Synthesis, characterisation and biological screening of s - triazine based chalcones and its derivatization into phenyl pyrazolines, isoxazoles

• Autorzy: Solankee A. , Tailor R.

Identyfikatory

DOI

10.18052/www.scipress.com/ILCPA.47.109

• Języki publikacji: EN

Abstrakty

EN

Heterocyclic derivatives such as phenyl pyrazolines and isoxaxoles were prepared from s - triazine based chalcones. Chalcones (A₁ - A₅) are synthesised by the reaction of compound (V) with various aromatic aldehydes. Moreover, further reaction of chalcones with phenyl hydrazine hydrochloride and hydroxylamine hydrochloride in the presence of alkali gives phenyl pyrazolines (A₆ - A₁₀) and isoxazoles (A₁₁ - A₁₅) derivatives respectively. The structures of the newly synthesised compounds were confiremed by spectroscopic (IR, ¹H NMR, ¹³C NMR) and elemental analysis. All the newly synthesised compounds have been screened for their antimicrobial activity against selected Gram - positive (S. aureus and S. pyogenus), Gram - negative (E. coli and P. aeruginosa) bacterial and fungal strains (C. albicans, A. niger and A. clavatus).

Słowa kluczowe

EN

chalcones; phenyl pyarazolines; isoxazoles; spectral data; elemental analysis; antimicrobial activity

• Wydawca: Przedsiębiorstwo Wydawnictw Naukowych "DARWIN"
• Czasopismo: International Letters of Chemistry, Physics and Astronomy
• Rocznik: 2015
• Tom: Vol. 47
• Strony: 109--119
• Opis fizyczny: Bibliogr. 30 poz., wz.

Twórcy

autor

Solankee A.

• Department of Chemistry, B. K. M. Science College, Valsad - 396001

autor

Tailor R.

• Department of Chemistry, B. K. M. Science College, Valsad - 396001

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