Reakcja Niementowskiego

• Autorzy: Łysakowska M. , Piotrowska D. G.

Warianty tytułu

EN

The Niementowski reaction

• Języki publikacji: PL

Abstrakty

EN

The Niementowski reaction depends on the fusion of anthranilic acid with carbonyl compounds or amides and dates back to the end of the nineteenth century. Numerous variations of the reaction components and modifications of the reaction conditions have appeared in the literature through years. Besides anthranilic acid other synthons including: methyl o-aminobenzoate [25], o-nitrobenzoic acid [26], o-acylaminobenzamide [21], o-aminobenzamide [27], o-aminobenzonitrile [28], isatoic anhydride [29], benzoxasinone [30, 31] have been employed as well. Replacement of the amide component with either amine [9, 32], nitrile [33], imidate [34], thioamide [35], amidine [36], aldehyde [37] or carboxylic acid [28] have also been reported. To increase yield and to reduce the reaction time a number of variables in reaction conditions have been investigated. The best results have been achieved by implementation of a microwave irradiation [38]. The Niementowski reaction and its variants have found widespread use in pharmaceutical and agrochemical fields for the synthesis of compounds containing quinoline and quinazoline systems which are present in a number of natural and synthetic alkaloids [12, 13] and many drugs [1–5].

Słowa kluczowe

PL

reakcja Niementowskiego; chinolina; chinazolina; chinazolin-4-on; kwas antranilowy

EN

Niementowski reaction; quinoline; quinazoline; quinazolin-4-one; anthranilic acid

• Wydawca: Polskie Towarzystwo Chemiczne
• Czasopismo: Wiadomości Chemiczne
• Rocznik: 2015
• Tom: [Z] 69, 5-6
• Strony: 369--390
• Opis fizyczny: Bibliogr. 59 poz., schem.

Twórcy

autor

Łysakowska M.

• Zakład Chemii Bioorganicznej, Wydział Farmaceutyczny, Uniwersytet Medyczny w Łodzi, ul. Muszyńskiego 1, 90-151 Łódź

autor

Piotrowska D. G.

• Zakład Chemii Bioorganicznej, Wydział Farmaceutyczny, Uniwersytet Medyczny w Łodzi, ul. Muszyńskiego 1, 90-151 Łódź

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