Multiwavelength laser doppler holography (MLDH) in spatiotemporal optical coherence tomography (STOC-T)

• Autorzy: Borycki Dawid , Auksorius Egidijus , Węgrzyn Piotr , Liżewski Kamil , Tomczewski Slawomir , Žičkienė Ieva , Adomavičius Karolis , Karnowski Karol , Wojtkowski Maciej

Identyfikatory

DOI

10.1016/j.bbe.2024.03.002

• Języki publikacji: EN

Abstrakty

EN

Spatiotemporal optical coherence tomography (STOC-T) is the novel modality for high-speed, crosstalk- and aberration-free volumetric imaging of biological tissue in vivo. STOC-T extends the Fourier-Domain holographic Optical Coherence Tomography by the spatial phase modulation that enables the reduction of spatial coherence of the tunable laser. By reducing the spatial coherence of the laser, we suppress coherent noise, and, consequently, improve the imaging depth. Furthermore, we remove geometrical aberrations computationally in postprocessing. We recently demonstrated high-speed, high-resolution STOC-T of human retinal imaging in vivo. Here, we show that the dataset produced by STOC-T can be processed differently to reveal blood flow in the human retina in vivo. To render the blood flow, we first pre-process STOC-T holographic data to access the approximated information about the Doppler-shifted optical field backscattered from the sample. Then, we analyze it using methods from the laser Doppler flowmetry, namely, by analyzing the Doppler broadening caused by moving light scatterers (red blood cells). However, contrary to conventional approaches, we use multiple illumination wavelengths. This enables us to render the structural volumetric and blood flow images from the same dataset concurrently. Our method, denoted as multiwavelength laser Doppler holography (MLDH), links laser Doppler flowmetry with multiwavelength holographic detection to enable noninvasive visualization and possible blood flow quantification at different human retina layers at high speeds and high transverse resolution in vivo.

Słowa kluczowe

EN

optical coherence tomography; Doppler flowmetry; laser doppler holography; Fourier domain

PL

optyczna tomografia koherentna; laserowa przepływometria dopplerowska; metoda Fouriera

• Wydawca: Nałęcz Institute of Biocybernetics and Biomedical Engineering of the Polish Academy of Sciences ; Elsevier
• Czasopismo: Biocybernetics and Biomedical Engineering
• Rocznik: 2024
• Tom: Vol. 44, no. 1
• Strony: 264--275
• Opis fizyczny: Bibliogr. 63 poz., rys., tab., wykr.

Twórcy

autor

Borycki Dawid

• International Centre for Translational Eye Research, Skierniewicka 10a, Warsaw 01-230, Poland
• Institute of Physical Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, Warsaw 01-224, Poland

autor

Auksorius Egidijus

• International Centre for Translational Eye Research, Skierniewicka 10a, Warsaw 01-230, Poland
• Center for Physical Sciences and Technology (FTMC), Saulėtekio al. 3, Vilnius LT-10257, Lithuania

autor

Węgrzyn Piotr

• International Centre for Translational Eye Research, Skierniewicka 10a, Warsaw 01-230, Poland
• Faculty of Physics, University of Warsaw, Pasteura 5, Warsaw 02-093, Poland

autor

Liżewski Kamil

• International Centre for Translational Eye Research, Skierniewicka 10a, Warsaw 01-230, Poland
• Institute of Physical Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, Warsaw 01-224, Poland

autor

Tomczewski Slawomir

• International Centre for Translational Eye Research, Skierniewicka 10a, Warsaw 01-230, Poland
• Institute of Physical Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, Warsaw 01-224, Poland

autor

Žičkienė Ieva

• Center for Physical Sciences and Technology (FTMC), Saulėtekio al. 3, Vilnius LT-10257, Lithuania

autor

Adomavičius Karolis

• Center for Physical Sciences and Technology (FTMC), Saulėtekio al. 3, Vilnius LT-10257, Lithuania

autor

Karnowski Karol

• International Centre for Translational Eye Research, Skierniewicka 10a, Warsaw 01-230, Poland
• Institute of Physical Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, Warsaw 01-224, Poland

autor

Wojtkowski Maciej

• International Centre for Translational Eye Research, Skierniewicka 10a, Warsaw 01-230, Poland
• Institute of Physical Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, Warsaw 01-224, Poland

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Uwagi

PL

Opracowanie rekordu ze środków MNiSW, umowa nr SONP/SP/546092/2022 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2024).