Monte Carlo characterization of the gold nanoparticles dose enhancement and estimation of the physical interactions weight in dose enhancement mechanism

• Autorzy: Mohammadzadeh Mohammad , Ghiasi Hosein

Identyfikatory

DOI

10.2478/pjmpe-2020-0026

• Języki publikacji: EN

Abstrakty

EN

Radiosensitization of the cancer cells by the heavy atoms of nanoparticles was the subject of some studies. But, the physical characterization to determine the weight of all interactions hasn’t been made numerically. The aim of this study was to calculate and compare the dose enhancement (DE) for different energies. The Monte Carlo simulation method was used in the current study. The influence of gold nanoparticles (GNP) size, beam quality, the GNP concentration, and dose inhomogeneity on the radiosensitization by DE was studied. A 35% increase in the photoelectric effect was observed while energy decreased from 18 MV to 300 kV. In the microscopic study which DE calculated in 30 μm from a single GNP, a 79% decreasing in DE within the first 1μm was seen and it declined to 2% in 30 μm from the GNP center. The effect was observed at small distances only. Our study revealed that the dose inhomogeneity around a nanoparticle is the main and very strong effect of DE on a macroscopic scale. In the location which 35% DE occurs most malignant cells survival will be effectively reduced. Our research indicates the need for further research.

Słowa kluczowe

EN

gold nanoparticles; dose enhancement; Monte Carlo

• Wydawca: Polskie Towarzystwo Fizyki Medycznej ; De Gruyter
• Czasopismo: Polish Journal of Medical Physics and Engineering
• Rocznik: 2020
• Tom: Vol. 26, Iss. 4
• Strony: 217--223
• Opis fizyczny: Bibliogr. 27 poz., rys., tab.

Twórcy

autor

Mohammadzadeh Mohammad

• Radiation Oncology Department, Shaid Madani Hospital. Tabriz, Iran
• Medical Radiation Sciences Research Team, Imam Hospital, Tabriz University of Medical Sciences, Tabriz, Iran

autor

Ghiasi Hosein

• Radiation Oncology Department, Shaid Madani Hospital. Tabriz, Iran
• Medical Radiation Sciences Research Team, Imam Hospital, Tabriz University of Medical Sciences, Tabriz, Iran

Bibliografia

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Uwagi

Opracowanie rekordu ze środków MNiSW, umowa Nr 461252 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2021).