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Identification of multiple constituents in shuganjieyu capsule and rat plasma after oral administration by ultra-performance liquid chromatography coupled with electrospray ionization and ion trap mass spectrometry

Identyfikatory
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Shuganjieyu (SGJY) capsule is a classical formula widely used in Chinese clinical application. In this paper, an ultra-performance liquid chromatography coupled with electrospray ionization and ion trap mass spectrometry has been established to separate and identify the chemical constituents of SGJY and the multiple constituents of SGJY in rats. The chromatographic separation was performed on a C18 RRHD column (150 × 2.1 mm, 1.8 μm), while 0.1% formic acid–water and 0.1% formic acid–acetonitrile was used as mobile phase. Mass spectral data were acquired in both positive and negative modes. On the basis of the characteristic retention time (Rt) and mass spectral data with those of reference standards and relevant references, 73 constituents from the SGJY and 15 ingredients including 10 original constituents and 5 metabolites from the rat plasma after oral administration of SGJY were identified or tentatively characterized. This study provided helpful chemical information for further pharmacology and active mechanism research on SGJY.
Rocznik
Strony
95--102
Opis fizyczny
Bibliogr. 45 poz., rys.
Twórcy
autor
  • Chengdu Kanghong Pharmaceutical Co. Ltd., Chengdu, Sichuan 610036, P.R. China
autor
  • Chengdu Kanghong Pharmaceutical Co. Ltd., Chengdu, Sichuan 610036, P.R. China
autor
  • Chengdu Kanghong Pharmaceutical Co. Ltd., Chengdu, Sichuan 610036, P.R. China
autor
  • Chengdu Kanghong Pharmaceutical Co. Ltd., Chengdu, Sichuan 610036, P.R. China
autor
  • Chengdu Kanghong Pharmaceutical Co. Ltd., Chengdu, Sichuan 610036, P.R. China
autor
  • Chengdu Kanghong Pharmaceutical Co. Ltd., Chengdu, Sichuan 610036, P.R. China
autor
  • Chengdu Kanghong Pharmaceutical Co. Ltd., Chengdu, Sichuan 610036, P.R. China
autor
  • Chengdu Kanghong Pharmaceutical Co. Ltd., Chengdu, Sichuan 610036, P.R. China
autor
  • Chengdu Kanghong Pharmaceutical Co. Ltd., Chengdu, Sichuan 610036, P.R. China
autor
  • Chengdu Kanghong Pharmaceutical Co. Ltd., Chengdu, Sichuan 610036, P.R. China
autor
  • Chengdu Kanghong Pharmaceutical Co. Ltd., Chengdu, Sichuan 610036, P.R. China
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Uwagi
PL
Opracowanie rekordu w ramach umowy 509/P-DUN/2018 ze środków MNiSW przeznaczonych na działalność upowszechniającą naukę (2018).
Typ dokumentu
Bibliografia
Identyfikator YADDA
bwmeta1.element.baztech-1e195c6e-bad8-4d04-9177-283b4947b28b
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