A vision to increase the availability of PET diagnostics in low- and medium-income countries by combining a low-cost modular J-PET tomograph with the 44Ti/44Sc generator

Moskal, Paweł; Stępień, Ewa; Khreptak, Aleksander

doi:10.5604/01.3001.0054.9273

Artykuł - szczegóły

Tytuł artykułu

A vision to increase the availability of PET diagnostics in low- and medium-income countries by combining a low-cost modular J-PET tomograph with the 44Ti/44Sc generator

Autorzy

Moskal Paweł , Stępień Ewa , Khreptak Aleksander

Wybrane pełne teksty z tego czasopisma

Identyfikatory

DOI

10.5604/01.3001.0054.9273

Warianty tytułu

Języki publikacji

Abstrakty

Objectives: This paper presents the prospects for increasing the availability of PET diagnostics by combining low-cost, lightweight and easily portable modular J-PET with the 44Ti/44Sc generator. Methods: J-PET is constructed based on the low-cost axially arranged plastic scintillators that may enable the construction of PET scanners 5 to 10 times less expensive compared to current PET systems, which are based on crystal scintillators. Development of the radionuclide 44Ti/44Sc generator with the 60-year half-lifetime would enable long-term onsite production of 44Sc labelled radiopharmaceuticals, eliminating the need for extensive and costly infrastructure typically associated with nuclear medicine. Presently applied 68Ge/68Ga generators with the 270 days half- -lifetime require renewal every year. The 44Ti/44Sc generator could, in principle, be purchased once every half century. Results: The lightweight and portable J-PET scanner, combined with the 44Ti/44Sc generator, can be deployed in remote and underserved regions, thus democratising access to advanced medical-imaging techniques. Conclusions: This novel concept shows the transformative potential of combining innovative J-PET technology with the 44Ti/44Sc generator to make advanced diagnostics more accessible and affordable worldwide, especially benefiting millions of patients in low- and medium-income countries, and driving further innovations in medical imaging.

Słowa kluczowe

positron emission tomography PET modular J-PET scandium 44Ti/44Sc generator

Wydawca

Uniwersytet Jagielloński - Collegium Medicum
Index Copernicus Sp. z o.o.

Czasopismo

Bio-Algorithms and Med-Systems

Rocznik

2024

Tom

Vol. 20, Special issue

Strony

55--62

Opis fizyczny

Bibliogr. 64 poz., rys.

Twórcy

autor

Moskal Paweł

p.moskal@uj.edu.pl

Marian Smoluchowski Institute of Physics, Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University; Łojasiewicza 11, 30-348, Krakow, Poland
Total-Body Jagiellonian-PET Laboratory, Jagiellonian University, Kraków, Poland
Center for Theranostics, Jagiellonian University, Kraków, Poland

https://orcid.org/0000-0002-4229-3548

autor

Stępień Ewa

Marian Smoluchowski Institute of Physics, Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, Kraków, Poland
Total-Body Jagiellonian-PET Laboratory, Jagiellonian University, Kraków, Poland
Center for Theranostics, Jagiellonian University, Kraków, Poland

https://orcid.org/0000-0003-3589-1715

autor

Khreptak Aleksander

Marian Smoluchowski Institute of Physics, Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, Kraków, Poland
Total-Body Jagiellonian-PET Laboratory, Jagiellonian University, Kraków, Poland
Center for Theranostics, Jagiellonian University, Kraków, Poland

https://orcid.org/0000-0002-9482-9770

Bibliografia

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