A simple HPLC method for the determination of butorphanol tartrate and ondansetron hydrochloride in patient-controlled analgesia solution

• Autorzy: Fang B. , Wang L. , Chen F. , Li P. , Shi X.

Identyfikatory

DOI

10.1556/1326.2016.00142

• Języki publikacji: EN

Abstrakty

EN

A simple and rapid high-performance liquid chromatographic (HPLC) method was established for simultaneous determination of butorphanol tartrate and ondansetron hydrochloride in analgesic mixture samples used for patient-controlled analgesia (PCA). The separation of butorphanol tartrate and ondansetron hydrochloride in PCA solution was carried out on phenomenex C18 column (4.6 mm × 150 mm, 5 μm) using 50 mM sodium acetate (pH 4.0) buffer and acetonitrile (72:28, v/v). Flow rate was 1.0 mL min−1 with a column temperature of 30 °C, and detection wavelength was carried out at 280 nm and 306 nm. Validation of the method was made in terms of specificity, linearity, accuracy, and intra- and inter-day precision, as well as quantification and detection limits. The developed method was successfully used to evaluate the chemical stability of butorphanol tartrate and ondansetron hydrochloride in analgesic mixtures at the usual concentration used for PCA.

Słowa kluczowe

EN

Butorphanol; ondansetron; HPLC; simultaneous determination; stability; patient-controlled analgesia

• Wydawca: University of Silesia in Katowice ; Akademiai Kiado
• Czasopismo: Acta Chromatographica
• Rocznik: 2018
• Tom: Vol. 30, no. 1
• Strony: 43--46
• Opis fizyczny: Bibliogr. 15 poz., rys., tab.

Twórcy

autor

Fang B.

• Department of Pharmacy, Dongfeng Hospital, Hubei University of Medicine, Shiyan, Hubei, 442008, P.R. China

autor

Wang L.

• Department of Pharmacy, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei, 442000, P.R. China

autor

Chen F.

• Department of Pharmacy, Dongfeng Hospital, Hubei University of Medicine, Shiyan, Hubei, 442008, P.R. China

autor

Li P.

• Department of Pharmacy, Dongfeng Hospital, Hubei University of Medicine, Shiyan, Hubei, 442008, P.R. China

autor

Shi X.

• Department of Pharmacy, Dongfeng Hospital, Hubei University of Medicine, Shiyan, Hubei, 442008, P.R. China

Bibliografia

• [1] Wang, F. Z. ; Shen, X. F. ; Liu, Y. S. ; Eur. J. Anaesthesiol. 2009 , 26 , 28 – 34.
• [2] Thakore, B. ; D'Mello, J. ; Saksena, S. ; Acute Pain 2009 , 11 , 93 – 99.
• [3] Wu, S. J. ; Xiong, X. Z. ; Lin, Y. X. ; Surg. Laparosc. Endosc. Percutan. Tech. 2013 , 23 , 79 – 87.
• [4] Schwartzberg, L. ; Barbour, S. Y. ; Morrow, G. R. ; Support Care Cancer 2014 , 22 , 469 – 477.
• [5] Zeng, X. Y. ; Liu, J. Z. ; Li, G. Q. Med J Liaoning 2010 , 24 , 119 – 122.
• [6] Chen, F. C. ; Fang, B. X. ; Li, P. ; Am. J. Health Syst. Pharm. 2013 , 70 , 515 – 519.
• [7] Chen, F. C. ; Xiong, H. ; Liu, H. M. ; Am. J. Health Syst. Pharm. 2015 , 72 , 1374 – 1378.
• [8] Shirish, R. P. ; Patel, L. J. ; Yogeshvar, P. T. ; Nimesh, D. P. Int. J. Chemtech. Res. 2010 , 2 , 1531 – 1536.
• [9] Dedania, Z. ; Dedania, R. ; Karkhanis, V. ; Asian J. Res. Chem. 2009 , 2 , 108 – 111.
• [10] Suneetha A. ; Chandana, P. T. J. Pharm. Res. 2014 , 13 , 106 – 110.
• [11] Amarnath, B. M. ; Srinivas, M. Int. J. Pharmtech. Res. 2014 , 6 , 1794 – 1802.
• [12] Chen, F. C. ; Shi, X. Y. ; Li, P. ; Medicine 2015 , 94 , e432.
• [13] Meyyanathan, S. N. ; Venkatesh, D. N. ; Krishnaveni, N. ; Int. J. Health Allied Sci. 2012 , 1 , 129.
• [14] Venkateshwaran, T. G. ; King, D. T. ; Stewart, J. T. J. Liq. Chromatogr. Relat. Technol. 1995 , 18 , 117 – 126.
• [15] King, D. T. ; Stewart, J. T. J. Liq. Chromatogr. Relat. Technol. 1993 , 16 , 2309 – 2323.

Uwagi

PL

Opracowanie rekordu w ramach umowy 509/P-DUN/2018 ze środków MNiSW przeznaczonych na działalność upowszechniającą naukę (2018).