Determination of oroxin A, oroxin B, oroxylin A, oroxyloside, chrysin, chrysin 7-O-beta-gentiobioside, and guaijaverin in mouse blood by UPLC-MS/MS and its application to pharmacokinetics

• Autorzy: Yu Zheng , Chen Fan , Jin Yinan , Zhou Minyue , Wang Xianqin , Shen Xiuwei

Identyfikatory

DOI

10.1556/1326.2021.00963

• Języki publikacji: EN

Abstrakty

EN

In this study, a UPLC-MS/MS method was developed to measure the concentrations of the flavonoids oroxin A, oroxin B, oroxylin A, oroxyloside, chrysin, chrysin 7-O-beta-gentiobioside, and guaijaverin in the blank mouse blood, and the method was then used in the measurement of the pharmacokinetics of the compounds in mice. Oroxin A, oroxin B, oroxylin A, oroxyloside, chrysin, chrysin 7-O-beta-gentiobioside, and guaijaverin were administered intravenously at a dose of 5 mg kg⁻¹, and the mouse blood (20 μL) was withdrawn from the caudal vein 0.08333, 0.25, 0.5, 1, 2, 4, 6, 8, and 10 h after administration. The mobile phase used for chromatographic separation by gradient elution was composed of acetonitrile and water (0.1% formic acid). The analytes were detected by operating in electrospray ionization (ESI) positive-ion mode using multiple reactions monitoring (MRM). The intra-day and inter-day accuracy ranged from 86.2 to 109.3%, the intra-day precision was less than 14%, and the inter-day precision was less than 15%. The matrix effect ranged from 85.3 to 111.3%, and the recovery of the analytes after protein precipitation were all above 78.2%. This method had the advantages of high sensitivity, accuracy, and recovery, and it had excellent selectivity, which enabled it to be applied to measuring the pharmacokinetics of the analytes in mice.

Słowa kluczowe

EN

oroxin A; oroxin B; oroxylin A; oroxyloside; chrysin; mouse; pharmacokinetics

• Wydawca: University of Silesia in Katowice ; Akademiai Kiado
• Czasopismo: Acta Chromatographica
• Rocznik: 2022
• Tom: Vol. 34, no. 4
• Strony: 394--402
• Opis fizyczny: Bibliogr. 38 poz., tab., rys., wykr.

Twórcy

autor

Yu Zheng

• Analytical and Testing Centre, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China

autor

Chen Fan

• Ruian People’s Hospital, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, China

autor

Jin Yinan

• Analytical and Testing Centre, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China

autor

Zhou Minyue

• Analytical and Testing Centre, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China

autor

Wang Xianqin

• Analytical and Testing Centre, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China

autor

Shen Xiuwei

• Ruian People’s Hospital, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, China

• https://orcid.org/0000-0002-2963-423X

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Uwagi

Opracowanie rekordu ze środków MEiN, umowa nr SONP/SP/546092/2022 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2022-2023).