The derivatization and analysis of anticancer pharmaceuticals in the presence of tricyclic antidepressants by gas chromatography

• Autorzy: Haliński Ł. , Śmigiel D. , Czerwicka M. , Paszkiewicz M. , Kumirska J. , Stepnowski P.
• Języki publikacji: EN

Abstrakty

EN

The evaluation of several derivatization procedures for the gas chromatographic analysis of selected anticancer pharmaceuticals (cyclophosphamide, iphosphamide, flutamide, chlorambucil, and melphalan) in the presence of tricyclic antidepressants was carried out. Among the methods, concerning trimethylsilylation, tert-butyldimethylsilylation, and methylation, the most useful was methylation using (trimethylsilyl)diazomethane (TMSD), which is a safe alternative for the common reaction with diazomethane. Most of the anticancer drugs were unstable during derivatization using silylating agents, while antidepressants were stable in all tested conditions. Melphalan was the only compound, for which the results of all tested procedures were not satisfying. The TMSD-based procedure was validated, giving the results possibly suitable for the screening purposes in contaminated environmental samples.

Słowa kluczowe

EN

anticancer drugs; tricyclic antidepressants; water contamination; gas chromatography; derivatization

• Wydawca: University of Silesia in Katowice ; Akademiai Kiado
• Czasopismo: Acta Chromatographica
• Rocznik: 2014
• Tom: Vol. 26, no. 3
• Strony: 473--484
• Opis fizyczny: Bibliogr. 17 poz., rys., tab.

Twórcy

autor

Haliński Ł.

• University of Gdańsk Department of Environmental Analysis, Institute for Environmental and Human Health Protection, Faculty of Chemistry Wita Stwosza 63 80-952 Gdańsk Poland

autor

Śmigiel D.

• University of Gdańsk Department of Environmental Analysis, Institute for Environmental and Human Health Protection, Faculty of Chemistry Wita Stwosza 63 80-952 Gdańsk Poland

autor

Czerwicka M.

• University of Gdańsk Department of Environmental Analysis, Institute for Environmental and Human Health Protection, Faculty of Chemistry Wita Stwosza 63 80-952 Gdańsk Poland

autor

Paszkiewicz M.

• University of Gdańsk Department of Environmental Analysis, Institute for Environmental and Human Health Protection, Faculty of Chemistry Wita Stwosza 63 80-952 Gdańsk Poland

autor

Kumirska J.

• University of Gdańsk Department of Environmental Analysis, Institute for Environmental and Human Health Protection, Faculty of Chemistry Wita Stwosza 63 80-952 Gdańsk Poland

autor

Stepnowski P.

• University of Gdańsk Department of Environmental Analysis, Institute for Environmental and Human Health Protection, Faculty of Chemistry Wita Stwosza 63 80-952 Gdańsk Poland

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