Preparation and anatomical distribution study of 67Ga-alginic acid nanoparticles for SPECT purposes in rainbow trout (Oncorhynchus mykiss)

• Autorzy: Heidarieh M. , Daryalal F. , Mirvaghefi A. , Rajabifar S. , Diallo A. , Sadeghi M. , Zeiai F. , Moodi S. , Maadi E. , Sheikhzadeh N. , Heidarieh H. , Hedyati M.

Identyfikatory

DOI

10.2478/nuka-2014-0019

• Języki publikacji: EN

Abstrakty

EN

Ergosan contains 1% alginic acid extracted from two brown sea weeds. Little is known about the target organs and anatomical distribution of Ergosan (alginic acid) in fi sh. Therefore, feasibility of developing alginic acid nanoparticles to detect target organ in rainbow trout is interesting. To make nanoparticles, Ergosan extract (alginic acid) was irradiated at 30 kGy in a cobalt-60 irradiator and characterized by transmission electron microscopy (TEM) and Fourier transform infrared spectroscopy (FTIR). Results from TEM images showed that particle sizes of irradiated alginic acid ranged from 30 to 70 nm. The FTIR results indicated that gamma irradiation had no signifi cant infl uence on the basic structure of alginic acid. Later, alginic acid nanoparticles were successively labelled with 67Ga-gallium chloride. The biodistribution of irradiated Ergosan in normal rainbow trout showed highest uptake in intestine and kidney and then in liver and kidney at 4- and 24-h post injection, respectively. Single-photon emission computed tomography (SPECT) images also demonstrated target specifi c binding of the tracer at 4- and 24-h post injection. In conclusion, the feed supplemented with alginic acid nanoparticles enhanced SPECT images of gastrointestinal morphology and immunity system in normal rainbow trout.

Słowa kluczowe

EN

rainbow trout; 67Ga; intestine; SPECT; alginic acid nanoparticles; gamma irradiation

• Wydawca: Institute of Nuclear Chemistry and Technology
• Czasopismo: Nukleonika
• Rocznik: 2014
• Tom: Vol. 59, No. 4
• Strony: 153--159
• Opis fizyczny: Bibliogr. 28 poz., rys.

Twórcy

autor

Heidarieh M.

• Nuclear Science and Technology Research Institute, Karaj, Iran, Tel.: [phone]

autor

Daryalal F.

• Department of Fisheries and Environment Science, Faculty of Natural Resources, University of Tehran, Tehran, Iran

autor

Mirvaghefi A.

• Department of Fisheries and Environment Science, Faculty of Natural Resources, University of Tehran, Tehran, Iran

autor

Rajabifar S.

• Nuclear Science and Technology Research Institute, Karaj, Iran, Tel.: [phone]

autor

Diallo A.

• Animal Production and Health Laboratory, International Atomic Energy Agency (IAEA), Vienna, Austria

autor

Sadeghi M.

• Nuclear Science and Technology Research Institute, Karaj, Iran, Tel.: [phone]

autor

Zeiai F.

• Nuclear Science and Technology Research Institute, Karaj, Iran, Tel.: [phone]

autor

Moodi S.

• Nuclear Science and Technology Research Institute, Karaj, Iran, Tel.: [phone]

autor

Maadi E.

• Nuclear Science and Technology Research Institute, Karaj, Iran, Tel.: [phone]

autor

Sheikhzadeh N.

• Department of FoodHygiene and Aquatic Animals, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran

autor

Heidarieh H.

• Islamic Azad University, Branch of Kazeroon, Kazeroon, Iran

autor

Hedyati M.

• Department of Fisheries and Environment Science, Faculty of Natural Resources, University of Tehran, Tehran, Iran

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