Investigation of imaging properties of novel contrast agents based on gold, silver and bismuth nanoparticles in spectral computed tomography using Monte Carlo simulation

• Autorzy: Sadeghian Maryam , Akhlaghi Parisa , Mesbahi Asghar

Identyfikatory

DOI

10.2478/pjmpe-2020-0003

• Języki publikacji: EN

Abstrakty

EN

In the present paper, some imaging properties of nanoparticles-based contrast agents including gold, bismuth, and silver were assessed and compared with conventional (iodinated) contrast agent in spectral computed tomography (CT). A spectral CT scanner with photon-counting detectors (PCD) and 6 energy bins was simulated using the Monte Carlo (MC) simulation method. The nanoparticles were designed with a diameter of 50 nm at concentrations of 2, 4, and 8 mg/ml. Water-filled cylindrical phantom was modeled with a diameter of 10 cm containing a hole with a diameter of 5 cm in its center, where was filled with contrast agents. The MC results were used to reconstruct images. Image reconstruction was accomplished with the filtered back-projection (FBP) method with hamming filter and linear interpolation method. CT number and contrast-to-noise ratio (CNR) of all studied contrast materials were calculated in spectral images. The simulations indicated that nanoparticle-based contrast agents have a higher CT number and CNR than the iodinated contrast agent at the same concentration and for all energy bins. In general, gold nanoparticles produced the highest CT number and CNR compared to silver and bismuth nanoparticles at the same concentration. However, at low energies (below 80 keV), silver nanoparticles performed similarly to gold nanoparticles and at high energies (120 keV), bismuth nanoparticles can be a good substitute for gold nanoparticles.

Słowa kluczowe

EN

spectral CT; photon counting detectors; contrast agent; Monte Carlo simulation; nanoparticles

• Wydawca: Polskie Towarzystwo Fizyki Medycznej ; De Gruyter
• Czasopismo: Polish Journal of Medical Physics and Engineering
• Rocznik: 2020
• Tom: Vol. 26, Iss. 1
• Strony: 21--29
• Opis fizyczny: Bibliogr. 37 poz., rys., tab.

Twórcy

autor

Sadeghian Maryam

• Medical Radiation Sciences Research Team, Tabriz University of Medical Sciences, Tabriz
• Medical Physics Department, Medical School, Tabriz University of Medical Sciences, Tabriz

autor

Akhlaghi Parisa

• Medical Radiation Sciences Research Team, Tabriz University of Medical Sciences, Tabriz
• Medical Physics Department, Medical School, Tabriz University of Medical Sciences, Tabriz

autor

Mesbahi Asghar

• Molecular Medicine Research Center, Tabriz University of Medical Sciences, Tabriz

Bibliografia

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Uwagi

Opracowanie rekordu ze środków MNiSW, umowa Nr 461252 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2020).