Pharmacokinetics of ebeiedinone in mouse blood by UPLC–MS/MS

Jin, Yongxi; Chen, Yuyan; Liu, Jiawen; Bao, Xi; Zhi, Yinghao; Wen, Congcong; Zhu, Wenzong

doi:10.1556/1326.2019.00680

Artykuł - szczegóły

Tytuł artykułu

Pharmacokinetics of ebeiedinone in mouse blood by UPLC–MS/MS

Autorzy

Jin Yongxi , Chen Yuyan , Liu Jiawen , Bao Xi , Zhi Yinghao , Wen Congcong , Zhu Wenzong

Wybrane pełne teksty z tego czasopisma

Identyfikatory

DOI

10.1556/1326.2019.00680

Warianty tytułu

Języki publikacji

Abstrakty

An ultra-performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) method was established to determine ebeiedinone in mouse blood, and the pharmacokinetics of ebeiedinone after intravenous (0.5 mg/kg) and oral (2, 4, and 8 mg/kg) administration was studied. Twenty-four mice were randomly divided into 4 groups, 1 group was for intravenous administration (0.5 mg/kg), and other 3 groups were for oral administration (2, 4, and 8 mg/kg), with 6 rats in each group. Yubeinine was used as an internal standard. Multiple reaction monitoring (MRM) mode was used to quantitatively analyzed ebeiedinone m/z 414.4 → 91.1 and the internal standard m/z 430.4 → 412.3 in the electrospray ionization (ESI) positive interface. In the concentration range of 1–2000 ng/mL, the ebeiedinone in the mouse blood was linear (r2 > 0.995), and the lower limit of quantification was 1.0 ng/mL. In the mouse blood, the intra-day precision coefficient of variation (CV) was less than 15%, and the inter-day precision CV was less than 15%. The accuracy ranged from 85.4% to 114.6%, and the average recovery was higher than 61.3%. The matrix effect was between 87.0% and 106.5%. These data met the pharmacokinetic study requirements of ebeiedinone. The UPLC–MS/MS method was sensitive, rapid, and selective and was successfully applied to the pharmacokinetic study of ebeiedinone in mice. The absolute bioavailability of ebeiedinone was 30.6%.

Słowa kluczowe

Ebeiedinone pharmacokinetics mouse UPLC–MS/MS

Wydawca

University of Silesia in Katowice
Akademiai Kiado

Czasopismo

Acta Chromatographica

Rocznik

2020

Tom

Vol. 32, no. 3

Strony

194--198

Opis fizyczny

Bibliogr. 40 poz., rys.

Twórcy

autor

Jin Yongxi

Wenzhou Municipal Hospital of Traditional Chinese Medicine, Wenzhou 325005, China

autor

Chen Yuyan

Wenzhou Medical University, Wenzhou 325035, China

autor

Liu Jiawen

Wenzhou Medical University, Wenzhou 325035, China

autor

Bao Xi

The First Affiliated Hospital of Wenzhou Medical University, WenZhou 325000, China

autor

Zhi Yinghao

Wenzhou Municipal Hospital of Traditional Chinese Medicine, Wenzhou 325005, China

autor

Wen Congcong

Wenzhou Medical University, Wenzhou 325035, China

autor

Zhu Wenzong

Wenzhou Municipal Hospital of Traditional Chinese Medicine, Wenzhou 325005, China

Bibliografia

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Uwagi

Opracowanie rekordu ze środków MNiSW, umowa Nr 461252 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2020).

Typ dokumentu

Bibliografia

Identyfikator YADDA

bwmeta1.element.baztech-22539af2-7fd3-41fd-81af-58d2f0be8f87