macromolecules 46 (2010) 281–283.
• [7] Jayabalan M, Shalumon KT, Mitha MK, Ganesan K, Epple M. Effect of hydroxyapatite on the biodegradation and biomechanical stability of polyester nanocomposites for orthopaedic applications. European Polymer Journal 46 (2010) 910–917.