Observer design estimating the propofol concentration in PKPD model with feedback control of anesthesia administration

• Autorzy: Ilyas Muhammad , Khan Awais , Khan Muhammad Abbas , Xie Wei , Riaz Raja Ali , Khan Yousaf

Identyfikatory

DOI

10.24425/acs.2022.140866

• Języki publikacji: EN

Abstrakty

EN

Propofol infusion in anesthesia administration requires continual adjustment in the manual infusion system to regulate the hypnosis level. Hypnotic level is based on Bispectral Index Monitor (BIS) showing the cortical activity of the brain scaled between 0 to 100. The new challenging aspect of automation in anaesthesia is to estimate the concentration of hypnotic drugs in different compartments of the body including primary, rapid peripheral (muscle), slow peripheral (bones, fat) and effect site (brain) compartment based on Pharmacokinetics (PK) and Pharmacodynamics (PD) model. This paper aimed to regulate the hypnosis level with estimating the Propofol concentrations using a linear observer in feedback control strategy based on Integral Super-Twisting Sliding Mode Controller (ISTSMC). The drug concentration in plasma of the silico patients accurately estimated in nominal transient. The results show that tracking errors between the actual output in form of BIS level and linearized output nearly approaches to zero in the maintenance phase of anesthesia to ensure the controller response on sliding phase with optimum performances by achieving desired hypnotic level 50 on BIS. The robustness of control strategy is further ensured by adding measurement noise of electromagnetic environment of operation theatre distracting signal quality index of the output BIS level.

Słowa kluczowe

EN

pharmacokinetic models; pharmacodynamic model; bispectral index monitor; observer design; sliding mode control

• Wydawca: Polish Academy of Sciences, Committee of Automatic Control and Robotics
• Czasopismo: Archives of Control Sciences
• Rocznik: 2022
• Tom: Vol. 32, No. 1
• Strony: 85--103
• Opis fizyczny: Bibliogr. 30 poz., fot., rys., tab., wzory

Twórcy

autor

Ilyas Muhammad

• Department of Electrical Engineering, Balochistan University of Engineering and Technology Khuzdar, Pakistan

autor

Khan Awais

• College of Mechatronics and Control Engineering and Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, Shenzhen University, Shenzhen 518060, China

autor

Khan Muhammad Abbas

• Department of Electrical Engineering, Balochistan University of Information Technology, Engineering and Management Sciences, Quetta, Pakistan

autor

Xie Wei

• College of Automation Science and Technology, South China University of Technology, Guangzhou 510641, People’s Republic of China

autor

Riaz Raja Ali

• Department of Electrical and Computer Engineering, Comsats University Islamabad 45550, Pakistan

autor

Khan Yousaf

• Department of Electrical Engineering, Univeristy of Engineering and Technology Peshawar, Peshawar, Pakistan

Bibliografia

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Uwagi

1. This work was supported in part by Key-Area Research and Development Program of Foshan City under Grant 2020001006812.

2. Opracowanie rekordu ze środków MEiN, umowa nr SONP/SP/546092/2022 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2022-2023)