Investigations of mass transfer in simulated biomedical systems

• Autorzy: Adach-Maciejewska Anna , Kopka Klaudia

Identyfikatory

DOI

10.24425/cpe.2023.147405

• Konferencja: 24th Polish Conference of Chemical and Process Engineering, 13-16 June 2023, Szczecin, Poland. Guest editor: Prof. Rafał Rakoczy
• Języki publikacji: EN

Abstrakty

EN

The work motivation was to investigate in vitro system simulating drug release from Drug Eluting Stent (DES). The experiments were conducted in a custom designed unit simulating drug release from polymer covering DES in a simplified way. The active substance diffuses from a thin, internal annular layer of hydrogel (imitating “stent”) to the outer cylindrical layer of hydrogel (“artery wall”) and is at once drifted away by coaxially flowing solution (“blood”). The conducted research proved functionality of the experimental unit. The rate of mass transfer depends considerably on the mass driving force and on the affinity of substance-hydrogel. The volumetric flow rate and liquid viscosity did not affect the process significantly. The effective diffusion coefficient was calculated as a process parameter and then used in the other variants. Diffusion in hydrogel is the mechanism limiting the mass transfer in the examined system. For the first attempt, the diffusive model used in literature was employed. The provided calculations are consistent with experimental data and therefore show that despite its simplifications the model allows to estimate the amount of released substance. In conclusion, the relative substance mass, changing over time, was estimated in the respective parts of the unit. The prospect of determining the relative mass of the substance appearing in the subsequent parts of the system over time provides the opportunity to adjust the respective process parameters, which will facilitate control over the rate of mass release.

Słowa kluczowe

EN

diffusion; biomedical system; stent; modelling; mass transfer

PL

dyfuzja; system biomedyczny; stent; modelowanie; transfer masy

• Wydawca: Komitet Inżynierii Chemicznej i Procesowej Polskiej Akademii Nauk
• Czasopismo: Chemical and Process Engineering : New Frontiers
• Rocznik: 2023
• Tom: Vol. 44, nr 4
• Strony: art. no. e46
• Opis fizyczny: Bibliogr. 26 poz., rys.

Twórcy

autor

Adach-Maciejewska Anna

• Warsaw University of Technology, Faculty of Chemical and Process Engineering, Waryńskiego 1, 00-645 Warsaw, Poland

• https://orcid.org/0000-0003-2277-8094

autor

Kopka Klaudia

• Warsaw University of Technology, Faculty of Chemical and Process Engineering, Waryńskiego 1, 00-645 Warsaw, Poland

Bibliografia

• 1. Crank J., 1975. The mathematics of diffusion. 2nd edition, Oxford University Press, London, Oxford, New York.
• 2. Crank J., McFarlane N.R., Newby J.C., Paterson G.D., Pedley J.B., 1981. Diffusion processes in environmental systems. Red Globe Press London. DOI: 10.1007/978-1-349-05825-9.
• 3. Guo Q., Knight P.T., Mather P.T., 2009. Tailored drug release from biodegradable stent coatings based of hybrid polyurethanes. J. Controlled Release, 137, 224–233. DOI: 10.1016/j.jconrel.2009.04.016.
• 4. Ilnicka M., Wawrzyněska M., Biały D., 2009. Biodegradable coronary stents – overview. Acta Bio-Optica et Informatica Medica., 15, 369–372.
• 5. Kamberi M., Nayak S., Myo-Min K., Carter T.P., Hancock L.,Feder, D., 2009. A novel accelerated in vitro release method for biodegradable coating of drug eluting stents: Insight to the drug release mechanisms. Eur. J. Pharm. Sci., 37, 217–222. DOI:10.1016/j.ejps.2009.02.009.
• 6. Khan W., Farah S., Nyska A., Domb A., 2013. Carrier free rapamycin loaded drug eluting stent: In vitro and in vivo evaluation. J. Controlled Release, 168, 70–76. DOI: 10.1016/ j.jconrel.2013.02.012.
• 7. Kopka K., 2023. Badanie wpływu parametrów procesu na szybkość transportu substancji w symulowanym układzie biomedycznym. MSc Thesis, Warsaw University of Technology, Warsaw.
• 8. Makowski G., 2023. Badanie współczynników dyfuzji w układach biomedycznych. BSc Thesis, Warsaw University of Technology, Warsaw.
• 9. Mani G., Feldman, M.D., Patel D., Agrawal C.M., 2007. Coronary stents: A materials perspective. Biomaterials, 28, 1689–1710. DOI: 10.1016/j.biomaterials.2006.11.042.
• 10. Mullarney M.P., Seery T.A.P., Weiss R.A., 2006. Drug diffusionin hydrophobically modified N; N-dimethylacrylamide hydrogels. Polymer, 47, 3845–3855. DOI: 10.1016/j.polymer. 2006.03.096.
• 11. Neubert A., Sternberg K., Nagel S., Harder C., Schmitz K.-P., Kroemer H.K., Weitschies W., 2008. Development of a vessel-simulating flow-through cell method for the in vitro evaluation of release and distribution from drug-eluting stents. J. Controlled Release, 130, 2–8. DOI: 10.1016/j.jconrel.2008.05.012.
• 12. O’Brien C.C., Kolachalama V.B., Barber T.J., Simmons A., Edelman E.R., 2013. Impact of flow pulsatility on arterial drug distribution in stent-based therapy. J. Controlled Release, 168, 115–124. DOI: 10.1016/j.jconrel.2013.03.014.
• 13. O’Brien C.C., Finch C.H., Martens P., Barber T.J., Simmons A., 2011. Development of an in vitro method for modeling drug release and subsequent tissue drug uptake and deposition in a pulsatile flow network. 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Boston,
• 14. Massachusetts, USA, 30 August – 3 September 2011, 3262-3265. DOI: 10.1109/iembs.2011.6090886.
• 15. Pietrasik A., Rdzanek A., 2017. Restenoza po zabiegach przezskórnej angioplastyki wieńcowej – przyczyny, rozpoznawania, postępowanie. Choroby Serca i Naczyń, 14 (6), 352–356.
• 16. Saltzman W.M., 2001. Drug delivery. Engineering principles for drug therapy. 1st edition, Oxford University Press, Oxford.
• 17. Seidlitz A., Nagel S., Semmling B., Grabow N., Martin H., Senz V., Harder C., Sternberg K., Schmitz K-P., Kroemer H.K., Weitschies W., 2011. Examination of drug release and dis-tribution from drug-eluting stents with a vessel-simulating flow-through cell. Eur. J. Pharm. Biopharm., 78, 36–48. DOI: 10.1016/j.ejpb.2010.12.021.
• 18. Seidlitz A., Schick W., Reske T., Senz V., Grabow N., Petersen S., Nagel S., Weitschies W., 2015. In vitro study of sirolimus release from a drug-eluting stent: Comparison of the release profiles obtained using different test setups. Eur. J. Pharm. Biopharm., 93, 328–338. DOI: 10.1016/j.ejpb.2015.04.016.
• 19. Semmling B., Nagel S., Sternberg K., Weitschies W., Seidlitz A., 2014. Impact of different tissue-simulatng hydrogel compartments on in vitro release and distribution from drug- eluting stents. Eur. J. Pharm. Biopharm., 87, 570–578. DOI: 10.1016/j.ejpb.2014.04.010.
• 20. Seo T., Lafont A., Choi S.-Y., Barakat A., 2016. Drug-eluting stent design is a determinant of drug concentration at the endothelial cell surface. Ann. Biomed. Eng., 44, 302–314. DOI: 10.1007/s10439-015-1531-0.
• 21. Siepmann J., Peppas N.A., 2001. Modeling of drug release from delivery systems based on hydroxypropyl methylcellulose (HPMC). Adv. Drug Delivery Rev., 48, 139–157. DOI:10.1016/S0169-409X(01)00112-0.
• 22. Siepmann J., Peppas N.A., 2012. Modeling of drug release from delivery systems based on hydroxypropyl methylcellulose (HPMC). Adv. Drug Delivery Rev., 64, Suppl., 163–174. DOI: 10.1016/j.addr.2012.09.028.
• 23. Turula M., 2023. Modelowanie układu symulującego transport substancji aktywnej z naczynia krwionośnego do krwi. BSc Thesis, Warsaw University of Technology, Warsaw.
• 24. Vijayaratnam P.R.S., Reizes J.A., Barber T.J., 2018. Flow-mediated drug transport from drug-eluting stents is negligible: Numerical and in-vitro investigations. Ann. Biomed. Eng., 47, 878–890. DOI: 10.1007/s10439-018-02176-y.
• 25. Weber M., 2019. Badanie szybkości transportu substancji aktywnych w symulowanych układach biomedycznych dla różnych parametrów prowadzenia procesu. BSc Thesis, Warsaw University of Technology, Warsaw.
• 26. Weber M., 2020. Badanie wpływu geometrii układu na szybkosěcě transportu substancji w symulowanych układach biomedycznych. MSc Thesis, Warsaw University of Technology, Warsaw.

Uwagi

Opracowanie rekordu ze środków MNiSW, umowa nr POPUL/SP/0154/2024/02 w ramach programu "Społeczna odpowiedzialność nauki II" - moduł: Popularyzacja nauki (2025)