Cell outer membrane mimetic surface as a material with improved hemocompatibility

• Autorzy: Trzaskowski M. , Butruk B. , Ciach T.
• Języki publikacji: EN

Abstrakty

EN

The phenomenon of blood coagulation on the surfaces of implantable devices such as artifi cial blood vessels, valves or hearts is the major problem that has to be taken into consideration during the construction of such devices. Since the main factor that has an infl uence on clotting of blood is the surface of the material the device is made of, numerous attempts has already been undertaken to modify surfaces of existing materials in order to provide necessary protection against clot formation, very often by coating the materials with bio-active substances. The aim of presented study was to create a coating of phosphatidylcholine that would mimic natural cell outer membrane on the surface of polyurethane — a material already in use in construction of cardiovascular implants. The obtained coated materials have been evaluated with the use of FT-IR/ATR spectroscopy. The change in contact angle of modifi ed material was also investigated. Finally in vitro cytotoxicity tests were performed in order to examine biocompatibility of obtained material.

Słowa kluczowe

EN

phosphatidylcholine; polyurethane; cell outer membrane mimetic surface; artificial heart

• Wydawca: Foundation for Young Scientists
• Czasopismo: Challenges of Modern Technology
• Rocznik: 2011
• Tom: Vol. 2, no. 4
• Strony: 7--10
• Opis fizyczny: Bibliogr. 7 poz., wykr., rys., fot.

Twórcy

autor

Trzaskowski M.

• Warsaw University of Technology, Faculty of Chemical and Process Engineering, Warynskiego 1, 00-645 Warsaw, Poland

autor

Butruk B.

autor

Ciach T.

Bibliografia

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• [3] Achala, de Mel, et al. “Biofunctionalization of Biomaterials for Accelerated in Situ Endothelialization: A Review.”, Biomacromolecules 9(11), 2008: 2969–2979.
• [4] Resiak, and Rokicki. “Modified polyurethanes for biomedical applications.” Polimery 45(9), 2000: 592--602.
• [5] Ming, and Yong. “Fabrication and biocompatibility of cell outer membrane.” Chinese Journal of Polymer Science 29(1), 2011: 53–64.
• [6] Nakabayashi, and Williams. “Preparation of non--thrombogenic materials using 2-methacryloyloxyethyl phosphorylcholine.” Biomaterials 24 (2003): 2431--2435.
• [7] Stalder, et al. “A Snake-Based Approach to Accurate Determination of Both Contact Points and Contact Angles.” Colloids And Surfaces: Physicochemical And Engineering Aspects 286(1–3), 2006: 92–103.