The influence of supercritical foaming conditions on properties of polymer scaffolds for tissue engineering

• Autorzy: Kosowska K. , Henczka M.

Identyfikatory

DOI

10.1515/cpe-2017-0042

• Języki publikacji: EN

Abstrakty

EN

The results of experimental investigations into foaming process of poly(ε-caprolactone) using supercritical CO2 are presented. The objective of the study was to explore the aspects of fabrication of biodegradable and biocompatible scaffolds that can be applied as a temporary three-dimensional extracellular matrix analog for cells to grow into a new tissue. The influence of foaming process parameters, which have been proven previously to affect significantly scaffold bioactivity, such as pressure (8-18 MPa), temperature (323-373 K) and time of saturation (1-6 h) on microstructure and mechanical properties of produced polymer porous structures is presented. The morphology and mechanical properties of considered materials were analyzed using a scanning electron microscope (SEM), x-ray microtomography (μ-CT) and a static compression test. A precise control over porosity and morphology of obtained polymer porous structures by adjusting the foaming process parameters has been proved. The obtained poly(ε-caprolactone) solid foams prepared using scCO2 have demonstrated sufficient mechanical strength to be applied as scaffolds in tissue engineering.

Słowa kluczowe

EN

supercritical fluids; supercritical foaming; poly(ε-caprolactone); tissue engineering; scaffold

PL

płyny nadkrytyczne; pienienie nadkrytyczne; inżynieria tkankowa; szafot

• Wydawca: Komitet Inżynierii Chemicznej i Procesowej Polskiej Akademii Nauk
• Czasopismo: Chemical and Process Engineering
• Rocznik: 2017
• Tom: Vol. 38, nr 4
• Strony: 535--541
• Opis fizyczny: Bibliogr. 20 poz., tab., rys.

Twórcy

autor

Kosowska K.

• Warsaw University of Technology, Faculty of Chemical and Process Engineering, Waryńskiego 1, 00 - 645 Warsaw, Poland

autor

Henczka M.

• Warsaw University of Technology, Faculty of Chemical and Process Engineering, Waryńskiego 1, 00 - 645 Warsaw, Poland

Bibliografia

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Uwagi

PL

Opracowanie ze środków MNiSW w ramach umowy 812/P-DUN/2016 na działalność upowszechniającą naukę (zadania 2017)