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Abstrakty
Citrus reticulata cv. Chachiensis, a traditional Chinese herb, has extensive medicinal and edible effects. 3′,4′,5,6,7,8-Hexamethoxyflavone (HM) and 5,6,7,8,4′-pentamethoxyflavone (PM) are main bioactive compounds in Chachiensis, which have been reported to possess various biological properties. In this study, supercritical CO2 extraction (SCE) and high-speed countercurrent chromatography (HSCCC) were utilized to prepare HM and PM from Chachiensis. The contents of target compounds were determined by a high-performance liquid chromatography method with diode-array detection (HPLC-DAD), which was validated using the following parameters: linearity, sensitivity, repeatability, stability, precision and accuracy. The SCE conditions were optimized using response surface methodology with central composite design. Obtained optimum conditions were temperature of 37.9 °C, pressure of 26.3 MPa, and modifier volume of 81.0 mL. Under above conditions, the recoveries of target compounds were 92.52 ± 0.83 and 96.36 ± 0.43%, respectively. The most appropriate solvent system for HSCCC was selected as n-hexane/ethyl acetate/methanol/water (1:0.8:1:1.2, v/v). The HSCCC fractions were detected by HPLC-DAD, liquid chromatography-mass spectrometry (LC-MS) and nuclear magnetic resonance spectroscopy (1H NMR and 13C NMR). The results indicated that this method was successfully applied to obtain HM and PM with high purities and high recoveries from Chachiensis.
Słowa kluczowe
Czasopismo
Rocznik
Tom
Strony
270--280
Opis fizyczny
Bibliogr. 34 poz., rys., tab.
Twórcy
autor
- School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China
autor
- School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China
autor
- School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China
- Guangdong Technology Research Center for Advanced Chinese Medicine, Guangzhou, 510006, China
autor
- School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, 511436, China
autor
- School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China
- Guangdong Technology Research Center for Advanced Chinese Medicine, Guangzhou, 510006, China
autor
- School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China
- Guangdong Technology Research Center for Advanced Chinese Medicine, Guangzhou, 510006, China
Bibliografia
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- 7. Gao, Z.; Wang, Z. Y.; Guo, Y.; Chu, C.; Zheng, G. D.; Liu, E. H.; Li, F. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2019, 1124, 226–32.
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Typ dokumentu
Bibliografia
Identyfikator YADDA
bwmeta1.element.baztech-26cb5bbf-505c-4654-bb5a-b2e66f26b8da