Fabrication of Pure Electrospun Materials from Hyaluronic Acid

• Autorzy: Pabjańczyk-Wlazło E. , Krucińska I. , Chrzanowski M. , Szparaga G. , Chaberska A. , Kolesińska B. , Komisarczyk A. , Boguń M.

Identyfikatory

DOI

10.5604/12303666.1237225

Warianty tytułu

PL

Materiały z kwasu hialuronowego otrzymywane metodą elektroprzędzenia przeznaczone do zastosowań w inżynierii tkankowej

• Języki publikacji: EN

Abstrakty

EN

The aim of the research was to develop optimal conditions for manufacturing materials based on hyaluronic acid by the electrospun method. The studies were composed of three stages: the process of selection of the optimal solvent (mixture of solvents), the molecular weight of hyaluronic acid, and the concentration of biopolymer in the spinning solution. The influence of variable parameters on the rheological properties of the spinning solutions and electrospinning trails was tested. Depending on the electrospinning regime applied, the fibers obtained were characterised by a diameter of the order of 20 to 400 nm. As a result of the development works presented, an optimal molecular weight of the polymer, its concentration and system of solvents were determined, together with process parameters, ensuring a stable electrospinning process and relatively homogeneous nanofibers. Additionally studies on the residues of solvents used during electrosun formation were done and parameters of drying of the final materials were examined. This approach (verification of the presence of organic solvent residue in the nanofibrous formed) is important for the suitability of nanofibres as scaffolds for regenerative medicine. This study provides an opportunity for the understanding and identification of process parameters, allowing for predictable manufacturing nanofibers based on natural biopolymers, which makes it tremendously beneficial in terms of customisation.

PL

Celem badań było opracowanie optymalnych warunków otrzymywania nanowłókien z kwasu hialuronowego. Badania obejmowały następujące etapy realizacji pracy: proces doboru optymalnego rozpuszczalnika dla polimeru oraz dobór masy cząsteczkowej kwasu hialuronowego. Zbadano właściwości reologiczne roztworów oraz wpływ zmiennych parametrów procesowych na strukturę mikroskopową włókien. W zależności od zastosowanych parametrów elektroprzędzenia otrzymane włókna charakteryzowały się średnią rzędu od 20 do 400 nm. Dodatkowo przeprowadzono badania dotyczące pozostałości rozpuszczalników stosowanych w przygotowaniu roztworów przędzalniczych, co jest istotne z punktu widzenia wykorzystania tych materiałów w obrębie medycyny regeneracyjnej.

Słowa kluczowe

EN

biocompatible polymers; natural polymers; biomimetism; biomimetic scaffolds; regenerative medicine; electrospinning; hyaluronic acid

PL

polimery biokompatybilne; polimery naturalne; biomimetyzm; szkielety biomimetyczne; medycyna regeneracyjna; elektrospining; kwas hialuronowy

• Wydawca: Sieć Badawcza Łukasiewicz - Łódzki Instytut Technologiczny
• Czasopismo: Fibres & Textiles in Eastern Europe
• Rocznik: 2017
• Tom: Vol. 25, no. 3 (123)
• Strony: 45--52
• Opis fizyczny: Bibliogr. 25 poz., rys., tab.

Twórcy

autor

Pabjańczyk-Wlazło E.

• Lodz University of Technology, Faculty of Material Technologies and Textile Design, Department of Material and Commodity Sciences and Textile Metrology, Zeromskiego Str. 116, 90-924 Lodz, Poland

autor

Krucińska I.

• Lodz University of Technology, Faculty of Material Technologies and Textile Design, Department of Material and Commodity Sciences and Textile Metrology, Zeromskiego Str. 116, 90-924 Lodz, Poland

autor

Chrzanowski M.

• Lodz University of Technology, Faculty of Material Technologies and Textile Design, Department of Material and Commodity Sciences and Textile Metrology, Zeromskiego Str. 116, 90-924 Lodz, Poland

autor

Szparaga G.

• Lodz University of Technology, Faculty of Material Technologies and Textile Design, Department of Material and Commodity Sciences and Textile Metrology, Zeromskiego Str. 116, 90-924 Lodz, Poland

autor

Chaberska A.

• Lodz University of Technology, Faculty of Chemistry, Institute of Organic Chemistry, Zeromskiego Str. 116, 90-924 Lodz Poland

autor

Kolesińska B.

• Lodz University of Technology, Faculty of Chemistry, Institute of Organic Chemistry, Zeromskiego Str. 116, 90-924 Lodz Poland

autor

Komisarczyk A.

• Lodz University of Technology, Faculty of Material Technologies and Textile Design, Department of Material and Commodity Sciences and Textile Metrology, Zeromskiego Str. 116, 90-924 Lodz, Poland

autor

Boguń M.

• Lodz University of Technology, Faculty of Material Technologies and Textile Design, Department of Material and Commodity Sciences and Textile Metrology, Zeromskiego Str. 116, 90-924 Lodz, Poland

Bibliografia

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Uwagi

Opracowanie ze środków MNiSW w ramach umowy 812/P-DUN/2016 na działalność upowszechniającą naukę (zadania 2017).