Osteointegration technology in long bone defect reconstruction: experimental study

• Autorzy: Popkov Arnold , Kononovich Natalia , Gorbach Elena , Popkov Dmitry

Identyfikatory

DOI

10.37190/ABB-01664-2020-04

• Języki publikacji: EN

Abstrakty

EN

The purpose of this experimental study was to evaluate the osteointegration of a bioactive 3D-cylindrical titanium-alloy implant (bone-graft substitute) for tibial shaft defect reconstruction. Methods: An experimental study was done in 7 mongrel dogs. Tibial shaft defect was repaired using an original titanium-alloy (Ti6Al4V) cellular cylindrical implant. with a bioactive layer of hydroxyapatite by anode microarc oxidation. Histological study (hematoxylin-eosin stain and immunohistological reaction using ostepontin polyclonal antibodies) and scanning electron microscopy (electron probe X-ray microanalysis for calcium and phosphorus saturation in the tissue matrix) were applied to assess bone tissue regeneration. Results: Experimental study revealed osteoconduction starting from the endosteum of bone fragments adjacent to the bone defect and developed to the central part of the implant. In 4 weeks, graft osteointegration was achieved in all animals. Implant cells were filled with spongy bone tissue and the graft external surface was covered with a connective tissue structures similar to the periosteum ones. Conclusions: Cellular titanium bone-graft substitute with bioactive coatings placed into bone defect stimulates reparative osteogenesis and graft osteointegration.

Słowa kluczowe

EN

bone-graft substitute; hydroxyapatite coating; osteointegration

PL

substytut przeszczepu kości; powłoka hydroksyapatytowa; osteointegracja

• Wydawca: Oficyna Wydawnicza Politechniki Wrocławskiej
• Czasopismo: Acta of Bioengineering and Biomechanics
• Rocznik: 2020
• Tom: Vol. 22, no. 4
• Strony: 85--91
• Opis fizyczny: Bibliogr. 25 poz., fot., rys., tab.

Twórcy

autor

Popkov Arnold

• Ilizarov National Medical Research Center for Traumatology and Orthopedics, Kurgan, Russia

autor

Kononovich Natalia

• Ilizarov National Medical Research Center for Traumatology and Orthopedics, Kurgan, Russia

autor

Gorbach Elena

• Ilizarov National Medical Research Center for Traumatology and Orthopedics, Kurgan, Russia

autor

Popkov Dmitry

• Ilizarov National Medical Research Center for Traumatology and Orthopedics, Kurgan, Russia

Bibliografia

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