Physiochemical and biological evaluation of thin CNTs layers

• Autorzy: Benko A. , Przekora A. , Nocuń M. , Wesełucha-Birczyńska A. , Ginalska G. , Błażewicz M.
• Konferencja: 24th Conference on Biomaterials in medicine and veterinary medicine : 9--12 October 2014, Rytro, Poland
• Języki publikacji: EN

Abstrakty

EN

Carbon nanotubes are nanometric-sized materiale which possess a set of interesting features that favor their applications in various fields of materials engineering, including biomedical applications. However, their usage as implants or in nanomedicine raises many questions, regarding their potential cytotoxicity, relative to their length, diameter, structure and functional groups, present on their outer walls. The given study presents a physiochemical and biological in vitro (in accordance with EN-ISO 10993-5) evaluation of thin carbon nanotubes films, deposited on the surface of titanium, by means of the EPD process. Experiments were carried out on commercially available, pre-functionalized with OH groups, multi-walled carbon nanotubes. The obtained material is proven to be biocompatible, with no cytotoxic effect on the human fetal osteoblast cell line. During the study, selectivity of the EPD process was proven - performed experiments revealed that the process favors deposition of CNTs with chosen set of features from the stock solution. Presented results point out that the EPD process can be successfully applied as a method for fractioning the CNTs, aimed to fabricate non-toxic layers that might be considered for various biomedical applications.

Słowa kluczowe

EN

EPD; MWCNTs; thin layers; biocompatibility

• Wydawca: Polish Society for Biomaterials in Cracow
• Czasopismo: Engineering of Biomaterials
• Rocznik: 2014
• Tom: Vol. 17, no. 128-129
• Strony: 93--94
• Opis fizyczny: Bibliogr. 7 poz.

Twórcy

autor

Benko A.

• AGH University of Science and Technology, Faculty of Materials Science and Ceramics, Department of Biomaterials, 30 Mickiewicza Ave., 30-059 Krakow, Poland

autor

Przekora A.

• Department of Biochemistry and Biotechnology, Medical University of Lublin, Faculty of Pharmacy with Medical Analytics Division, 1 Chodzki Str., 20-093 Lublin, Poland

autor

Nocuń M.

• AGH University of Science and Technology, Faculty of Materials Science and Ceramics, Department of Biomaterials, 30 Mickiewicza Ave., 30-059 Krakow, Poland

autor

Wesełucha-Birczyńska A.

• Department of Chemical Physics, Faculty of Chemistry, Jagiellonian University, 3 Ingardena Str., 30-060, Krakow, Poland

autor

Ginalska G.

• Department of Biochemistry and Biotechnology, Medical University of Lublin, Faculty of Pharmacy with Medical Analytics Division, 1 Chodzki Str., 20-093 Lublin, Poland

autor

Błażewicz M.

• AGH University of Science and Technology, Faculty of Materials Science and Ceramics, Department of Biomaterials, 30 Mickiewicza Ave., 30-059 Krakow, Poland

Bibliografia

• [1] Demczyk, B.G., et al., Direct mechanical measurement of the tensile strength and elastic modulus of multiwalled carbon nanotubes. Materials Science and Engineering: A, 2002. 334(1–2): p. 173-178.
• [2] Kwon, O.-S., et al., Fabrication and characterization of inkjet-printed carbon nanotube electrode patterns on paper. Carbon, 2013. 58(0): p. 116-127.
• [3] Harrison, B.S. and A. Atala, Carbon nanotube applications for tissue engineering. Biomaterials, 2007. 28(2): p. 344-353.
• [4] Foldvari, M. and M. Bagonluri, Carbon nanotubes as functional excipients for nanomedicines: I. pharmaceutical properties. Nanomedicine: Nanotechnology, Biology and Medicine, 2008. 4(3): p. 173-182.
• [5] Foldvari, M. and M. Bagonluri, Carbon nanotubes as functional excipients for nanomedicines: II. Drug delivery and biocompatibility issues. Nanomedicine: Nanotechnology, Biology and Medicine, 2008. 4(3): p. 183-200.
• [6] Justino, C.I.L., et al., Advances in point-of-care technologies with biosensors based on carbon nanotubes. TrAC Trends in Analytical Chemistry, 2013. 45(0): p. 24-36.
• [7] Lanone, S., et al., Determinants of carbon nanotube toxicity. Advanced Drug Delivery Reviews, 2013. 65(15): p. 2063-2069.

Uwagi

EN

This work has been supported by National Science Centre (NCN) grants Nos.: 2011/01/B/ST5/06424.