Identification of multiple constituents in shuganjieyu capsule and rat plasma after oral administration by ultra-performance liquid chromatography coupled with electrospray ionization and ion trap mass spectrometry

• Autorzy: Xiao Y. C. , Liu L. T. , Bian J. J. , Yan C. Q. , Ye L. , Zhao M. X. , Huang Q. S. , Wang W. , Liang K. , Shi Z. F. , Ke X.

Identyfikatory

DOI

10.1556/1326.2017.00094

• Języki publikacji: EN

Abstrakty

EN

Shuganjieyu (SGJY) capsule is a classical formula widely used in Chinese clinical application. In this paper, an ultra-performance liquid chromatography coupled with electrospray ionization and ion trap mass spectrometry has been established to separate and identify the chemical constituents of SGJY and the multiple constituents of SGJY in rats. The chromatographic separation was performed on a C18 RRHD column (150 × 2.1 mm, 1.8 μm), while 0.1% formic acid–water and 0.1% formic acid–acetonitrile was used as mobile phase. Mass spectral data were acquired in both positive and negative modes. On the basis of the characteristic retention time (Rt) and mass spectral data with those of reference standards and relevant references, 73 constituents from the SGJY and 15 ingredients including 10 original constituents and 5 metabolites from the rat plasma after oral administration of SGJY were identified or tentatively characterized. This study provided helpful chemical information for further pharmacology and active mechanism research on SGJY.

Słowa kluczowe

EN

Constituents; rat plasma; UHPLC–ESI–MS/MS; Shuganjieyu capsule

• Wydawca: University of Silesia in Katowice ; Akademiai Kiado
• Czasopismo: Acta Chromatographica
• Rocznik: 2018
• Tom: Vol. 30, no. 2
• Strony: 95--102
• Opis fizyczny: Bibliogr. 45 poz., rys.

Twórcy

autor

Xiao Y. C.

• Chengdu Kanghong Pharmaceutical Co. Ltd., Chengdu, Sichuan 610036, P.R. China

autor

Liu L. T.

• Chengdu Kanghong Pharmaceutical Co. Ltd., Chengdu, Sichuan 610036, P.R. China

autor

Bian J. J.

• Chengdu Kanghong Pharmaceutical Co. Ltd., Chengdu, Sichuan 610036, P.R. China

autor

Yan C. Q.

• Chengdu Kanghong Pharmaceutical Co. Ltd., Chengdu, Sichuan 610036, P.R. China

autor

Ye L.

• Chengdu Kanghong Pharmaceutical Co. Ltd., Chengdu, Sichuan 610036, P.R. China

autor

Zhao M. X.

• Chengdu Kanghong Pharmaceutical Co. Ltd., Chengdu, Sichuan 610036, P.R. China

autor

Huang Q. S.

• Chengdu Kanghong Pharmaceutical Co. Ltd., Chengdu, Sichuan 610036, P.R. China

autor

Wang W.

• Chengdu Kanghong Pharmaceutical Co. Ltd., Chengdu, Sichuan 610036, P.R. China

autor

Liang K.

• Chengdu Kanghong Pharmaceutical Co. Ltd., Chengdu, Sichuan 610036, P.R. China

autor

Shi Z. F.

• Chengdu Kanghong Pharmaceutical Co. Ltd., Chengdu, Sichuan 610036, P.R. China

autor

Ke X.

• Chengdu Kanghong Pharmaceutical Co. Ltd., Chengdu, Sichuan 610036, P.R. China

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Uwagi

PL

Opracowanie rekordu w ramach umowy 509/P-DUN/2018 ze środków MNiSW przeznaczonych na działalność upowszechniającą naukę (2018).