Analgesic and anti-inflammatory activities of some transition metal schiff base complexes

• Autorzy: Jesmin M. , Islam M. K. , Ali S. M. M.
• Języki publikacji: EN

Abstrakty

EN

Analgesic and anti-inflammatory activities of four transition metal complexes of a Schiff base derived from salicylaldehyde and glycine, viz. [N-salicylideneglycinato diaqua cobalt(II) dimer] (SGCo)2, [N-salicylideneglycinato-di-aqua-nickel(ll)dimer] (SGN)2, [N-salicylideneglycinato-aqua-copper(II)] (SGC) and [N-salicylideneglycinato diaqua zinc(II) dimer] (SGZ)2 were studied in swiss albino mice. 10 mg/kg (p.o) dose for each compound were selected throughout the research work. The analgesic activity was determined by acetic acid induced writhing and tail immersion methods. All such data were compared with standard drugs at the dose of 10 mg/kg (p.o. The anti-inflammatory activity of the test compounds was determined by the carragenan induced mice paw edema inhibition method.). Analgesic and anti-inflammatory activities of the test compounds at 10 mg/kg (p.o.) were quite comparable to those of standard drugs at 10 mg/kg (p.o.). All these compounds can be considered as potent analgesic and anti-inflammatory agents.

Słowa kluczowe

EN

Analgesic activity; Anti-inflammatory activity; Schiff bases complexes; Writhing test

• Wydawca: Przedsiębiorstwo Wydawnictw Naukowych "DARWIN"
• Czasopismo: International Letters of Chemistry, Physics and Astronomy
• Rocznik: 2014
• Tom: Vol. 8
• Strony: 64--72
• Opis fizyczny: Bibliogr. 25 poz., tab.

Twórcy

autor

Jesmin M.

• Department of Applied Chemistry and Chemical Engineering, University of Rajshahi, Rajshahi - 6205, Bangladesh

autor

Islam M. K.

• Department of Applied Chemistry and Chemical Engineering, Noakhali Science and Technology University, Noakhali - 3814, Bangladesh

autor

Ali S. M. M.

• Department of Applied Chemistry and Chemical Engineering, University of Rajshahi, Rajshahi - 6205, Bangladesh

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