Recycling preparative high performance liquid chromatography for the separation of curcumin from curcuminoids in curcuma longa L.

• Autorzy: Mollayi S. , Tamhidi S. , Hashempour H. , Ghassempour A.
• Języki publikacji: EN

Abstrakty

EN

Curcumin is the main bioactive constituent of turmeric rhizome. A wide range of pharmacological activities of curcumin has been reported. There has been growing interest in the development of preparative purification of curcumin. The objective of this study is the isolation of curcumin from other components by using recycling preparative HPLC method from curcuma longa L. The extraction was achieved by using ultrasonic system with three different solvents, including acetone, dichloromethane, and ethanol. After optimization of extraction process, preparative HPLC system was first applied for separation of curcumin. Because of poor resolution of preparative HPLC, recycled preparative HPLC was applied for separation of curcumin with higher purity up to five cycles. Recycled preparative HPLC resulted in improvement in separation factors which led to the increase of curcumin purity up to 99.5%. This method is simple, highly efficient, environmentally friendly, and has been demonstrated to be effective for preparation and purification of curcumin from curcuma longa L.

Słowa kluczowe

EN

Curcuma longa L.; curcumin; preparative HPLC; recycling preparative HPLC

• Wydawca: University of Silesia in Katowice ; Akademiai Kiado
• Czasopismo: Acta Chromatographica
• Rocznik: 2015
• Tom: Vol. 27, no. 2
• Strony: 387--398
• Opis fizyczny: Bibliogr. 29 poz., rys., tab.

Twórcy

autor

Mollayi S.

• Shahid Beheshti University, G. C. Evin Medicinal Plants and Drugs Research Institute Tehran Iran

autor

Tamhidi S.

• Amirkabir University of Technology Department of Chemistry Tehran Iran

autor

Hashempour H.

• Azarbaijan Shahid Madani University Phytochemistry Group, Department of Chemistry, Faculty of Science Tabriz Iran

autor

Ghassempour A.

• Shahid Beheshti University, G. C. Evin Medicinal Plants and Drugs Research Institute Tehran Iran

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