Study on the Effect of in Situ Surface Treatments of Medical Microfluidic Systems Obtained Through Additive Manufacturing

• Autorzy: Csapai Alexandra , Țoc Dan-Alexandru , Pașcalău Violeta , Toșa Victor , Opruța Dan , Popa Florin , Popa Catalin

Identyfikatory

DOI

10.24425/amm.2022.139705

• Języki publikacji: EN

Abstrakty

EN

This paper presents a comparative study on the effects of the in-situ surface modifications performed on “H” type microfluidic systems obtained via additive manufacturing. The microsystem was printed using a polylactic acid filament on an Ender-5 Pro printer. The surface modification of the main channel was done using chloroform by two different methods: vapor smoothing and flushing. The obtained surface roughness was studied using an optical microscope and the ImageJ software, as well as scanning electron microscopy. The effect of the channel surface treatment upon the characteristics of the fluid flow was assessed. The microfluidic systems were used for the dynamic study of biofilm growth of Candida albicans (ATCC 10231). The influence of the surface roughness of the main channel on the formation and growth of the biofilm was studied using quantitative methods, scanning electron microscopy imaging as well as optical coherence tomography.

Słowa kluczowe

EN

additive manufacturing; microfluidic systems; surface roughness; biofilm growth; laminar flow

• Wydawca: Institute of Metallurgy and Materials Science of Polish Academy of Sciences ; Committee of Materials Engineering and Metallurgy of Polish Academy of Sciences
• Czasopismo: Archives of Metallurgy and Materials
• Rocznik: 2022
• Tom: Vol. 67, iss. 3
• Strony: 1071--1078
• Opis fizyczny: Bibliogr. 29 poz., fot., rys., tab., wzory

Twórcy

autor

Csapai Alexandra

• Materials Science and Engineering Department, Technical University of Cluj-Napoca, 103-105 Muncii Ave., 400641 Cluj-Napoca, Romania

• https://orcid.org/0000-0002-5876-3313

autor

Țoc Dan-Alexandru

• Iuliu Hatieganu University of Medicine and Pharmacy, 8 Victor Babeș Street, 400000 Cluj-Napoca, Romania

• https://orcid.org/0000-0003-3930-5920

autor

Pașcalău Violeta

• Materials Science and Engineering Department, Technical University of Cluj-Napoca, 103-105 Muncii Ave., 400641 Cluj-Napoca, Romania

• https://orcid.org/0000-0002-4119-6906

autor

Toșa Victor

• Materials Science and Engineering Department, Technical University of Cluj-Napoca, 103-105 Muncii Ave., 400641 Cluj-Napoca, Romania

• https://orcid.org/0000-0002-7879-4563

autor

Opruța Dan

• Thermal Engineering Department, Technical University of Cluj-Napoca, 103-105 Muncii Ave., 400641 Cluj-Napoca, Romania

• https://orcid.org/0000-0002-8906-3301

autor

Popa Florin

• Materials Science and Engineering Department, Technical University of Cluj-Napoca, 103-105 Muncii Ave., 400641 Cluj-Napoca, Romania

• https://orcid.org/0000-0002-8849-1902

autor

Popa Catalin

• Materials Science and Engineering Department, Technical University of Cluj-Napoca, 103-105 Muncii Ave., 400641 Cluj-Napoca, Romania

• https://orcid.org/0000-0003-4188-1169

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Uwagi

1. This work was supported by the grants of the Romanian Ministry of Research and Innovation, CCCDI-UEFISCDI, Project number PN-III-P1-1.2-PCCDI-2017-0221/59 PCCDI/2018 (IMPROVE), within PNCDI III and Project number PN-III-P1-1.2-PCCDI-2017-0010/74PCCDI/2018, within PNCDI III.

2. Opracowanie rekordu ze środków MNiSW, umowa nr SONP/SP/546092/2022 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2024).