Verapamil uptake into human blood platelets

• Autorzy: Kędziora P. , Króliczak V. , Walkowiak B.
• Konferencja: International Student Symposium on Mechanics, Microtechnology and Microcomputers "STUSYM`2000" (XIII ; Łódź, Polska)
• Języki publikacji: EN

Abstrakty

EN

Preliminary results of verapamil uptake into human blood platelets are presented. Fluorescence labeled verapamil (BODIPY-verapamil) was incorporated into blood platelets, and saturation of uptake was observed within 30 minutes. The uptake of BODIPY-verapamil was inhibited by unlabeled one. The number of binding sites is about 2.5x 105 per platelet, and apparent dissociation constant is 1.1±0.5xl05M. Plasma proteins can effectively bound verapamil and this makes it possible to maintain the constant level of the drug in blood.

Słowa kluczowe

EN

verapamil; blood platelets; saturation; BODIPY-verapamil

• Wydawca: Wydawnictwo Politechniki Łódzkiej
• Czasopismo: Mechanics and Mechanical Engineering
• Rocznik: 2000
• Tom: Vol. 4, nr 1
• Strony: 75--80
• Opis fizyczny: Bibliogr. 10 poz.

Twórcy

autor

Kędziora P.

• Institute of Materials Engineering, Technical University of Lodz, 1/5 Stefanowskiego St., 90-924 Lodz, Poland

autor

Króliczak V.

• Institute of Materials Engineering, Technical University of Lodz, 1/5 Stefanowskiego St., 90-924 Lodz, Poland

autor

Walkowiak B.

• Institute of Materials Engineering, Technical University of Lodz, 1/5 Stefanowskiego St., 90-924 Lodz, Poland
• Department of Biophysics, Medical University of Lodz, 3 Lindley St., 90-131 Lodz, Poland Tel: [phone]