Investigations of polycaprolactone/gelatin blends in terms of their miscibility

• Autorzy: Kolbuk D. , Sajkiewicz P. , Denis P. , Choinska E.
• Języki publikacji: EN

Abstrakty

EN

Synthetic and natural polymers blends represent a new brand of materials with application in wound healing, scaffolds or drug delivery systems. Polycaprolactone/gelatin (PCL/Gt) blends were analyzed in terms of their miscibility. The PCL structure was investigated as a function of Gt content. Changes in the PCL spherulitic structure with Gt content were investigated by a polarizing-interference microscope. The analysis of the glass transition temperature (Tg) of both components as a function of PCL/Gt ratio by differential scanning calorimetry indicates that the system of polycaprolactone/gelatin belongs to a type of s.c. compatible system, being intermediate between miscible and immiscible systems. There is possibility of very limited miscibility of both components. Supplementary wide angle X-ray scattering results are presented.

Słowa kluczowe

EN

blends; compatibility; miscibility; polycaprolactone; gelatin

• Wydawca: Polska Akademia Nauk, Wydział IV Nauk Technicznych
• Czasopismo: Bulletin of the Polish Academy of Sciences. Technical Sciences
• Rocznik: 2013
• Tom: Vol. 61, nr 3
• Strony: 629--632
• Opis fizyczny: Bibliogr. 14 poz., wykr., rys., tab.

Twórcy

autor

Kolbuk D.

• Institute of Fundamental Technological Research, Polish Academy of Sciences, 5b Pawińskiego St., 02-106 Warszawa, Poland

autor

Sajkiewicz P.

• Institute of Fundamental Technological Research, Polish Academy of Sciences, 5b Pawińskiego St., 02-106 Warszawa, Poland

autor

Denis P.

• Institute of Fundamental Technological Research, Polish Academy of Sciences, 5b Pawińskiego St., 02-106 Warszawa, Poland

autor

Choinska E.

• Faculty of Materials Engineering, Warsaw University of Technology, 141 Wołoska St., 02-507 Warszawa, Poland

Bibliografia

• [1] E.D. Coland, J.A. Matthews, K.J. Pawlowski, D.G. Sompson, G.E. Wnek, and L. Gary, “Electrospinning collagen and elastin: preliminary vascular tissue engineering”, Front Biosci. 9, 1432-42 (2004).
• [2] L. Buttafoco, N.G. Kolkman, P. Engbers-Buijtenhuijs, A.A. Poot, P.J. Dijkstra, I. Vermes, and J. Feijen, “Electrospinning of collagen and elastin for tissue engineering applications”, Biomaterials 27, 724-734 (2006).
• [3] M.R. Williamson, R. Black, and C. Kielty, “PCL-PU composite vascular scaffold production for vascular tissue engineering: attachment, proliferation and bioactivity of human vascular endothelial cells”, Biomaterials 27, 3608-3616 (2006).
• [4] E.J. Chong, T.T. Phan, I.J. Lim, Y.Z. Zhang, B.H. Bay, S. Ramakrishna, and C.T. Lim, “Evaluation of electrospun PCL/gelatin nanofibrous scaffold for wound healing and layered dermal reconstitution”, Acta Biomater. 3 (3), 321-330 (2007).
• [5] J.J. Lee, H.S. Yu, S.J. Hong, I. Jeong, J.H. Jang, and H.W. Kim, “Nanofibrous membrane of collagen-polycaprolactone for cell growth and tissue regeneration”, J. Mater. Sci. Mater. Med. 9, 1927-35 (2009).
• [6] M.V. Jose, V. Thomas, D.R. Dean, and E. Nyairo, “Fabrication and characterization of aligned nanofibrous PLGA/Collagen blends as bone tissue scaffolds”, Polymer 50, 3778-3785 (2009).
• [7] A. Sionkowska, J. Skopinska-Wisniewska, and M. Wisniewski, “Collagen - synthetic polymer interactions in solution and in thin films”, J. Molecular Liquids 145, 135-138 (2009).
• [8] Y.Z. Zhang, Y. Feng, Z.M. Huang, S. Ramakrishna, and C.T. Lim, “Fabrication of porous electrospun nanofibres”, Nanotechnology 17, 901-908 (2006).
• [9] O. Hartman, Ch. Zhang, E.L. Adams, M.C. Farach-Carson, N.J. Petrelli, B.D. Chasea, and J.F. Rabolt, “Biofunctionalization of electrospun PCL-based scaffolds with perlecan domain IV peptide to create a 3-D pharmacokinetic cancer model”, Biomaterials 31 (21), 5700-18 (2010).
• [10] Y. Zhang, H. Ouyang, C.T. Lim, S. Ramakrishna, and Z.- M. Huang, “Electrospinning of gelatin fibers and gelatin/PCL composite fibrous scaffolds”, Appl. Biomater. 72B, 156 -165 (2005).
• [11] X. Yang, Q. Xu, G. Sui, Q. Ca, and X. Deng, “Structure and wettability relationship of coelectrospun poly (L-lactic acid)/gelatin composite fibrous mats”, Polym. Adv. Technol. 22, 2222-2230 (2011).
• [12] E.M. Woo, T.K. Mandal, S.C. Lee, “Relationship between ringed spherulitic morphology and miscibility in blends of poly(e-caprolactone) with poly(benzyl methacrylate) versus poly(phenyl methacrylate)”, Colloid Polymer Science 278, 1032-1042 (2000).
• [13] W. Brostow, R. Chiu, I.M. Kalogeras, and A. Vassilikou-Dova, “Prediction of glass transition temperatures: Binary blends and copolymers”, Materials Letters 62, 3152-3155 (2008).
• [14] E.S. Gil, D.J. Frankowski, M.K. Bowman, A.O. Gozen, S.M. Hudson, and R.J. Spontak, “Mixed protein blends composed of gelatin and Bombyx mori silk fibroin: effects of solventinduced crystallization and composition”, Biomacromolecules 7, 728-735 (2006).