Radiation synthesis of poly(acrylic acid) nanogels for drug delivery applications – post-synthesis product colloidal stability

Rurarz, Beata P.; Gibka, Natalia; Bukowczyk, Małgorzata; Kadłubowski, Sławomir; Ulański, Piotr

doi:10.2478/nuka-2021-0026

Artykuł - szczegóły

Tytuł artykułu

Radiation synthesis of poly(acrylic acid) nanogels for drug delivery applications – post-synthesis product colloidal stability

Autorzy

Rurarz Beata P. , Gibka Natalia , Bukowczyk Małgorzata , Kadłubowski Sławomir , Ulański Piotr

Treść / Zawartość

Pełne teksty:

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Identyfikatory

DOI

10.2478/nuka-2021-0026

Warianty tytułu

Konferencja

International Conference on Development and Applications of Nuclear Technologies NUTECH-2020 (04–07.10.2020; Warsaw, Poland)

Języki publikacji

Abstrakty

Synthesis of polymer nanogels (NGs) for biomedical applications is considered to be a very promising application in radiation engineering. Under high-dose pulse irradiation of dilute aqueous polymer solution, reactive species generated by water radiolysis can create multiple radicals on each macromolecule and consequently induce intramolecular cross-linking of polymer chains, resulting in NG formation. The obtained products are free from harmful monomers, initiators, and cross-linking agents, which makes them potentially applicable for drug delivery applications. One of the biggest challenges in handling and use of nanoparticles, however, is the colloidal stability, when aqueous suspensions are stored for prolonged periods. Therefore, development of the best protocols for the particular nanocarrier storage is key. To address this need, we have performed the prospective study in which we systematically assessed the influence of various processing and storage scenarios feasible in our lab, on the colloidal stability of the radiation-synthesized poly(acrylic acid) (PAA) NG particles in suspension. This allowed us to choose the optimal way of handling the product after its synthesis. We confirmed that none of the strategies we used and tested are substantially detrimental to our product. Filtration with 0.2-m filters was proven sufficient for sample purification and prolonged storage in aqueous suspension did not exert a negative effect on the colloidal stability of particles suspension. We have also demonstrated that lyoprotectant- -free lyophilization was suitable for our polymer nanoparticles. This is an important fact for further application of particles as nanocarriers for biologically active compounds such as targeting ligands or therapeutic moieties.

Słowa kluczowe

colloidal stability freeze-drying lyophilization nanogels poly(acrylic acid) radiation synthesis

Wydawca

Institute of Nuclear Chemistry and Technology

Czasopismo

Nukleonika

Rocznik

2021

Tom

Vol. 66, No. 4

Strony

179--186

Opis fizyczny

Bibliogr. 43 poz., rys.

Twórcy

autor

Rurarz Beata P.

beata.rurarz@dokt.p.lodz.pl

Lodz University of Technology Faculty of Chemistry Institute of Applied Radiation Chemistry Wroblewskiego 15 Str., 93-590 Lodz, Poland

https://orcid.org/0000-0001-6635-9508

autor

Gibka Natalia

Lodz University of Technology Faculty of Chemistry Institute of Applied Radiation Chemistry Wroblewskiego 15 Str., 93-590 Lodz, Poland

autor

Bukowczyk Małgorzata

Lodz University of Technology Faculty of Chemistry Institute of Applied Radiation Chemistry Wroblewskiego 15 Str., 93-590 Lodz, Poland

autor

Kadłubowski Sławomir

Lodz University of Technology Faculty of Chemistry Institute of Applied Radiation Chemistry Wroblewskiego 15 Str., 93-590 Lodz, Poland

autor

Ulański Piotr

Lodz University of Technology Faculty of Chemistry Institute of Applied Radiation Chemistry Wroblewskiego 15 Str., 93-590 Lodz, Poland

https://orcid.org/0000-0002-4310-3574

Bibliografia

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Uwagi

Opracowanie rekordu ze środków MNiSW, umowa Nr 461252 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2021).

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Bibliografia

Identyfikator YADDA

bwmeta1.element.baztech-2a8b21e3-5717-428f-84aa-8fc44c8e33b9