Development of quantitative HPTLC–Densitometry methods for the analysis of amiodarone HCl, carvedilol, doxylamine succinate, magnesium salicylate, metoprolol succinate, nebivolol HCl, and salicylamide using a model process developed earlier for the transfer of TLC screening methods

• Autorzy: Nguyen K. , Sherma J.

Identyfikatory

DOI

10.1556/1326.2017.00367

• Języki publikacji: EN

Abstrakty

EN

A model process, previously developed in a series of studies, allows for the transfer of thin-layer chromatography (TLC) methods for qualitative screening of counterfeit drug products published in the Global Pharma Health Fund (GPHF) Minilab manual and US Food and Drug Administration (FDA) Compendium of Unofficial Methods for Screening of Pharmaceuticals by TLC to quantitative high-performance TLC (HPTLC)–densitometry methods. This article describes HPTLC–densitometry methods developed and validated according to this model process for pharmaceutical products of amiodarone HCl, carvedilol, doxylamine succinate, magnesium salicylate, metoprolol succinate, nebivolol HCl, and salicylamide, for which qualitative screening methods have not been published in the Minilab manual or FDA Compendium. These methods use relatively inexpensive and nontoxic “green solvents” for sample and standard solution and mobile phase preparation, Merck Premium Purity silica gel 60 F₂₅₄ plates, automated standard and sample solution bandwise application, and automated densitometry for the assessment of peak purity and identity and quantification. Corresponding to the quantitative HPTLC–densitometry methods, qualitative TLC screening methods for these drug products were developed and posted online with open access as supplements to the FDA Compendium.

Słowa kluczowe

EN

Amiodarone HCl; carvedilol; doxylamine succinate; magnesium salicylate; metoprolol succinate; nebivolol HCl; salicylamides; thin-layer chromatography; densitometry; drug analysis

• Wydawca: University of Silesia in Katowice ; Akademiai Kiado
• Czasopismo: Acta Chromatographica
• Rocznik: 2018
• Tom: Vol. 30, no. 4
• Strony: 264--268
• Opis fizyczny: Bibliogr. 26 poz., rys.

Twórcy

autor

Nguyen K.

• Department of Chemistry, Lafayette College, Easton, PA, USA

autor

Sherma J.

• Department of Chemistry, Lafayette College, Easton, PA, USA

Bibliografia

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• [5] Kenyon A. S.; Layloff T. P. A Compendium of Unofficial Methods for Rapid Screening of Pharmaceutical by Thin Layer Chromatography http://www.layloff.net Google Scholar
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Uwagi

PL

Opracowanie rekordu w ramach umowy 509/P-DUN/2018 ze środków MNiSW przeznaczonych na działalność upowszechniającą naukę (2018).