Microwave assisted synthesis, spectral studies and antimicrobial activities of some 2′,4′-difluorophenyl chalcones

• Autorzy: Vijayakumar S. , Arulkumaran R. , Sundararajan R. , Sakthinathan S. P. , Suresh R. , Kamalakkannan D. , Ranganathan K. , Sathiyamoorthy K. , Mala V. , Vanangamudi G. , Thirunarayanan G.
• Języki publikacji: EN

Abstrakty

EN

Some 2′,4′-difluorophenyl chalcones have been synthesized under microwave irradiation using aldol condensation between 2,4-difluoroacetophenone and substituted benzaldehydes using catalytic amount of hydroxyapatite. The yields of the chalcones are more than 85 %. The purities of these synthesized chalcones were examined by their physical constants and spectroscopic data. The UV absorption maxima (λmax, nm), infrared stretches (ν, cm-1) of CO, fingerprint region of CHip/op, CH=CHop, C=Cop modes, NMR chemical shifts (δ, ppm) of vinyl proton, carbon and carbonyl carbons have been assigned and correlated with Hammett substituent constants, F and R parameters using single and multi-regression analysis. From the statistical analysis the effect of substituent on the above spectral frequencies can be discussed. The antimicrobial activities of these synthesized chalcones have been screened using Bauer-Kirby method.

Słowa kluczowe

EN

Microwave irradiation; Aldol condensation; Hydroxyapatite; Spectral correlations; Hammett σ constants; antimicrobial activities

• Wydawca: Przedsiębiorstwo Wydawnictw Naukowych "DARWIN"
• Czasopismo: International Letters of Chemistry, Physics and Astronomy
• Rocznik: 2013
• Tom: Vol. 9, iss. 1
• Strony: 68--86
• Opis fizyczny: Bibliogr. 37 poz., rys., tab.

Twórcy

autor

Vijayakumar S.

• PG and Research Department of Chemistry, Government Arts College, C-Mutlur, Chidambaram - 608102, India

autor

Arulkumaran R.

• PG and Research Department of Chemistry, Government Arts College, C-Mutlur, Chidambaram - 608102, India

autor

Sundararajan R.

• PG and Research Department of Chemistry, Government Arts College, C-Mutlur, Chidambaram - 608102, India

autor

Sakthinathan S. P.

• PG and Research Department of Chemistry, Government Arts College, C-Mutlur, Chidambaram - 608102, India

autor

Suresh R.

• PG and Research Department of Chemistry, Government Arts College, C-Mutlur, Chidambaram - 608102, India

autor

Kamalakkannan D.

• PG and Research Department of Chemistry, Government Arts College, C-Mutlur, Chidambaram - 608102, India

autor

Ranganathan K.

• PG and Research Department of Chemistry, Government Arts College, C-Mutlur, Chidambaram - 608102, India

autor

Sathiyamoorthy K.

• PG and Research Department of Chemistry, Government Arts College, C-Mutlur, Chidambaram - 608102, India

autor

Mala V.

• PG and Research Department of Chemistry, Government Arts College, C-Mutlur, Chidambaram - 608102, India

autor

Vanangamudi G.

• PG and Research Department of Chemistry, Government Arts College, C-Mutlur, Chidambaram - 608102, India
• [e-mail]

autor

Thirunarayanan G.

• Department of Chemistry, Annamalai University, Annamalainagar - 608002, Inida

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