A comparative study of thyme ( Thymus vulgaris L.) essential oils and thymol – differences in chemical composition and cytotoxicity

• Autorzy: Fijałkowska Aurelia , Wesołowska Aneta , Rakoczy Rafał , Jedrzejczak-Silicka Magdalena

Identyfikatory

DOI

10.24425/cpe.2024.148555

• Języki publikacji: EN

Abstrakty

EN

The chemical composition of commercial thyme oils, freshly hydrodistilled EO (essetntial oil) from dried thyme herb and thymol, the main thyme oil constituent, were analyzed in the aspect of possible cytotoxic effect against MCF-7 breast cancer and normal L929 mouse fibroblast cell lines. Based on the GC-MS analysis, it was found that the commercial essential oils revealed similarities in their chemical composition. The content of main components such as thymol, linalool and α-pinene was almost equal. Interestingly, the EO obtained by hydrodistillation from Thymi herba showed considerable differences in the percentage content of some main constituents. The reason for the differences may be caused by the intraspecific chemical variability of T. vulgaris L. Four types of tested EOs can be classified as a ‘thymol’ chemotype, with thymol as the predominant compound. The thymol alone and the freshly hydrodistilled EO demonstrated the highest cytotoxic effect against used cell lines. The difference in IC50 values suggests more sensitive L929 cells are more sensitive in both the CCK-8 assay (except EOs Kawon) and the NRU assay.

Słowa kluczowe

EN

thyme; thymol; essential oil composition; cytotoxic/irritating effect; gas chromatography-mass spectrometry

PL

tymianek; tymol; olejek eteryczny; działanie cytotoksyczne; chromatografia gazowa-spektrometria mas

• Wydawca: Komitet Inżynierii Chemicznej i Procesowej Polskiej Akademii Nauk
• Czasopismo: Chemical and Process Engineering : New Frontiers
• Rocznik: 2024
• Tom: Vol. 45, nr 1
• Strony: art. no. e55
• Opis fizyczny: Bibliogr. 68 poz., tab., wykr.

Twórcy

autor

Fijałkowska Aurelia

• West Pomeranian University of Technology, Szczecin, Laboratory of Cytogenetics, Klemensa Janickiego 29, 71-270 Szczecin, Poland

autor

Wesołowska Aneta

• West Pomeranian University of Technology, Szczecin, Institute of Chemical Engineering and Environmental Protection Process, Piastow 42, 71-065 Szczecin, Poland

• https://orcid.org/0000-0001-9605-1053

autor

Rakoczy Rafał

• West Pomeranian University of Technology, Szczecin, Institute of Chemical Engineering and Environmental Protection Process, Piastow 42, 71-065 Szczecin, Poland

• https://orcid.org/0000-0002-5770-926X

autor

Jedrzejczak-Silicka Magdalena

• West Pomeranian University of Technology, Szczecin, Laboratory of Cytogenetics, Klemensa Janickiego 29, 71-270 Szczecin, Poland

• https://orcid.org/0000-0003-4818-6265

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Uwagi

Opracowanie rekordu ze środków MNiSW, umowa nr POPUL/SP/0154/2024/02 w ramach programu "Społeczna odpowiedzialność nauki II" - moduł: Popularyzacja nauki (2025)