Evaluation of repair of osteochondral defects in rabbits using new composite biomaterials during three-month observation

• Autorzy: Żylińska B. , Stodolak-Zych E. , Nowicka K. , Silmanowicz P.
• Języki publikacji: EN

Abstrakty

EN

In this work nanocomposite porous pins were implanted into rabbit knees. The pins were made of biodegradable synthetic poly-L/DL-lactide (80:20) which was modified with nanometric hydroksyapatite particles (HAp) and covered with biopolymer layer of sodium alginate (NA). In vivo experiments were conducted on a 4-element group of the New Zealand rabbits. Osteogenesis was observed using scanning electron microscope (SEM/EDS) after 12 weeks of implantation.

Słowa kluczowe

EN

osteochondral defects; regenerative medicine; scaffolds; hydroksyapatite; alginate

• Wydawca: Polish Society for Biomaterials in Cracow
• Czasopismo: Engineering of Biomaterials
• Rocznik: 2012
• Tom: Vol. 15, no. 116-117 spec. iss.
• Strony: 118--119
• Opis fizyczny: Bibliogr. 7 poz., rys., wykr.

Twórcy

autor

Żylińska B.

• UP-University of Life Sciences in Lublin, Faculty of Veterinary Medicine, Department and Clinic of Animal Surgery, 30 Głęboka Str., 20-612 Lublin, Poland

autor

Stodolak-Zych E.

• AGH-University of Science and Technology, Faculty of Materials Science and Ceramics, Department of Biomaterials, 30 Mickiewicza Ave, 30-059 Krakow, Poland

autor

Nowicka K.

• AGH-University of Science and Technology, Faculty of Materials Science and Ceramics, Department of Biomaterials, 30 Mickiewicza Ave, 30-059 Krakow, Poland

autor

Silmanowicz P.

• UP-University of Life Sciences in Lublin, Faculty of Veterinary Medicine, Department and Clinic of Animal Surgery, 30 Głęboka Str., 20-612 Lublin, Poland

Bibliografia

• [1] Xiaoxiao Cai, Yunfeng Lin, Guomin Ou, En Luo, Yi Man, Quan Yuan, Ping Gong, Ectopic osteogenesis and chondrogenesis of bone marrow stromal stem cells in alginate system, Cell Biology International 31 (2007) 776-783.
• [2] Tuli R, Seghatoleslami MR, Tuli S, Wang ML, Hozack WJ, Manner PA, Danielson KG, Tuan RS: A simple, high-yield method for obtaining multipotential mesenchymal progenitor cells from trabecular bone. Mol Biotechnol 2003, 23:37-49.
• [3] Schaefer D, Martin I, Shastri P, Padera RF, Langer R, Freed LE, Vunjak-Novakovic G: In vitro generation of osteochondral composites. Biomaterials 2000, 21:2599-2606.
• [4] Caterson EJ, Nesti LJ, Li WJ, Danielson KG, Albert TJ, Vaccaro AR, Tuan RS: Three-dimensional cartilage formation by bone marrow-derived cells seeded in polylactide/alginate amalgam J Biomed Mater Res 2001, 57:394-403
• [5] Marijnissen WJ, van Osch GJ, Aigner J, Verwoerd-Verhoef HL, Verhaar JA: Tissue-engineered cartilage using serially passaged articular chondrocytes. Chondrocytes in alginate, combined in vivo with a synthetic (E210) or biologic biodegradable carrier (DBM). Biomaterials 2000, 21:571-580.
• [6] Sherwood JK, Riley SL, Palazzolo R, Brown SC, Monkhouse DC, Coates M, Griffith LG, Landeen LK, Ratcliffe A: A three-dimensional osteochondral composite scaffold for articular cartilage repair. Biomaterials 2002, 23:4739-4751.
• [7] A. Frączek-Szczypta, E. Stodolak, A. Wiecheć, M. Błażewicz: Preliminary investigations of polylactide-based nanocomposites as potential materials for bone cells proliferation, Engineering of Biomaterials 2010, 96-98: 1-3.